Valproate sodium

Valproate sodiumPrices, Coupons & Savings

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*Based on the difference between the U&C price submitted and the price the patient paid, as of April 2023.

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  2. Valproate Sodium
    Generic for Depakene
    30 milliliterss $3.9 USD
    Save $-0.30
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Do you need a prescription for valproate sodium?

Yes, valproate sodium is only available with a valid physician Rx.

How much is valproate sodium without Insurance in the US?

Our website gives two competitive savings options to US customers who wish to purchase valproate sodium, as either a brand or generic, if available. The first is access to medications through our mail-order online pharmacy. The second is by using the Now Patient Rx Advantage Card, which can be used in over 65,000 pharmacies nationwide, across America. If you are insured, then in most cases, the cash price will be significantly cheaper than the copay.

What will my out-of-pocket cost be for valproate sodium in the US?

There are no out-of-pocket (OOP) costs because we are currently only offering a cash-based option to purchase medications.

Is Now Patient a valproate sodium savings card?

Yes. Save up to 90% on your valproate sodium with the FREE Now Patient Rx Advantage card*.
*Based on the difference between the U&C submitted by the pharmacy and the price the patients pay.

Can you handle Rx transfers for home delivery in the US?

Yes. If you use the mail-order online pharmacy option, then we can handle requests by you to have your prescription transferred to our pharmacy for home delivery. We can even help you manage your refills by giving you timely reminders, so you do not run out of your medication.

Is Now Patient a valproate sodium coupon provider in the US?

No. Now Patient does not provide valproate sodium coupons or FREE valproate sodium samples.

Do you accept commercial, Medicare or Medicaid coverage for valproate sodium in the US?

No. Currently, we only offer cash-based options for purchase, therefore we do not require your insurance benefit details. In the future, our plan is to be able to handle commercial insurance, Medicare and Medicaid including cases where you have multiple health plans that provide benefit coverage (e.g. Medicaid and Commercial). We also anticipate being able to handle more complex scenarios such as using primary insurance combined with a manufacturer copay assistance program.

Does Now Patient work with Medicare?

Our cash-based prices for medications are typically cheaper than Medicare copays. We do not bill Medicare Part D (standalone drug coverage) or Medicare Advantage (combined health and drug coverage). When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

Does Now Patient work with Commercial Insurance?

Our cash-based prices for medications are typically cheaper than commercial plan copays. We do not bill your commercial plan. When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

What should you do if you use too much valproate sodium?


Call your doctor right away or seek immediate medical attention if your symptoms do not improve or they become worse after using valproate sodium. You can also call 800-222-1222 to reach the American Association of Poison Control Centers or use its online resource if you think you’ve used too much valproate sodium. But if you have severe symptoms, call 911 (or your local emergency number) immediately or go to the nearest emergency room.


If you think it is an emergency, call 999 or find your nearest A&E
If you need help now, but it’s not an emergency go to 111.nhs.uk or call 111. Alternatively you can speak to one of our pharmacists or use the Now Patient app to make an appointment with your GP.

What should I do if I miss my dose?

There are occasions when people forget to take their medication at correct prescribed times. This may not only have an effect on potentially making the medication less effective but it may also inadvertently lead to taking doses too close together, thereby increasing the risks of side effects.

Click here to find out what to do if you forgot to take your medication

What is generic valproate sodium?

Generic valproate sodium refers to the non-brand-name version of the medication. It contains the same active ingredient as the brand-name drug but is typically less expensive.

FDA approval of valproate sodium

Valproate sodium is approved by the U.S. Food and Drug Administration (FDA) for the treatment of certain types of seizures, including absence seizures, complex partial seizures, and acute manic or mixed episodes associated with bipolar disorder.

Active ingredient of valproate sodium

The active ingredient of valproate sodium is sodium valproate.

US brand name of valproate sodium and manufacturer

Valproate sodium is available in the US under various brand names, including Depakote, Depakene, and Stavzor. The manufacturers may vary depending on the brand names.

UK brand name of valproate sodium and manufacturer

In the UK, valproate sodium is available under various brand names, including Epilim and Depakote. The manufacturer may vary depending on the brand name.

Prescription requirement for valproate sodium

A prescription (Rx) is required for valproate sodium in both the US and the UK.

Availability of valproate sodium in the UK with NHS prescription

Valproate sodium is available in the UK with an NHS prescription.

Conditions treated by valproate sodium

Valproate sodium is an anticonvulsant/antiepileptic drug used for the treatment of epilepsy (types of seizures), as monotherapy and adjunctive therapy for absence seizures and complex partial seizures. It may also be used in patients who have acute manic or mixed episodes associated with bipolar disorder. Occasionally it may be used to prevent migraine headaches.

How does valproate sodium work?

The exact mechanism of action of valproate sodium in the treatment of seizures and bipolar disorder is not fully understood. It is believed to work by increasing the levels of gamma-aminobutyric acid (GABA), a neurotransmitter that inhibits the excessive activity in the brain.

Forms of valproate sodium available

Valproate sodium is available in various formulations, including oral tablets, capsules, and oral solution.

Dosage of valproate sodium

The dosage of valproate sodium may vary depending on the specific condition being treated, the severity of the condition, and other individual factors. It is important to follow the recommended dosage instructions provided by the healthcare professional.

Directions for valproate sodium use

Valproate sodium should be taken as directed by the healthcare provider. The specific instructions may include the timing of administration, dosage adjustments, and any necessary precautions.

Warnings and contraindications for valproate sodium

  • Valproate sodium may cause serious side effects, including hepatotoxicity, pancreatitis, birth defects (oral clefts, spina bifida, cardiovascular and limb malformations), hyperammonemia, encephalopathy, and CNS depression (which may impair your ability to perform physical or mental tasks)
  • Regular monitoring of liver function and blood cell counts may be required during treatment with valproate sodium
  • Tell your doctor if you have a certain medical conditions such as Alpers Huttenlocher Syndrome, urea cycle disorder, or liver disease
  • Valproate sodium is not recommended for use in pregnant women as it may cause fetal harm. Women of a childbearing age should speak to their doctor before starting treatment
  • Valproate sodium passes into breast milk. Speak to your doctor if you are breastfeeding

Possible side effects of valproate sodium

Common side effects of valproate sodium may include weight gain, nausea, vomiting, dizziness, drowsiness, and tremor. If these side effects persist or worsen, it is important to contact a healthcare provider. Get medical help right away if you have a life threatening allergic reaction. Symptoms include hives, trouble breathing, worsening shortness of breath, sore throat, chest pain, swelling of the face, tongue or throat, skin rash, blisters, and serious skin reactions.

Interactions with other drugs

Valproate sodium may interact with other medications, including anticoagulants such as warfarin, clonazepam, ethosuximide, felbamate, certain hormonal contraceptives, phenobarbital, phenytoin, sedatives, topiramate, and zidovudine. It is important to inform your healthcare provider about all the prescription drugs, over the counter nonprescription medications, salt substitutes, herbal products, supplements, and vitamins you are taking to avoid potential adverse effects and drug interactions.

Similar drugs to valproate sodium

Divalproex sodium and valproic acid are similar medications to valproate sodium. They are all used by the body as valproic acid. Other antiepileptic medications, such as carbamazepine, lamotrigine, phenytoin, and topiramate, may be used as alternatives to valproate sodium for the treatment of seizures. For bipolar disorder, other mood stabilizers, such as lithium and lamotrigine, may be prescribed.


Stefano Mirabello Medical Reviewer
Pharmacist / B.Pharm
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