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Glyburide is a sulfonylurea and is used to treat type 2 diabetes.

Glyburide is in a class of medications known as sulfonylureas. Sulfonylureas work by telling your pancreas to release insulin, which lowers your blood sugar.

Glyburide is typically dosed as 2.5 mg to 5 mg by mouth once daily with breakfast or the first main meal. Your provider will work with you to adjust your dose weekly until your blood sugar level is the target range. The typical maintenance dose ranges from 1.25 mg to 20 mg by mouth, either once daily or divided into smaller doses and taken twice daily.

Glyburide is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have a hypersensitivity to the drug or type 1 diabetes mellitus, diabetic ketoacidosis, with or without coma or are taking bosentan.

Common side effects of Glyburide include:

• Feeling bloated
• Nausea
• Heartburn

Serious side effects are rare with Glyburide. Contact your healthcare provider immediately if you experience any of the following.

• Severe low blood sugar: anxiety, sweating, shaking, confusion, dizziness, weakness, fast heartbeat, feeling hungry, seizures

• The hypoglycemic action of sulfonylureas may be potentiated by certain drugs including nonsteroidal anti-inflammatory agents, ACE inhibitors, disopyramide, fluoxetine, clarithromycin, and other drugs that are highly protein bound, salicylates, sulfonamides, chloramphenicol, probenecid, monoamine oxidase inhibitors, and beta adrenergic blocking agents
• A possible interaction between Glyburide and fluoroquinolone antibiotics has been reported resulting in a potentiation of the hypoglycemic action of Glyburide
• Rifampin may worsen glucose control of Glyburide because rifampin can significantly induce metabolic isozymes of Glyburide such as CYP2C9 and 3A4

Various FDA-approved generic manufacturers

Various FDA-approved generic manufacturers

Glyburide hasn’t been well-studied in human pregnancy, so it’s not known whether this medication will cause harm to unborn babies. But there have been reports of babies experiencing seriously low blood sugar levels during delivery. If you’re pregnant or thinking about becoming pregnant, talk with your provider about what medication options are best for you.