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Valproate Sodium is available as a 250 mg oral capsule and a 250 mg/5 ml oral solution.

Valproate Sodium is an antiepileptic and is used to treat focal impaired awareness seizure and
absence seizures.

Valproate Sodium is an antiepileptic. The exact way it works to control seizures isn’t well understood. But it’s thought that Valproate Sodium signals your brain to make more of a chemical called gamma-aminobutyric acid (GABA). GABA helps to lower the bursts of activity in your brain, which can help to prevent seizure episodes.

Valproate Sodium is typically taken by mouth and your dose will be determined based on your weight. The typical starting dose ranges from 10 mg/kg to 15 mg/kg by mouth per day. Your physician will raise your dose weekly as needed to better control the seizures. The maximum daily dose is 60 mg/kg.

Valproate Sodium is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not take this medication if you have hepatic disease or significant hepatic dysfunction, a known hypersensitivity to the drug, or have urea cycle disorders.

Common side effects of Valproate Sodium include:

• Tremor
• Nausea
• Headache
• Excess sleepiness
• Vomiting
• Feeling weak
• Dizziness
• Hair loss
• Diarrhea
• Stomach pain

Serious side effects are rare with Valproate Sodium. Contact your healthcare provider immediately if you experience any of the following.

• Allergic reaction: trouble breathing or swallowing, swelling (on your face, lips, mouth, or throat), peeling skin, rash, hives.

The following medications may interact with Valproate Sodium:

• Hepatic enzyme-inducing drugs (e.g., phenytoin, carbamazepine, phenobarbital, primidone, rifampin) can increase Valproate Sodium clearance
• while enzyme inhibitors (e.g., felbamate) can decrease Valproate Sodium clearance
• Aspirin, carbapenem antibiotics – Monitoring of Valproate Sodium concentrations is recommended
• Co-administration of Valproate Sodium can affect the pharmacokinetics of other drugs (e.g. diazepam, ethosuximide, lamotrigine, phenytoin) by
• inhibiting their metabolism or protein binding displacement. Dosage adjustment of amitryptyline/nortryptyline, warfarin, and zidovudine may be necessary if used concomitantly with Valproate Sodium
• Topiramate – Hyperammonemia and encephalopathy

Various FDA-approved generic manufacturers

Valproate Sodium can cause congenital malformations including neural tube defects and decreased IQ. Only use Valproate Sodium to treat pregnant women with epilepsy if other medications are unacceptable.

• Depakene