Used for Migraines and Epilepsy

View DEPAKENE savings options available to you including Manufacturer Coupons, Rx Advantage Savings Card, Canadian Prescription Savings or DEPAKENE Patient Assistance Program.

Programs are suitable for individuals who want to buy DEPAKENE without insurance, with insurance or for those who are underinsured. You can pay as little as $0 per fill.*

Manufactured by AbbVie, Inc.

*Applicable to Drug Coupons & Patient Assistance Programs

This content is intended for US audiences only

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    Save up to 90%

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Jamie Winn NowPatientGreen tick
Updated on 26 Apr 2024

Learn more about DEPAKENE



DEPAKENE is the brand name for valproic acid and is available as an oral capsule and solution.

What dosages is DEPAKENE available in?

What dosages is DEPAKENE available in?

DEPAKENE is available as a 250 mg oral capsule and a 250 mg/5 ml oral solution.

What is DEPAKENE used for?

What is DEPAKENE used for?

DEPAKENE is an antiepileptic and is used to treat focal impaired awareness seizure and
absence seizures.

How does DEPAKENE work?

How does DEPAKENE work?

DEPAKENE is an antiepileptic. The exact way it works to control seizures isn’t well understood. But it’s thought that DEPAKENE signals your brain to make more of a chemical called gamma-aminobutyric acid (GABA). GABA helps to lower the bursts of activity in your brain, which can help to prevent seizure episodes.

How do I take DEPAKENE?

How do I take DEPAKENE?

DEPAKENE is typically taken by mouth and your dose will be determined based on your weight. The typical starting dose ranges from 10 mg/kg to 15 mg/kg by mouth per day. Your physician will raise your dose weekly as needed to better control the seizures. The maximum daily dose is 60 mg/kg.

Is it safe for me to take DEPAKENE?

Is it safe for me to take DEPAKENE?

DEPAKENE is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not take this medication if you have hepatic disease or significant hepatic dysfunction, a known hypersensitivity to the drug, or have urea cycle disorders.

DEPAKENE Common Side Effects

DEPAKENE Common Side Effects

Common side effects of DEPAKENE include:

  • Tremor
  • Nausea
  • Headache
  • Excess sleepiness
  • Vomiting
  • Feeling weak
  • Dizziness
  • Hair loss
  • Diarrhea
  • Stomach pain
DEPAKENE Serious Side Effects

DEPAKENE Serious Side Effects

Serious side effects are rare with DEPAKENE. Contact your healthcare provider immediately if you experience any of the following.

  • Allergic reaction: trouble breathing or swallowing, swelling (on your face, lips, mouth, or throat), peeling skin, rash, hives.
Effects of other drugs, drug classes and over-the-counter products on DEPAKENE

Effects of other drugs, drug classes and over-the-counter products on DEPAKENE

The following medications may interact with DEPAKENE:

  • Hepatic enzyme-inducing drugs (e.g., phenytoin, carbamazepine, phenobarbital, primidone, rifampin) can increase DEPAKENE clearance
  • while enzyme inhibitors (e.g., felbamate) can decrease DEPAKENE clearance
  • Aspirin, carbapenem antibiotics – Monitoring of DEPAKENE concentrations is recommended
  • Co-administration of DEPAKENE can affect the pharmacokinetics of other drugs (e.g. diazepam, ethosuximide, lamotrigine, phenytoin) by
  • inhibiting their metabolism or protein binding displacement. Dosage adjustment of amitryptyline/nortryptyline, warfarin, and zidovudine may be necessary if used concomitantly with DEPAKENE
  • Topiramate – Hyperammonemia and encephalopathy
Who makes DEPAKENE?

Who makes DEPAKENE?

AbbVie, Inc.

Is DEPAKENE safe in pregnancy?

Is DEPAKENE safe in pregnancy?

DEPAKENE can cause congenital malformations including neural tube defects and decreased IQ. Only use DEPAKENE to treat pregnant women with epilepsy if other medications are unacceptable.


What to do if you missed your DEPAKENE dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

Learn more about reporting side effects
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Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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