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Duopa is the brand name for carbidopa/levodopa and is available as enteral suspension.

Duopa is an enteral suspension that contains 4.63 mg of carbidopa and 20 mg of levodopa per mL.

Duopa is a combination medication that treats symptoms of advanced Parkinson’s disease (PD), particularly movement problems.

Duopa is a combination medication used to increase dopamine levels in the brain. Levodopa is a dopamine replacement. Once you take levodopa, it travels into the brain where it turns into dopamine. Carbidopa is a dopa decarboxylase inhibitor. It stops dopa decarboxylase, a protein in the body that breaks down levodopa before levodopa can reach the brain. By blocking this protein, more levodopa can get to the brain and turn into dopamine. This increases levodopa’s ability to relieve PD symptoms.

Duopa is given using a pump that sends the medication into your intestine through a PEG-J tube. The infusion pump is set up for your specific treatment plan.

In general, there are three parts to each Duopa infusion:

• A morning dose that’s given over 10 to 30 minutes
• A continuous dose that’s infused over 16 hours
• Extra doses as needed (no more than every 2 hours)

Duopa is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:

• Currently take or have taken nonselective monoamine oxidase inhibitors (MAOIs) in the past 2 weeks

Common side effects of Duopa:

• Issues related to tube placement
• Nausea
• Constipation
• Redness around the area where the tube is placed
• Involuntary movements
• Depression
• Discharge after the procedure where the tube is placed
• Swelling in the legs or feet
• High blood pressure
• Upper respiratory tract infection
• Mouth or throat pain
• Collapsed lung

Serious side effects are rare with . Contact your healthcare provider immediately if you experience any of the following:

• Serious stomach problems related to the procedure for tube placement: stomach pain; constipation for more than a few days; nausea; vomiting; fever; blood in your stool; dark, tarry stool
• Withdrawal symptoms after stopping suddenly: confusion, very high fevers, sweating, muscle stiffness, irregular pulse, changes in blood pressure
• Heart problems: chest pain that might travel to the arm, neck, or jaw; shortness of breath; cold sweat
• Suicidal thoughts or behavior

The following medications may interact with Duopa:

• Antihypertensives
• Tricyclic antidepressants
• Anticholinergics
• Dopamine receptor antagonists Benzodiazepines
• Isoniazide
• Phenytoin
• Papaverine
• Sympathicomimetics
• Iron
• Protein-rich diet
• COMT inhibitors

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It is not known whether this medication is safe for you and your unborn baby during pregnancy. Talk to your doctor if you are already pregnant or if you have plans on becoming pregnant. They will recommend what is best for you.

• Carbidopa/Levodopa