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Is the cost of your deferasirox too expensive?

You may qualify for programs where you can pay as little as $0 per fill, subject to income and insurance status.

This content is intended for US audiences only

NowPatient offers cost effective access to deferasirox for everyone including those who are uninsured, those who have commercial insurance as well as those who are enrolled into state or federal programs like Medicaid, Medicare Part D, full Low Income Subsidy (LIS, “Extra Help”), TRICARE or Veterans (VA) Benefits.

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Table of contents
OverviewWhat can I do if I am commercially insured but cannot afford my deferasirox?What can I do if I am uninsured and cannot afford my deferasirox?What can I do if I am insured with Medicare and cannot afford my deferasirox?Am I eligible for the Rx Advantage Card and how much does deferasirox cost without insurance?What will my out-of-pocket cost be for deferasirox when using the Rx Advantage Card?Is it legal for me to pay cash for deferasirox even though I have insurance?Does the Rx Advantage Card work with Medicare or any other federal or state insurance plans?Does the Rx Advantage Card work with Commercial Insurance?How do I check prices for deferasirox and how do I use the Rx Advantage Card?Do I need to pay for the Rx Advantage Card?Is there a deferasirox co-pay program?Is there a deferasirox Patient Assistance Program (PAP)?What should I do if I take too much deferasirox?What are the benefits of NowPatient?US brand name of deferasirox and manufacturerUK brand name of deferasirox and manufacturerAvailability of deferasiroxFDA approval of deferasiroxNHS prescription (UK) for deferasiroxMechanism of actionUses of deferasiroxDosage of deferasirox and directionsIs it safe to take deferasirox if I am pregnant or planning on becoming pregnant?Is it safe to take deferasirox while breastfeeding?Drug interactionsSide effects of deferasiroxSourcesPeople also asked
Navin Khosla NowPatientGreen tick
Medically reviewed by Navin Khosla, BPharm and written by Rajive Patel, BPharm - Updated on 25 Jan 2024
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What can I do if I am commercially insured but cannot afford my deferasirox?

If you are commercially insured and you cannot afford your copay or co-insurance you can opt for purchasing deferasirox outside of your plan using the Rx Advantage card, with costs that are usually lower than a typical plan copay. If you elect to use this method, out of pocket costs do not contribute towards your plan deductibles.

If you cannot afford the cash price possibly due to income constraints, then there is the option of applying to state assistance programs like Medicaid. Often, you may be able to receive your deferasirox without any costs at all. You can check Medicaid eligibility in your state by following this link HealthCare.gov. The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application.

What can I do if I am uninsured and cannot afford my deferasirox?

If you cannot afford the cash price of deferasirox using the Rx Advantage card then there is the option of applying to state programs like Medicaid. Often, you may be able to receive your deferasirox without any costs at all. You can check Medicaid eligibility in your state by following this link HealthCare.gov. The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application.

What can I do if I am insured with Medicare and cannot afford my deferasirox?

If you are insured with Medicare and have Part D or an Advantage drug plan but cannot afford your copay or co-insurance element (for example if you are in the coverage gap or Donut Hole) then you have a number of options:

Option

Savings Information

RX ADVANTAGE CARD

You can use the Rx Advantage to purchase the medication outside of your plan at prices that may be lower than you copay or co-insurance element. If you elect to use this method, out of pocket costs do not contribute towards your plan deductibles.

LOW INCOME SUBSIDY

If this is still too expensive or unaffordable then you can apply for federal support like Low Income Subsidy (LIS). To be eligible for Low Income Subsidy, you need to be resident in one of the 50 States or the District of Columbia. You can check eligibility online at SSA Medicare D Extra Help. You can also call Social Security at 1-800-772-1213 (TTY 1-800-325-0778).

MEDICAID

Alternatively, you can check Medicaid eligibility in your state by following this link to the HealthCare.gov. The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.

Am I eligible for the Rx Advantage Card and how much does deferasirox cost without insurance?

Our website gives savings options to customers who wish to purchase deferasirox, as either a brand or generic, without the constraints of insurance. By using the Rx Advantage Card, users can save up to 90% on the cost of their medication. The card can be used at over 65,000 pharmacies nationwide, across America. Even if you are insured, in most cases the cash price will be significantly cheaper than your existing co-pay. NowPatient is able to negotiate discounts on bulk drug purchases with pharmacy owners meaning you can access lower medication prices at nearby pharmacies using our card that can be conveniently stored in your NowPatient account.

What will my out-of-pocket cost be for deferasirox when using the Rx Advantage Card?

Your out-of-pocket (OOP) cost will effectively be the discounted cash price you pay for deferasirox using the Rx Advantage Card. If you are insured, your OOP expense can not be used against your plan deductible, if your plan has a deductible.

Yes. The Rx Advantage card is especially useful for people who have High-deductible health plans (HDHPs). It can be used for insured, uninsured, and underinsured persons.

Does the Rx Advantage Card work with Medicare or any other federal or state insurance plans?

No. We do not bill any federal or state insurance including Medicare Part D (standalone drug coverage) or Medicare Advantage (combined health and drug benefit). When you purchase your medication using the NowPatient Rx Advantage Card, you will be doing so out of pocket. The spend will not count towards your plan deductibles or gaps in the event you have a plan with a deductible. The out-of-pocket deferasirox cash price you pay can be typically cheaper than your plan copay.

Does the Rx Advantage Card work with Commercial Insurance?

We do not bill your commercial insurance. When you purchase your medication using the Rx Advantage Card, from NowPatient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps in the event you have a plan with a deductible. The out-of-pocket deferasirox cash price you pay can be typically cheaper than your plan copay.

How do I check prices for deferasirox and how do I use the Rx Advantage Card?

You can search for the prices at nearby pharmacies using our website. Simply search your medication and enter your ZIP Code and we will show you the price of your drug at nearby pharmacies. If you are happy with the quote, you need to create an account with NowPatient and generate your card. Next, simply go to the pharmacy and fill your deferasirox Rx. Ask the pharmacy to run the card and check the price, even if they tell you they have another card they use. Your card is stored safely in your NowPatient account.

Do I need to pay for the Rx Advantage Card?

No. The Rx Advantage prescription savings card is FREE to use and store for NowPatient users.

Is there a deferasirox co-pay program?

Generic medications like deferasirox do not have co-pay card savings options. A Copay program, if available, would normally be for the brand name version of deferasirox. You can search the brand name of deferasirox and check to see if a co-pay program exists. Co-pay cards are programs run by pharmaceutical companies that offer you a direct way to lower your out-of-pocket costs for prescription drugs for eligible patients. The copay cards essentially allow physicians to prescribe medications that are clinically preferred.

Is there a deferasirox Patient Assistance Program (PAP)?

Generic medications like deferasirox do not have PAP savings options. A Patient assistance program, if available would normally be for the brand name version of deferasirox. You can search the brand name of deferasirox and check to see if a co-PAP exists. PAPs are programs that are run and sponsored by pharmaceutical companies. They offer uninsured, insured, or underinsured individuals access to high-cost brand-name medications, which may otherwise be unaffordable.

What should I do if I take too much deferasirox?

Call your doctor right away or seek immediate medical attention if your symptoms do not improve or they become worse after using deferasirox. You can also call 800-222-1222 to reach the American Association of Poison Control Centers or use its online resource if you think you've used too much deferasirox. But if you have severe symptoms, call 911 (or your local emergency number) immediately or go to the nearest emergency room.

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US brand name of deferasirox and manufacturer

Deferasirox is available under the brand names Jadenu and Exjade, which is manufactured by Novartis Pharmaceuticals Corporation.

UK brand name of deferasirox and manufacturer

In the UK, deferasirox is available under the brand name Exjade, which is manufactured by Novartis Pharmaceuticals.

Availability of deferasirox

Deferasirox is available by prescription only.

FDA approval of deferasirox

Deferasirox has been approved by the U.S. Food and Drug Administration (FDA) for the treatment of chronic iron overload due to blood transfusions in patients aged 2 years and older and for the treatment of chronic iron overload in non-transfusion-dependent thalassemia syndromes in patients aged 10 years and older.

NHS prescription (UK) for deferasirox

Deferasirox may be available in the UK with an NHS prescription. It is important to consult with your healthcare provider or pharmacist to verify availability.

Mechanism of action

Deferasirox is an iron chelator, which means it binds to excess iron in the body and helps to remove it. It works by forming a complex with iron, which is then excreted in the urine or feces. This helps to reduce the iron burden in patients with iron overload conditions.

Uses of deferasirox

Deferasirox is a medication primarily used for the treatment of chronic iron overload in people who receive regular blood transfusions. Here are some of the main uses of deferasirox:

  • Deferasirox is commonly used in the management of thalassemia, a genetic blood disorder that causes abnormal hemoglobin production. People with thalassemia often require frequent blood transfusions, leading to iron buildup in the body. Deferasirox helps to remove excess iron and prevent iron-related complications
  • Individuals with sickle cell disease often receive blood transfusions to manage their condition. As a result, they can also develop iron overload. Deferasirox can be used to reduce iron levels and minimize the risk of iron toxicity
  • Deferasirox is also beneficial for people with other transfusion-dependent anemias, such as myelodysplastic syndromes (MDS), aplastic anemia, and other rare blood disorders. It helps to remove the excess iron accumulated from regular transfusions
  • Although the primary use of deferasirox is for iron overload caused by blood transfusions, it may also be employed in cases where iron accumulation occurs due to other reasons, such as excessive dietary iron absorption or certain genetic conditions

Dosage of deferasirox and directions

The dosage of deferasirox is determined by factors such as the patient’s age, weight, serum ferritin levels, and the presence or absence of transfusion-dependent anemia. It is important to note that the dosage should be individualized and prescribed by a healthcare professional who is experienced in managing iron overload.
For adults and children aged 2 years of age and older with transfusional iron overload, the initial recommended dosage is 20 mg per kilogram of body weight per day. This can be increased up to a maximum of 30 mg per kilogram of body weight per day based on the patient’s response and tolerance.
For non-transfusion-dependent thalassemia patients aged 10 years and older, the recommended starting dosage is 10 mg per kilogram of body weight per day. The dosage can be increased up to a maximum of 20 mg per kilogram of body weight per day.
It is important to follow the dosage instructions provided by the healthcare professional and not exceed the recommended maximum dosage. Regular monitoring of serum ferritin levels and other relevant laboratory tests is necessary to assess the response to treatment and adjust the dosage if needed.
It is worth noting that deferasirox is available in different formulations such as tablets, dispersible tablets, and granules for oral suspension. The healthcare professional will determine the appropriate formulation and dosage based on the patient’s specific needs and preferences.
It is important to take deferasirox exactly as prescribed by your healthcare provider. Do not adjust the dosage or stop taking the medication without consulting your doctor.
It is recommended to take deferasirox on an empty stomach, at least 30 minutes before a meal. However, if you experience gastrointestinal discomfort, it is permissible to take it with a light meal.
Taking deferasirox tablets with food may slightly decrease its absorption into the body. To ensure optimal effectiveness of the medication, it is best to follow the instructions and take it on an empty stomach whenever possible. Administer granules by sprinkling the full dose on soft food (eg, yogurt or apple sauce) immediately before use and administered orally.
Store at room temperature, away from moisture and heat.

Is it safe to take deferasirox if I am pregnant or planning on becoming pregnant?

The safety of deferasirox in pregnancy has not been well established. If you are pregnant, planning to become pregnant or suspect you may be pregnant, it is important to discuss the use of deferasirox with your healthcare provider. They can evaluate the potential risks and benefits to determine the best course of action for your specific situation.

Is it safe to take deferasirox while breastfeeding?

It is not recommended to breastfeed while taking deferasirox. It is important to consult with your healthcare provider for specific guidance on the use of deferasirox while breastfeeding.

Drug interactions

When taking any medication, it is important to be aware of potential drug interactions. Although deferasirox is generally safe to use, it can interact with other drugs, which may affect its effectiveness or cause unwanted side effects. It is crucial to inform your healthcare provider about all the medications, over-the-counter drugs, supplements, and herbal remedies you are taking, as well as any medical conditions you have, before starting treatment with deferasirox.

  • One of the most significant drug interactions associated with iron-chelating agents such as deferasirox is with aluminum-containing antacids. These include common over-the-counter antacids which are used to relieve heartburn or indigestion. When taken together, deferasirox and aluminium-containing antacids can bind to each other in the digestive tract, reducing the absorption of both medications. It is recommended to separate the administration of deferasirox and aluminium-containing antacids by at least two hours to avoid this interaction
  • Certain medications can increase the concentration of deferasirox in the blood, potentially leading to an increased risk of side effects. One such example is drugs that inhibit the enzyme CYP3A4, which is responsible for the breakdown of deferasirox. Examples of medications that can increase deferasirox blood levels include ketoconazole, itraconazole, clarithromycin, and ritonavir. It is important to monitor for signs of toxicity or adverse effects when combining deferasirox with these drugs
  • Deferasirox can cause kidney damage, so combining it with other medications that have similar effects on the kidneys may increase the risk. Examples of such drugs include nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen or naproxen, certain antibiotics such as gentamicin or vancomycin, and certain antifungal medications like amphotericin B
  • You should not use deferasirox if you have severe kidney disease or liver disease, advanced cancer, a blood cell or bone marrow disorder, or low levels of platelets in your blood
  • Deferasirox can also interact with other medications and affect their effectiveness. For example, deferasirox may reduce the effectiveness of hormonal contraceptives, such as birth control pills, patches, or implants. It is recommended to use alternative or additional methods of contraception while taking deferasirox
  • Cholestyramine, a medication used to lower cholesterol levels, may decrease the absorption of deferasirox. It is recommended to separate the administration of cholestyramine and deferasirox by at least 2 hours

Side effects of deferasirox

Common side effects in clinical trials:
Deferasirox may cause some common gastrointestinal side effects, such as nausea, vomiting, and diarrhea. These symptoms are usually mild and improve over time. It is important to stay hydrated and eat small, frequent meals to help manage these side effects.
Serious side effects:
While rare, serious adverse events can occur with deferasirox treatment. These include liver problems, kidney damage, and severe allergic reactions. If you experience symptoms such as yellowing of the skin or eyes, dark urine, loss of appetite, difficulty breathing while taking deferasirox, or vomit that looks like coffee grounds, seek medical attention immediately. Kidney problems like decreased urine output are also possible and should not be ignored. Regular monitoring by your healthcare provider can help identify any potential serious adverse reactions early on.
If you have signs of an allergic reaction (hives, difficulty breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, a red or purple skin rash that spreads and causes blistering and peeling) seek immediate medical attention.
It is important to note that this is not an exhaustive list of side effects. For a complete list, refer to the medication leaflet or consult your healthcare provider.

Sources

Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information in this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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