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Jadenu Sprinkle is the brand name for deferasirox and is available as granules.

Jadenu Sprinkle is available as 90 mg, 180 mg, and 360 mg granules.

Jadenu Sprinkle is a chelating agent and is used to treat chronic iron overload (high iron levels in the blood for a long period of time) in people age 2 years and older who receive regular blood transfusions, and people age 10 years and older with a genetic blood condition called non-transfusion-dependent thalassemias (NTDT).

Jadenu Sprinkle is a chelating agent. It attaches to iron in your blood and allows your body to get rid of the extra iron through stool.

Jadenu Sprinkle is dosed as follows:

Chronic iron overload due to blood transfusions:

• Tablets (Jadenu) or granules (Jadenu Sprinkle): The usual starting dose is 14 mg/kg of body weight by mouth once daily on an empty stomach or with a light meal, such as jelly or skim milk. The maximum dose is 28 mg/kg of body weight once daily

Chronic iron overload in NTDT:

• Tablets (Jadenu) or granules (Jadenu Sprinkle): The usual starting dose is 7 mg/kg of body weight by mouth once daily on an empty stomach or with a light meal, such as jelly or skim milk. The maximum dose is 14 mg/kg of body weight once daily

JADENU is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have an estimated GFR less than 40 mL/min/1.73 m2, poor performance status, high-risk myelodysplastic syndrome (MDS), advanced malignancy, platelet count less than 50 x 109/L or a known hypersensitivity to deferasirox or any component of JADENU.

Common side effects of JADENU include:

• Diarrhea
• Stomach pain
• Nausea
• Vomiting
• Higher protein levels in urine
• Higher creatinine levels in blood
• Skin rash

Serious side effects are rare with JADENU. Contact your healthcare provider immediately if you experience any of the following.

• Sudden kidney injury: feeling sick or weak, dehydration, urinating less than usual, confusion, blood in urine, swelling in the legs, ankles, or feet
• Liver damage: feeling tired or weak, poor appetite, losing weight without trying, dark urine, eyes and skin turning more yellow, upper right stomach pain
• Stomach bleeding: stomach pain, black and tarry stools, blood in the urine
• Low blood cell counts: frequent fevers or infections, bruise or bleed more easily, nose bleeds that don’t stop
• Severe skin reactions: rash, skin pain or peeling, blisters, fever, sore throat, fatigue, facial swelling, swollen lips

The following medications may interact with JADENU:

• Do not take JADENU with aluminum-containing antacid preparations
• JADENU increases the exposure of repaglinide. Consider repaglinide dose reduction and monitor blood glucose levels
• Avoid the use of JADENU with theophylline as theophylline levels could be increased
• JADENU increases exposure of busulfan. Monitor plasma concentrations of busulfan when coadministered with JADENU to allow dose adjustment of busulfan, as needed

Novartis Pharmaceuticals

It is not known if JADENU can harm your unborn baby. Hormonal forms of birth control may not be as effective if used during treatment with JADENU. You could become pregnant. Talk to your healthcare provider about other birth control options that you can use during this time. Tell your healthcare provider right away if you become pregnant during treatment with JADENU.

• Deferasirox