GlyburidePrices, Coupons & Savings

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*Based on the difference between the U&C price submitted and the price the patient paid, as of April 2023.

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  2. Glyburide
    Generic for Glyburide
    30 tablets $3.6 USD
    Save $8.10
  3. Glyburide
    Generic for Glyburide
    30 tablets $3.9 USD
    Save $7.80
  4. Glyburide
    Generic for Glyburide
    30 tablets $3.6 USD
    Save $8.10
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Do you need a prescription for glyburide?

Yes, glyburide is only available with a valid physician Rx.

How much is glyburide without Insurance in the US?

Our website gives two competitive savings options to US customers who wish to purchase glyburide, as either a brand or generic, if available. The first is access to medications through our mail-order online pharmacy. The second is by using the Now Patient Rx Advantage Card, which can be used in over 65,000 pharmacies nationwide, across America. If you are insured, then in most cases, the cash price will be significantly cheaper than the copay.

What will my out-of-pocket cost be for glyburide in the US?

There are no out-of-pocket (OOP) costs because we are currently only offering a cash-based option to purchase medications.

Is Now Patient a glyburide savings card?

Yes. Save up to 90% on your glyburide with the FREE Now Patient Rx Advantage card*.
*Based on the difference between the U&C submitted by the pharmacy and the price the patients pay.

Can you handle Rx transfers for home delivery in the US?

Yes. If you use the mail-order online pharmacy option, then we can handle requests by you to have your prescription transferred to our pharmacy for home delivery. We can even help you manage your refills by giving you timely reminders, so you do not run out of your medication.

Is Now Patient a glyburide coupon provider in the US?

No. Now Patient does not provide glyburide coupons or FREE glyburide samples.

Do you accept commercial, Medicare or Medicaid coverage for glyburide in the US?

No. Currently, we only offer cash-based options for purchase, therefore we do not require your insurance benefit details. In the future, our plan is to be able to handle commercial insurance, Medicare and Medicaid including cases where you have multiple health plans that provide benefit coverage (e.g. Medicaid and Commercial). We also anticipate being able to handle more complex scenarios such as using primary insurance combined with a manufacturer copay assistance program.

Does Now Patient work with Medicare?

Our cash-based prices for medications are typically cheaper than Medicare copays. We do not bill Medicare Part D (standalone drug coverage) or Medicare Advantage (combined health and drug coverage). When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

Does Now Patient work with Commercial Insurance?

Our cash-based prices for medications are typically cheaper than commercial plan copays. We do not bill your commercial plan. When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

What should you do if you use too much glyburide?


Call your doctor right away or seek immediate medical attention if your symptoms do not improve or they become worse after using glyburide. You can also call 800-222-1222 to reach the American Association of Poison Control Centers or use its online resource if you think you’ve used too much glyburide. But if you have severe symptoms, call 911 (or your local emergency number) immediately or go to the nearest emergency room.


If you think it is an emergency, call 999 or find your nearest A&E
If you need help now, but it’s not an emergency go to 111.nhs.uk or call 111. Alternatively you can speak to one of our pharmacists or use the Now Patient app to make an appointment with your GP.

What should I do if I miss my dose?

There are occasions when people forget to take their medication at correct prescribed times. This may not only have an effect on potentially making the medication less effective but it may also inadvertently lead to taking doses too close together, thereby increasing the risks of side effects.

Click here to find out what to do if you forgot to take your medication

What is glyburide?

Glyburide is an oral medication used for the management of type 2 diabetes mellitus. It belongs to the class of drugs called sulfonylureas, which work by stimulating the release of insulin from the pancreas and increasing the body’s sensitivity to insulin. It is important to note that glyburide is typically prescribed alongside a proper diet and exercise regimen to effectively manage type 2 diabetes. It is not used to treat type 1 diabetes or diabetic ketoacidosis.

FDA approval of glyburide

Glyburide is approved by the U.S. Food and Drug Administration (FDA) for the treatment of type 2 diabetes.

Active ingredient of glyburide

The active ingredient of glyburide is glyburide.

US brand name of glyburide and manufacturer

Glyburide is available in the United States under various brand names, including Diabeta, Micronase, and Glynase. It is manufactured by different pharmaceutical companies, including Pfizer, Inc.

UK brand name of glyburide and manufacturer

In the United Kingdom, glyburide is called glibenclamide

Generic availability of glyburide

Generic versions of glyburide are available and are typically sold under the name glyburide.

Prescription requirement for glyburide

Glyburide is a prescription medication in the United States and the United Kingdom. It is important to consult a healthcare provider to determine if glyburide is appropriate for you and to receive the correct dosage instructions.

Availability of glyburide in the UK with NHS prescription

Glyburide is available as glibenclamide with a National Health Service (NHS) prescription in the United Kingdom. It can be obtained from pharmacies with a valid prescription from a healthcare professional.

Conditions treated by glyburide

Glyburide is primarily used for the management of type 2 diabetes mellitus, particularly when diet and exercise alone are not sufficient to control blood sugar levels.

How does glyburide work?

Glyburide works by stimulating the release of insulin from the beta cells in the pancreas and increasing the body’s sensitivity to insulin. This helps to lower blood glucose levels and improve glycemic control in individuals with type 2 diabetes.

Forms of glyburide available

Glyburide is available as an oral tablet.

Dosage of glyburide

The dosage of glyburide may vary depending on individual factors, such as the severity of diabetes, response to treatment, and other medications being taken. It is important to follow the dosage instructions provided by the healthcare provider and not exceed the prescribed dose. If you happen to miss a dose of glyburide, it is important to take the missed dose as soon as you remember. However, if it is already close to the time for your next scheduled dose, it is best to skip the missed dose and continue with your regular dosing schedule. Do not double up on doses to make up for the missed one.

Directions for glyburide use

Glyburide is typically taken orally with breakfast or the first main meal of the day. It is important to take glyburide exactly as prescribed by the healthcare provider and follow their instructions regarding the dosing schedule and any specific precautions. Store at room temperature away from light and moisture.

Side effects of glyburide

Some common side effects of glyburide include:

  • Glyburide works by stimulating the release of insulin from the pancreas, which can sometimes cause blood sugar levels to drop too low. Symptoms of severe hypoglycemia (low blood sugar) include dizziness, sweating, blurred vision, confusion, and shakiness
  • Some individuals taking glyburide may experience weight gain as a side effect. This can be attributed to the medication’s ability to increase insulin production, which can lead to increased appetite and subsequent weight gain
  • Glyburide can sometimes cause digestive problems such as nausea, vomiting, heartburn, diarrhea, or stomach pain. These side effects are generally mild and resolve on their own
  • In rare cases, glyburide can cause allergic reactions such as rash, itching, or swelling of the face, lips, or throat. If any of these symptoms occur, immediate medical attention should be sought
  • Some individuals may experience increased sensitivity to sunlight while taking glyburide. This can result in sunburn more easily or skin rashes when exposed to sunlight. Use sunscreen and wear protective clothing when outdoors
  • Although rare, glyburide has been associated with liver disease/problems such as jaundice or hepatitis. If any signs of liver dysfunction, such as yellowing of the skin or eyes, abdominal pain, or dark urine, occur, medical attention should be sought immediately

Warnings and precautions

  • People who have an enzyme deficiency known as glucose-6-phosphate dehydrogenase (G6PD) deficiency may develop hemolytic anemia with glyburide. Be sure to talk with your doctor if you have this enzyme deficiency
  • Glyburide is contraindicated in people with type 1 diabetes or with diabetic ketoacidosis (DKA)
  • If you have reduced kidney function or kidney disease, discuss with your doctor how this medication may affect your medical condition

Drug interactions 

When considering taking glyburide with other medications, it is crucial to consider any potential drug interactions that may occur. For example, certain medications can increase or decrease the blood sugar-lowering effects of glyburide, leading to either hyperglycemia (high blood sugar) or hypoglycemia (low blood sugar). Here are some types of drugs that should not be taken with glyburide:

  • NSAIDs like ibuprofen, naproxen, or aspirin can increase the risk of hypoglycemia (low blood sugar) when taken with glyburide. These medications can also impair the blood-sugar-lowering effects of glyburide, reducing its effectiveness
  • Beta-blockers such as atenolol, propranolol, or metoprolol, which are used to treat high blood pressure or heart conditions, may mask the symptoms of hypoglycemia. This can make it difficult to recognize and treat low blood sugar levels when taking glyburide
  • Medications like hydrochlorothiazide or chlorthalidone, commonly used to treat high blood pressure, can raise blood sugar levels. When combined with glyburide, the risk of hyperglycemia (high blood sugar) may increase
  • Monoamine oxidase (MAO) inhibitors, such as phenelzine or tranylcypromine are used to treat depression. Taking them with glyburide can increase the risk of hypoglycemia and may also prolong the effects of glyburide, leading to a higher risk of low blood sugar levels

It is important to always consult with your healthcare provider before starting any new medications, including over-the-counter drugs, herbal supplements, or vitamins while taking glyburide. They can provide you with the necessary information and guidance to ensure your safety and manage any potential adverse effects.

Is glyburide safe to take if I am pregnant or planning on becoming pregnant?

Glyburide is not recommended for use during pregnancy. It is important to discuss with your healthcare provider the use of glyburide if you are pregnant or planning to become pregnant. Alternative treatment options may be considered.

Is glyburide safe to take If I am breastfeeding?

It is not recommended to take glyburide while breastfeeding. It is important to consult with a healthcare provider for individualized recommendations.


Stefano Mirabello Medical Reviewer
Pharmacist / B.Pharm
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