ethinyl estradiol/cyproterone acetate
Used for Acne
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Manufactured by various FDA-approved generic manufacturers.
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ethinyl estradiol/cyproterone acetate Uses, Side Effects, Interactions, Warnings & Dosing
What dosages is ethinyl estradiol/cyproterone acetate available in?
ethinyl estradiol/cyproterone acetate is available as an oral tablet that contains ethinylestradiol 0.035 mg and cyproterone acetate 2 mg. It also comes with 7 placebo tablets.
What is ethinyl estradiol/cyproterone acetate used for?
ethinyl estradiol/cyproterone acetate is an antiandrogen and an estrogen that is used for:
Moderate to severe acne related to androgen-sensitivity (with or without seborrhoea) and/or hirsutism in women of reproductive age. The prevention of pregnancy.
How does ethinyl estradiol/cyproterone acetate work?
ethinyl estradiol/cyproterone acetate is an antiandrogen and estrogen combination. These medicines work by blocking the effects of a class of hormones called androgens. Cyproterone also supresses ovulation and therefore has a contraceptive effect.
How do I take ethinyl estradiol/cyproterone acetate?
ethinyl estradiol/cyproterone acetate comes as a pre-packaged course (28 days) of medication. There are 21 active tablets and 7 placebo tablets and they don’t contain any active medication. The typical dose is to take 1 active tablet by mouth daily for 21 days, followed by 1 placebo tablet daily for the remaining 7 days. The tablets must be taken in order as shown on the medication packaging.
Is it safe for me to take ethinyl estradiol/cyproterone acetate?
ethinyl estradiol/cyproterone acetate is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following.
- Hypersensitivity to the active substances or to any of the excipients.
- Venous thrombosis present or in history (deep venous thrombosis, pulmonary embolism).
- Arterial thrombosis present or in history (e.g. myocardial infarction) or prodromal conditions (e.g.
angina pectoris and transient ischaemic attack). - Presence or history of cerebrovascular accident
- History of migraine with focal neurological symptoms
- The presence of a severe or multiple risk factor(s) for venous or arterial thrombosis such as, diabetes mellitus with vascular symptoms, severe hypertension, or severe dyslipoproteinaemia
- Hereditary or acquired predisposition for venous or arterial thrombosis, such as activated protein C (APC) resistance, antithrombin-III-deficiency, protein C deficiency, protein S deficiency, hyperhomocysteinaemia and antiphospholipid-antibodies (anticardiolipin-antibodies, lupus anticoagulant)
- Severe hepatic disease as long as liver function values have not returned to normal
- Use of direct-acting antiviral (DAA) medicinal products containing ombitasvir, paritaprevir, or dasabuvir, and combinations of these.
- Presence or history of liver tumours (benign or malignant)
- Known or suspected sex-steroid influenced malignancies (e.g. of the genital organs or the breasts)
Undiagnosed vaginal bleeding - Concomitant use with another hormonal contraceptive.
Known or suspected pregnancy - Lactation
ethinyl estradiol/cyproterone acetate Common Side Effects
Common side effects of ethinyl estradiol/cyproterone acetate:
- Nausea
- Abdominal pain
- Increased weight
- Headache
- Depression or mood changes
- Brest pain
- Breast tenderness
ethinyl estradiol/cyproterone acetate Serious Side Effects
Serious side effects are rare with ethinyl estradiol/cyproterone acetate. Contact your healthcare provider immediately if you experience any of the following.
- Heart attack: chest pain, stomach discomfort, sweating, nausea, dizziness
- Stroke: sudden numbness or weakness in the arm, leg, or face, confusion, trouble seeing, headache, difficulty walking
- Deep vein thrombosis (blood clot in the leg): leg cramp, swelling, pain, muscle tightness
- Pulmonary embolism (blood clot in the lung): cough, chest pain, trouble breathing, racing heart
- Liver problems: yellowing of the skin or the whites of the eyes, tiredness, stomach pain
Effects of other drugs, drug classes and over-the-counter products on ethinyl estradiol/cyproterone acetate
The following medications may interact with ethinyl estradiol/cyproterone acetate:
- Substances increasing the clearance of ethinyl estradiol/cyproterone acetate (diminished efficacy by enzyme-induction), e.g.: Phenytoin, barbiturates, primidone, carbamazepine, rifampicin, and possibly also oxcarbazepine topiramate, felbamate, griseofulvin, and products containing St. John’s wort
- Substances with variable effects on the clearance of ethinyl estradiol/cyproterone acetate, e.g.: When co-administered with combined oral contraceptives, many HIV/HCV protease inhibitors and nonnucleoside reverse transcriptase inhibitors can increase or decrease plasma concentrations of estrogen or progestin. These changes may be clinically relevant in some cases
- Substances decreasing the clearance of ethinyl estradiol/cyproterone acetate (enzyme inhibitors)
- Strong and moderate CYP3A4 inhibitors such as azole antifungals (e.g. itraconazole, voriconazole fluconazole), verapamil, macrolides (e.g. clarithromycin, erythromycin), diltiazem and grapefruit juice can increase plasma concentrations of the estrogen or the progestin or both
Who makes ethinyl estradiol/cyproterone acetate?
Various FDA-approved generic manufacturers
Is ethinyl estradiol/cyproterone acetate safe in pregnancy?
ethinyl estradiol/cyproterone acetate should not be used during pregnancy. Inform your doctor immediately if you become pregnant while taking ethinyl estradiol/cyproterone acetate.
What is the brand name for ethinyl estradiol/cyproterone acetate?
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Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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