Zoely
Book a quick face-to-face video consultation with a certified prescribing pharmacist, nurse, or doctor. If approved, your Zoely will be prescribed* and delivered straight to your door with free next-day delivery†. No hidden fees. No delays. Just expert care.
* Includes Free Private Prescription & Consultation.
† Applies to UK only.


Other Related Treatments
MEDICAL INFORMATION
Zoely Key Facts
Other Related Names or Treatments
Microgynon 30 ED, Levest, Rigevidon
About Zoely
Zoely is a combined hormonal contraceptive used to provide protection against pregnancy. It contains nomegestrol acetate, a progesterone and estradiol, an oestrogen as its active ingredients.
Zoely works by stopping the release of an egg each month from the ovaries, preventing ovulation during the menstrual cycle. It also makes cervical mucus thicker, making it more difficult for sperm to pass through the cervix, and makes the lining of the womb thinner, so fertilised eggs are less likely to implant in the uterus wall.
NowPatient offers the Zoely birth control pills for the prevention of pregnancy only, following an online consultation with a prescribing clinician.
Key facts of Zoely
- For the prevention of pregnancy
- There is no evidence that the Zoely pill causes weight gain
- Zoely has some common side effects which include headache and migraine
- It can be dangerous if you take Zoely with certain medications. If you’re not sure if it is safe, discuss this with the prescribing clinician
- Zoely will not prevent the transmission of sexually transmitted infections (STIs)
Who is Zoely not suitable for?
Zoely may not be suitable for some people. To make sure it’s safe for you, speak to the prescribing clinician before taking Zoely if you:
- Are allergic to the active ingredients nomegestrol acetate or estradiol, or inactive ingredients such as lactose
- Have ever had a blood clot in the leg or lungs
- Have a family history of heart attacks or stroke
- Have ever had angina or transient ischaemic attack
- Suffer from migraines with aura
- Have a liver disease, liver tumours or any other liver problems
- Have kidney failure
- Have ever had breast cancer or cancer of the cervix, vagina or uterus
- Have unexplained vaginal bleeding
- Have suffered from jaundice, pemphigoid gestationis (a rash involving blisters of the hands and feet), or pruritus while pregnant
- Have a family history of breast cancer
- Have pancreatitis (inflammation of the pancreas)
- Have diabetes
- Have Crohn’s disease or ulcerative colitis
- Have haemolytic uraemic syndrome, high blood cholesterol, or sickle cell anaemia
- Have epilepsy
- Have systemic lupus erythematosus
How and where to get Zoely?
You can buy Zoely safely and securely from NowPatient. You can start a consultation today for free and if you qualify for treatment, you only pay for the cost of the medication. Delivery is made to your home or office from our registered pharmacy.
Our service is certified, safe and effective, and we only ever treat conditions. If you book a consultation with a prescribing clinician for a contraceptive, you can discuss if Zoely is a suitable treatment option for you.
At the end of the consultation, the clinician will decide if a treatment plan is suitable for you. If it is, the clinician will issue you with a prescription which can then be ordered, paid for and delivered directly to your chosen address by NowPatient.
Dosage and strength for Zoely for contraception
The Zoely blister pack contains 28 tablets. 24 white tablets with active substances (2.5 mg nomegestrol acetate and 1.5 mg estradiol) and 4 yellow tablets with inactive substances.
Information about how to take Zoely for contraception
You should start Zoely tablets with an active tablet on the first day of your menstrual cycle. Take your tablets in order of the day of the week and follow the directions printed on the pack. You should expect withdrawal bleeding during the 4 days you take the yellow inactive tablets. Start your next blister pack after the last yellow inactive tablet even if your period has not finished.
Read the patient information leaflet provided with your medication or speak to a healthcare professional if you need further information.
What happens if you take too much Zoely?
If you take more than prescribed, then it can lead to some unpleasant side effects. You should talk to your doctor or reach out to one of our prescribing clinicians, if you have taken too much Zoely and you experience any of the following side effects.
What are the side effects of Zoely?
Side effects of Zoely are split into common and serious.
Common side effects include:
- Breast tenderness
- Breast pain
- Weight changes
- Breakthrough bleeding between periods
- Mood changes
- Headache and migraine
- Nausea, vomiting or diarrhoea
- Vaginal dryness
- Vaginal thrush
- High blood pressure
- Hair loss
Serious side effects include:
- Increased risk of blood clots
- Cervical cancer
If you experience any serious side effects, you should contact NHS 111.
If you experience a serious allergic reaction with the signs shown below you should contact emergency services on 999.
- Your lips, mouth, throat or tongue suddenly become swollen
- You’re breathing very fast or struggling to breathe (you may become very wheezy or feel like you’re choking or gasping for air)
- Your throat feels tight or you’re struggling to swallow
- Your skin, tongue or lips turn blue, grey or pale (if you have black or brown skin, this may be easier to see on the palms of your hands or soles of your feet)
- You suddenly become very confused, drowsy or dizzy
- Someone faints and cannot be woken up
Always report adverse effects to the MHRA yellow card reporting system. You can read more about this here How and where do I report side effects of my medication? – NowPatient
Information about taking Zoely at the same time as other medications or herbal supplements
There is not enough evidence to suggest there are any drug interactions between herbal supplements and Zoely. In any event, you should let your prescribing clinician know if you are taking any herbal supplements or other medications such as:
- Epilepsy treatments – phenytoin or carbamazepine
- Rifampicin
- HIV medicines – ritonavir
- Hepatitis C medicines – telaprevir or boceprevir
- Antifungal medicines – ketoconazole or griseofulvin
- St John’s Wort
- Medicines for high blood pressure, chest pain or irregular heartbeats – diltiazem or verapamil
Why might Zoely not work for contraception?
Zoely may not work for you and common reasons may be:
- Missed pills
- Taking other medicines that interfere with Zoely
- Zoely not being absorbed due to vomiting and diarrhoea
Can Zoely taken for contraception be taken long term?
Using medication like Zoely is safe, provided your doctor has approved it. You should speak to your doctor when deciding to stay on hormonal contraception long term.
Is there a herbal Zoely?
No. Herbal Zoely does not exist. If you have been marketed such a formulation, it may be fake.
Can women use Zoely?
Women can take Zoely for contraception, but it is not advised when breast-feeding. Speak to your doctor if you are considering taking Zoely while you are breast-feeding.
Should I avoid any particular food or drink when taking Zoely?
You can eat and drink normally when taking Zoely
Alternatives to Zoely
Alternative methods of contraception include:
- Implants
- Intrauterine devices (IUDs)
- Oral birth control pills (combined oral contraceptive pill and progestogen only pill)
- Vaginal rings
- Barrier method – condoms, diaphragms
- Tubal ligation and vasectomy
- Emergency contraception
Sources
Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
Related Articles
FAQs
Answers to Popular Questions About Zoely
What is Zoely?
Zoely is a combined oral contraceptive pill containing nomegestrol acetate 2.5 mg and estradiol 1.5 mg. It is unique among UK combined pills because it uses natural oestrogen (estradiol) rather than synthetic ethinylestradiol. Zoely is a monophasic 24/4 regimen — 24 active tablets followed by 4 placebo tablets, with no pill-free break. It is manufactured by Theramex.
How does Zoely work?
Zoely suppresses ovulation through the combined action of nomegestrol acetate and estradiol. The use of natural estradiol rather than synthetic ethinylestradiol may have a more favourable metabolic profile. Nomegestrol acetate is a potent progestogen derived from progesterone with anti-androgenic properties. The 24/4 regimen provides 24 days of active pills and 4 inactive pills, reducing the hormone-free interval.
What makes Zoely different from other pills?
Zoely is distinctive for using natural estradiol, which may offer metabolic advantages over ethinylestradiol. It may be suitable for women who experience oestrogen-related side effects on pills containing ethinylestradiol. Withdrawal bleeds on Zoely are typically shorter and lighter. Some women experience no withdrawal bleed, which is not harmful. VTE data specific to this combination are limited, but the natural oestrogen may theoretically carry a lower VTE risk.
How do I take Zoely?
Take one Zoely tablet daily at approximately the same time for 21 consecutive days. Then have a 7-day pill-free break during which a withdrawal bleed usually occurs. Start the next pack after the 7-day break whether or not bleeding has finished. If starting on day 1 of your period, you have immediate contraceptive protection. If starting at any other time, use condoms for the first 7 days. Swallow the tablet whole with water.
What should I do if I miss a Zoely pill?
Follow the standard FSRH missed pill guidance for combined pills. One pill missed (less than 48 hours late): take it as soon as you remember and continue as normal — no additional contraception needed. Two or more pills missed (more than 48 hours late): take the last missed pill, leave any earlier missed ones, use condoms for 7 days, and follow week-specific guidance. Week 1: consider emergency contraception if unprotected sex occurred. Week 3: skip the pill-free break and start the next pack immediately.
What are the common side effects of Zoely?
Common side effects of Zoely include headache, nausea, breast tenderness, mood changes, breakthrough bleeding or spotting (especially in the first 2–3 months), changes in libido, and weight changes. These usually settle as the body adjusts. If side effects persist beyond 3 months or are significantly affecting your quality of life, speak to your prescriber about trying a different pill formulation.
Who should not take Zoely?
Zoely has the same contraindications as all combined oral contraceptive pills. It should not be taken by women with a history of VTE, arterial thrombosis, stroke, or heart attack; uncontrolled hypertension; migraine with aura; smokers aged over 35; breast cancer; severe liver disease; or certain inherited clotting disorders. Your prescriber will assess your eligibility using UKMEC criteria (UK Medical Eligibility Criteria for Contraceptive Use).
Can I take Zoely during pregnancy or breastfeeding?
No, Zoely should not be taken if you are pregnant. If you suspect pregnancy, stop the pill and take a pregnancy test. Combined pills are not recommended during breastfeeding in the first 6 weeks after birth, and are generally avoided until 6 months postpartum if fully breastfeeding, as oestrogen may reduce milk supply. Progestogen-only options are preferred while breastfeeding. After stopping the pill, fertility usually returns within 1–3 months.
How can I get Zoely?
Zoely is available on NHS prescription from your GP, contraception clinic, or through online services like NowPatient. Your prescriber will check your blood pressure, BMI, and medical history before prescribing. NowPatient offers convenient online contraceptive consultations with qualified UK prescribers and home delivery.
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