Save on Exjade with Coupons, Discounts & Savings Programs

Exjade is the brand name for deferasirox and is available as a tablet for oral suspension.

Exjade is available as a 125 mg, 250 mg, and 500 mg tablet for oral suspension.

Exjade is a chelating agent that is used to treat chronic iron overload (high iron levels in the blood for a long period of time) in:

• People age 2 years and older who receive regular blood transfusions
• People age 10 years and older with a genetic blood condition called non-transfusion-dependent thalassemias (NTDT)

Exjade is a chelating agent. It attaches to iron in your blood and allows your body to get rid of the extra iron through stool.

The dose depends on which form of Exjade you have and your body weight. Your provider will adjust your dose based on how much iron is in your blood.

Chronic iron overload due to blood transfusions:

• Dissolvable tablets (Exjade): The usual starting dose is 20 mg/kg of body weight by mouth once daily on an empty stomach, at least 30 minutes before food. The maximum dose is 40 mg/kg of body weight once daily

Chronic iron overload in NTDT:

Dissolvable tablets (Exjade): The usual starting dose is 10 mg/kg of body weight by mouth once daily on an empty stomach, at least 30 minutes before food. The maximum dose is 20 mg/kg of body weight once daily.

Please note:

• There are different instructions on how to take the tablets, granules, and soluble tablets. Please read the FAQ and Pharmacist tips sections for details

Your dose might differ if you have kidney or liver problems.

Exjade is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:

• Estimated GFR less than 40 mL/min/1.73 m2
• Patients with poor performance status
• Patients with high-risk myelodysplastic syndrome (MDS)
• Patients with advanced malignancies
• Patients with platelet counts less than 50 x 109/L

Common side effects of Exjade:

• Diarrhea
• Stomach pain
• Nausea
• Vomiting
• Higher protein levels in urine
• Higher creatinine levels in blood
• Skin rash

Serious side effects are rare with Exjade. Contact your healthcare provider immediately if you experience any of the following.

• Sudden kidney injury: feeling sick or weak, dehydration, urinating less than usual, confusion, blood in urine, swelling in the legs, ankles, or feet
• Liver damage: feeling tired or weak, poor appetite, losing weight without trying, dark urine, eyes and skin turning more yellow, upper right stomach pain
• Stomach bleeding: stomach pain, black and tarry stools, blood in the urine
• Low blood cell counts: frequent fevers or infections, bruise or bleed more easily, nose bleeds that don’t stop
• Severe skin reactions: rash, skin pain or peeling, blisters, fever, sore throat, fatigue, facial swelling, swollen lips

The following medications may interact with Exjade:

• Do not take Exjade with aluminum-containing antacid preparations
• Exjade increases the exposure of the CYP2C8 substrate repaglinide
• Consider repaglinide dose reduction and monitor blood glucose levels
• Avoid the use of Exjade with CYP1A2 substrate theophylline
• Deferasirox increases exposure of busulfan. Monitor plasma concentrations of busulfan when coadministered with deferasirox to allow dose adjustment of busulfan as needed

Novartis Pharmaceuticals

It is not known if Exjade can harm your unborn baby. Hormonal forms of birth control may not be as effective if used during treatment with Exjade. You could become pregnant. Talk to your healthcare provider about other birth control options that you can use during this time. Tell your healthcare provider right away if you become pregnant during treatment with Exjade.

• Deferasirox