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Deferasirox is available as a 90 mg, 180 mg, 360 mg oral tablet.

Deferasirox is a chelating agent and is used to treat chronic iron overload (high iron levels in the blood for a long period of time) in people age 2 years and older who receive regular blood transfusions, and people age 10 years and older with a genetic blood condition called non-transfusion-dependent thalassemias (NTDT).

Deferasirox is a chelating agent. It attaches to iron in your blood and allows your body to get rid of the extra iron through stool.

Deferasirox is typically dosed based on your weight and estimated
glomerular filtration rate (eGFR). Your physician will determine your dose.

Deferasirox is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have an estimated GFR less than 40 mL/min/1.73 m2, poor performance status, high-risk myelodysplastic syndrome (MDS), advanced malignancy, platelet count less than 50 x 109/L or a known hypersensitivity to Deferasirox or any component of Deferasirox.

Common side effects of Deferasirox include:

• Diarrhea
• Stomach pain
• Nausea
• Vomiting
• Higher protein levels in urine
• Higher creatinine levels in blood
• Skin rash

Serious side effects are rare with Deferasirox. Contact your healthcare provider immediately if you experience any of the following.

• Sudden kidney injury: feeling sick or weak, dehydration, urinating less than usual, confusion, blood in urine, swelling in the legs, ankles, or feet
• Liver damage: feeling tired or weak, poor appetite, losing weight without trying, dark urine, eyes and skin turning more yellow, upper right stomach pain
• Stomach bleeding: stomach pain, black and tarry stools, blood in the urine
• Low blood cell counts: frequent fevers or infections, bruise or bleed more easily, nose bleeds that don’t stop
  Severe skin reactions: rash, skin pain or peeling, blisters, fever, sore throat, fatigue, facial swelling, swollen lips

The following medications may interact with Deferasirox:

• Do not take Deferasirox with aluminum-containing antacid preparations
• Deferasirox increases the exposure of repaglinide. Consider repaglinide dose reduction and monitor blood glucose levels
• Avoid the use of Deferasirox with theophylline as theophylline levels could be increased
• Deferasirox increases exposure of busulfan. Monitor plasma concentrations of busulfan when coadministered with Deferasirox to allow dose adjustment of busulfan, as needed

Various FDA-approved generic manufacturers

It is not known if Deferasirox can harm your unborn baby. Hormonal forms of birth control may not be as effective if used during treatment with Deferasirox. You could become pregnant. Talk to your healthcare provider about other birth control options that you can use during this time. Tell your healthcare provider right away if you become pregnant during treatment with Deferasirox.

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