siponimod
Used for Multiple Sclerosis
NowPatient helps you obtain your siponimod prescription for free or at low-cost. Drug savings programs are suitable for individuals who are insured, don't have insurance or are underinsured and can't afford your medicine.
Manufactured by various FDA-approved generic manufacturers.
*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.
This content is intended for US audiences only
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siponimod key facts
What dosages is siponimod available in?
siponimod is available as a 0.25 mg, 1 mg, and 2 mg oral tablet.
What is siponimod used for?
siponimod is a sphingosine 1-phosphate receptor modulator and is used to treat relapsing forms of multiple sclerosis (MS).
How does siponimod work?
siponimod is a sphingosine 1-phosphate (S1P) receptor modulator. It attaches to the S1P receptor protein found on your white blood cells. This blocks white blood cells from leaving your lymph nodes and releasing into the body. The exact way siponimod works to treat MS is unknown. But it’s thought to lower the number of white blood cells that reaches your nervous system where they can cause nerve damage.
How do I take siponimod?
Your dose of siponimod will depend on your genetic makeup, which can affect how well your body can break down the medication. For this reason, you’ll need to do genetic testing before starting siponimod (siponimod) so your provider can choose the appropriate dose for you. In general, the typical starting dose is 0.25 mg by mouth once daily. Then, your provider will slowly raise your dose over 4 or 5 days to reach the target maintenance dose of 1 mg or 2 mg once daily.
Is it safe for me to take siponimod?
siponimod is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:
- Patients with a CYP2C9*3/*3 genotype
- In the last 6 months, experienced myocardial infarction, unstable angina, stroke, TIA, decompensated heart failure requiring hospitalization, or Class
III/IV heart failure - Presence of Mobitz type II second-degree, third-degree AV block, or sick sinus syndrome, unless patient has a functioning pacemaker
siponimod Common Side Effects
Common side effects of siponimod:
- Headache
- High blood pressure
- Higher liver enzyme levels in the blood
- Falls
- Swelling of the arms and legs
- Nausea
- Dizziness
- Diarrhea
- Low heart rate
- Pain in arms or legs
siponimod Serious Side Effects
Serious side effects are rare with siponimod. Contact your healthcare provider immediately if you experience any of the following.
- Infection: fever, difficulty breathing, diarrhea, weakness, cough, stomach pain, sweating, chills
- Dangerously slow heart rate: dizziness, tiredness, weakness, confusion, feeling faint, trouble breathing, chest pain
- Liver problems: nausea, vomiting, stomach pain, swelling of your stomach, yellowing of your skin or the whites of your eyes, clay-colored stool
- Skin cancer: skin changes, swollen lymph nodes
- Brain problems: severe headaches, visual changes, difficulty staying awake, weakness on one side of the body, dizziness, trouble speaking, seizure
Effects of other drugs, drug classes and over-the-counter products on siponimod
The following medications may interact with siponimod:
- Vaccination: Avoid live-attenuated vaccines during and for up to 4 weeks after treatment with siponimod
- CYP2C9 and CYP3A4 Inhibitors: Increase in siponimod exposure; concomitant use of siponimod with moderate CYP2C9 and moderate or strong CYP3A4 inhibitors is not recommended.
- CYP2C9 and CYP3A4 Inducers: Decrease in siponimod exposure; concomitant use of siponimod with moderate CYP2C9 and strong
- CYP3A4 inducers is not recommended
Who makes siponimod?
Various FDA-approved generic manufacturers
Is siponimod safe in pregnancy?
siponimod may harm your unborn baby. Talk to your healthcare provider right away if you become pregnant while taking siponimod or if you become pregnant within 10 days after you stop taking siponimod. If you are a woman who can become pregnant, you should use effective birth control during your treatment with siponimod and for at least 10 days after you stop taking siponimod. There is a registry for women who become pregnant during treatment with siponimod. If you become pregnant while taking siponimod, talk to your healthcare provider about registering with the MotherToBaby Pregnancy Study in Multiple Sclerosis. The purpose of this registry is to collect information about your health and your baby’s health. For more information or to register, contact MotherToBaby by calling 1-877-311-8972, by sending an email to MotherToBaby@health.ucsd.edu, or go to Mother to baby
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effects in the USDrug Savings Guide
A practical guide to saving money and receiving support with prescription costs
How can NowPatient help me to lower the cost of my siponimod prescription?
After you create a FREE account with NowPatient, you will have access to 4 programs that can help lower the cost of your siponimod prescription
Applicability to each program will be dependent on your insurance status.
How do the NowPatient siponimod savings programs work?
After you have created your FREE account with NowPatient, you can access the various programs from your account dashboard. Each program has clear instructions on how to check your eligibility. You can see how the process works by clicking on the feature link below and seeing the ‘How it works’ steps.
Drug Coupon and Patient Assistance Programs require an eligibility quiz to be completed.
Are the NowPatient siponimod savings programs suitable for everyone, regardless of insurance status?
No. Each program has its own eligibility and applicability requirements. The table below shows if a program is available to you, based on your insurance status.
| Rx Advantage Card* for siponimod | Canadian Prescription Savings* for siponimod | siponimod Drug Coupon* | siponimod Patient Assistance Program* | |
| Insured (federal, state or government) | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured (Commercial or Private) | Available | Available | Available If Offered by Pharmaceutical Company | Available If Offered by Pharmaceutical Company |
| Uninsured | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured but without pharmacy benefit or drug coverage | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
*This is not insurance.
Are the NowPatient drug savings programs suitable for brand and generic versions of siponimod?
No. Each program has applicability requirements. Please see below
| Rx Advantage Card* for siponimod | Canadian Prescription Savings* for siponimod | siponimod Drug Coupon* | siponimod Patient Assistance Program* | |
| Brand | Yes | Yes | Yes, If Offered by Pharmaceutical Company | Yes, If Offered by Pharmaceutical Company |
| Generic | Yes | Yes | No | No |
*This is not insurance.
If you have Medicare Part D or Medicare Advantage and none of the siponimod savings options are applicable or affordable for me, what can you do?
If you are insured with Medicare and the siponimod drug savings options are not applicable to you and still remain unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and after you have selected your state, it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
People who qualify for both Medicare and Medicaid are called ‘dual eligibles’.
If you are denied Medicaid for siponimod, and you are still unable to afford your copay or co-insurance element (for example if you are in the coverage gap or Donut Hole) then you may be eligible for a federal support program like Low Income Subsidy. To be eligible for Low Income Subsidy, you need to be a resident in one of the 50 States or the District of Columbia. You can check eligibility online at SSA Medicare D Extra Help. You can also call Social Security at 1-800-772-1213 (TTY 1-800-325-0778).
I am uninsured or underinsured and none of the siponimod prescription saving options are applicable or affordable for me, what can I do?
If you are uninsured or underinsured (for example, siponimod is not covered by your plan) and the drug savings options are not applicable or still unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
If you are denied and all else fails, and if you have been prescribed siponimod for an FDA-approved indication, you can call the pharmaceutical company to see if they have any other assistance programs.
I am commercially or privately insured and none of the siponimod prescription saving options are applicable or affordable for me, what can I do?
If your medication is not covered by your plan, you can appeal your insurance company’s decision. Sometimes, a formal appeal can result in the drug being covered if it is deemed medically necessary.
If you cannot afford your copay contribution, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
However, being privately insured might complicate your eligibility for Medicaid, as having private insurance may be considered in the financial eligibility assessment.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. If you qualify, state Medicaid may cover the full cost of your medication.
If I have federal, state or commercial insurance and none of the siponimod prescription saving options are applicable or affordable for me, are there any other support organisations that can help me with my co-insurance or copay contributions?
If you have already tried Medicaid and received a denial letter or if you are insured with Medicare and have been denied Low-Income Subsidy, then you can try one of the following organizational support programs:
1. Patient Access Network Foundation (PAN) assistance for siponimod
If you are having trouble paying for your siponimod medication due to unaffordable copays or deductibles, the Patient Access Network Foundation (PAN), may be able to assist you. To qualify for PAN assistance for siponimod you will need to meet one or all of the following criteria:
- Your income is below 400% of the federal poverty level
- siponimod is prescribed for an approved FDA indication
- You live in and receive treatment in the United States or U.S. territories, even if you do not have U.S. citizenship
- You have Medicare insurance coverage that covers siponimod
- If siponimod is listed on PAN’s list of covered medications
You can check the Patient Access Network Foundation Website for more information.
2. HealthWell Foundation Copay Program for siponimod
If you are having trouble paying for your siponimod medication due to unaffordable copays or deductibles, the HealthWell Foundation Copay Program may be able to assist you. To qualify for assistance for siponimod you will need to meet the following criteria:
- You live in and are being treated in the United States
- You are insured and your plan covers siponimod
- If siponimod is listed on the HealthWell Foundation’s list of covered medications
You can check the HealthWell Foundation Website for more information.
3. Patient Advocate Foundation Co-Pay Relief Program for siponimod
Patient Advocate Foundation’s Co-Pay Relief program exists to help reduce the financial distress you or your family may face when paying for your siponimod treatment. If you qualify and can demonstrate the need, the foundation will provide you with direct payment covering co-pays, co-insurance, and deductibles. To qualify for assistance for siponimod you will need to meet the following criteria:
- You must be currently insured and have coverage for siponimod
- You must have a confirmed diagnosis and treatment plan
- You must reside and receive treatment in the United States
- Your Income must fall at or below 300% or 400% of the Federal Poverty Guideline (FPG) with consideration for the Cost of Living Index (COLI) and number in the household
- Applications can also be completed by contacting the program sponsor, toll-free at 866-512-3861.
You can check the Patient Advocate Foundation Website for more information.
Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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