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MEDICAL INFORMATION

Vydura Key Facts

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About Vydura

Vydura contains the active ingredient rimegepant and is used to relieve migraine attacks. Vydura can also be taken for the prevention of migraines in people who get regular migraines. The active ingredient rimegepant blocks the function of CGRP (calcitonin gene-related peptide), a neuropeptide which plays a role in triggering migraines.

You can take Vydura either when you feel a migraine starting, to relieve your symptoms, or if you suffer with migraines often, you can take Vydura every other day to prevent them. 

NowPatient offers Vydura as a treatment for migraines following an online consultation with a prescriber.

Key facts of Vydura

  • For the treatment of migraine with or without aura or as a preventative treatment if you have more than four migraines a month
  • The most common side effect when taking Vydura is nausea
  • Vydura can interact with strong CYP3A4 inhibitors (clarithromycin, itraconazole, ritonavir). If you’re not sure if it is safe to use with other treatments, discuss this with the prescribing clinician

Who is Vydura suitable for?

Vydura is suitable for adults over the age of 18 who have a history of migraines with or without aura. It may be appropriate for you to take Vydura every other day as a preventative treatment if you have more than four migraines a month.

Who is Vydura not suitable for?

Vydura may not be suitable for some people. To make sure it’s safe for you, speak to the NowPatient prescribing clinician before using Vydura if you:

  • Are pregnant or breastfeeding 
  • Have a severe liver or kidney condition 
  • Are allergic to any of the ingredients 

How and where to get Vydura?

You can buy Vydura safely and securely from NowPatient. You can start a consultation today for free and if you qualify for treatment, you only pay for the cost of the medication. Delivery is made to your home or office from our registered pharmacy.

Our service is certified, safe and effective, and we only ever treat conditions. If you book a consultation with a prescribing clinician for the treatment of migraines, you can discuss if Vydura is a suitable treatment option for you.

At the end of the consultation, the clinician will decide if a treatment plan is suitable for you. If it is, the clinician will issue you with a prescription which can then be ordered, paid for and delivered directly to your chosen address by NowPatient.

Dosage and strength of Vydura for migraines

The recommended dose of Vydura for acute treatment of migraine is 75 mg as needed, once daily. The recommended dose of Vydura for the prevention of migraine is 75 mg every other day. The maximum dose of Vydura per day is 75 mg.

What happens if you use too much Vydura?

Using more than the prescribed amount of Vydura will not improve your condition. However, no overdose symptoms have been reported. If you have taken too much Vydura speak to your doctor or reach out to one of our prescribing clinicians.

What are the side effects of Vydura?

Side effects of Vydura are split into common and serious.

Common side effects include:

  • Nausea

Serious side effects include:

  • Hypersensitivity, including dyspnoea and severe rash

If you experience any serious side effects, you should contact NHS 111.

If you experience a serious allergic reaction with the signs shown below, you should contact emergency services on 999:

  • Your lips, mouth, throat or tongue suddenly become swollen
  • You’re breathing very fast or struggling to breathe (you may become very wheezy or feel like you’re choking or gasping for air)
  • Your throat feels tight or you’re struggling to swallow
  • Your skin, tongue or lips turn blue, grey or pale (if you have black or brown skin, this may be easier to see on the palms of your hands or soles of your feet)
  • You suddenly become very confused, drowsy or dizzy
  • Someone faints and cannot be woken up

Always report adverse effects to the MHRA Yellow Card reporting system. You can read more about this here: How and where do I report side effects of my medication?

Information about using Vydura with other medications 

Using Vydura alongside other treatments such as clarithromycin, itraconazole and ritonavir should be avoided. Let your prescribing clinician know if you are using any of these other medications.

Why might Vydura not work for migraines?

Vydura may not work for several reasons, such as drug interactions, incorrect dosage or timings, loss of effectiveness or individual variations in response to treatment. If your symptoms have not improved, you should speak with your healthcare provider for further advice.

Can Vydura be used long term?

Vydura does not cause medication overuse headaches, unlike other migraine treatments. Long-term use should however always be monitored by a healthcare professional.

How to store Vydura

  • Keep Vydura out of the sight and reach of children
  • Do not use this medicine after the expiry date shown on the carton. (marked as “EXP”). The expiry date refers to the last day of that month
  • Do not store above 30 °C and store in the original package in order to protect from moisture
  • Do not dispose of unused Vydura cream in wastewater or household waste. Ask your pharmacist how to properly dispose of medicines you no longer use. These steps help protect the environment

Is there a herbal Vydura?

No. Herbal Vydura does not exist. If you have been marketed such a product, it may be counterfeit or unsafe.

Should I avoid any particular food or drink when using Vydura?

You can eat and drink normally while using Vydura, but be aware, you don’t need to take it with food or drink.

What lifestyle changes can I make to help with migraine?

Getting regular sleep and meals, staying hydrated, exercise and managing stress can all help to manage migraines. Identify triggers such as alcohol and caffeine to avoid them.

Alternatives to Vydura

Alternatives for the treatment of migraine include Relpax, Imigran, Maxalt and Zomig. Your prescriber will help decide which option is most suitable for you.

Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

FAQs

Answers to Popular Questions About Vydura

What is Vydura?

Vydura is a brand name for rimegepant, a CGRP (calcitonin gene-related peptide) receptor antagonist (gepant) available as 75 mg orodispersible tablets. Vydura is licensed in the UK for both the acute treatment and prevention of migraine in adults. It represents a new class of migraine therapy that targets the CGRP pathway — a key driver of migraine attacks — without causing vasoconstriction, making it suitable for patients with cardiovascular risk factors who cannot take triptans.

How does Vydura work?

Vydura blocks the CGRP receptor. During a migraine, CGRP is released from trigeminal sensory nerve endings, causing vasodilation, neurogenic inflammation, and pain signal transmission. By blocking CGRP from binding to its receptor, Vydura interrupts this cascade, relieving migraine headache and associated symptoms. Unlike triptans, Vydura does not cause vasoconstriction, making it a safer option for patients with ischaemic heart disease, peripheral vascular disease, or uncontrolled hypertension.

Can Vydura be used for both treating and preventing migraines?

Yes, Vydura is unique in being licensed for both acute treatment and prophylaxis. For acute treatment: 75 mg as a single dose at migraine onset (maximum 75 mg in 24 hours). For prevention: 75 mg every other day. This dual indication makes Vydura a versatile option for patients with episodic migraine, potentially replacing the need for separate acute and preventive medications.

How do I take Vydura?

For acute migraine: place one 75 mg orodispersible tablet on the tongue and allow it to dissolve — no water is needed. Take at the onset of migraine. Maximum one dose per 24 hours. For prevention: take one 75 mg tablet every other day. The orodispersible formulation is convenient when nausea makes swallowing tablets difficult during a migraine attack. Vydura can be taken with or without food.

What are the side effects of Vydura?

Common side effects include nausea and hypersensitivity reactions. Vydura is generally well-tolerated with a side effect profile close to placebo in clinical trials. Unlike triptans, Vydura does not cause triptan sensations (chest tightness, tingling). The most significant potential risk is hypersensitivity reactions, including severe cases — discontinue if a serious reaction occurs. Vydura has no risk of medication-overuse headache at the standard dosing schedule.

Who should not take Vydura?

Vydura should not be used in patients with severe hepatic impairment or end-stage renal disease. It is contraindicated with strong CYP3A4 inhibitors. Caution is advised in moderate hepatic or renal impairment. Vydura should not be used during pregnancy. It is an important option for patients who cannot take triptans due to cardiovascular contraindications.

How can I get Vydura?

Vydura requires a prescription from your GP, neurologist, or online prescriber such as NowPatient. NICE has recommended Vydura for acute migraine treatment. NHS availability may depend on local formulary decisions. Your prescriber will assess your migraine pattern, previous treatments, and suitability for Vydura.

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We are a broad skilled and passionate group of clinicians with experience of operating in health systems in the United Kingdom & United States. Providing excellent care and advice is at the heart of everything we do. You can read more about our medical team by visiting the medical team page or learn more about how we curate content by visiting our editorial process