Used for Epilepsy

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Manufactured by various FDA-approved generic manufacturers.

*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.

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Updated on 24 Apr 2024

phenytoin Uses, Side Effects, Interactions, Warnings & Dosing

What dosages is phenytoin available in?

What dosages is phenytoin available in?

phenytoin is available as a 100 mg, 200 mg, and 300 mg extended-release oral capsule, a 50 mg chewable tablet, and a 125 mg/5 ml oral suspension.

What is phenytoin used for?

What is phenytoin used for?

phenytoin is an antiepileptic and is used to treat tonic-clonic (grand mal) seizures, psychomotor (temporal lobe) seizures, and seizures during and following brain surgery.

How does phenytoin work?

How does phenytoin work?

phenytoin is an antiepileptic medication. It prevents seizures by decreasing abnormal signals between nerve cells in the brain.

How do I take phenytoin?

How do I take phenytoin?

phenytoin is typically taken by mouth with a starting dose of 1 capsule (100 mg) by mouth 3 times a day, slowly increasing up to a maximum of 2 capsules (200 mg) by mouth 3 times a day. Your physician will adjust the dose based on blood levels of this medication.

Is it safe for me to take phenytoin?

Is it safe for me to take phenytoin?

phenytoin is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have a known hypersensitivity to phenytoin, its ingredients, or other hydantoins, a history of prior acute hepatotoxicity attributable to phenytoin, or are currently taking delavirdine.

phenytoin Common Side Effects

phenytoin Common Side Effects

Common side effects of phenytoin include:

  • Uncontrolled eye movements
  • Abnormal/worsening coordination
  • Slurred speech
  • Sleepiness
  • Mental confusion
phenytoin Serious Side Effects

phenytoin Serious Side Effects

Serious side effects are rare with phenytoin. Contact your healthcare provider immediately if you experience any of the following.

  • Status epilepticus (seizures lasting longer than 5 minutes or when seizures occur so closely together that the person doesnt’t recover between seizures) due to missed doses or sudden stopping of phenytoin
  • Serious allergic reactions: skin reactions, swelling, trouble breathing
  • Serious liver injury: darkened urine, nausea, vomiting, stomach pain, yellowing of your skin or eyes, itching
  • Suicidal thoughts or behavior
Effects of other drugs, drug classes and over-the-counter products on phenytoin

Effects of other drugs, drug classes and over-the-counter products on phenytoin

The following medications may interact with phenytoin:

  • Multiple drug interactions because of extensive plasma protein binding, saturable metabolism and potent induction of hepatic enzymes. Interactions can occure with stomach acid reducers, sedatives, antidepressants, estrogen hormone replacement, phenothiazines, disulfiram, methylphenidate, sulfa drugs, carbamazepine, sucralfate, molindone, phenobarbital, valproic acid, divalproex sodium, steroids, antibiotics, digoxin, furosemide, or theophylline
Who makes phenytoin?

Who makes phenytoin?

Various FDA-approved generic manufacturers

Is phenytoin safe in pregnancy?

Is phenytoin safe in pregnancy?

phenytoin may cause fetal harm when administered to a pregnant woman. There is a pregnancy exposure registry that monitors pregnancy outcomes in women exposed phenytoin during pregnancy. You can call the tollfree number 1-888-233-2334. Information on the registry can also be found at the AED pregnancy registry


What to do if you missed your phenytoin dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

Learn more about reporting side effects
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Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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