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Jamie Winn NowPatientGreen tick
Updated on 26 Apr 2024

JADENU SPRINKLE Uses, Side Effects, Interactions, Warnings & Dosing



JADENU SPRINKLE is the brand name for deferasirox and is available as granules.

What dosages is JADENU SPRINKLE available in?

What dosages is JADENU SPRINKLE available in?

JADENU SPRINKLE is available as 90 mg, 180 mg, and 360 mg granules.

What is JADENU SPRINKLE used for?

What is JADENU SPRINKLE used for?

JADENU SPRINKLE is a chelating agent and is used to treat chronic iron overload (high iron levels in the blood for a long period of time) in people age 2 years and older who receive regular blood transfusions, and people age 10 years and older with a genetic blood condition called non-transfusion-dependent thalassemias (NTDT).

How does JADENU SPRINKLE work?

How does JADENU SPRINKLE work?

JADENU SPRINKLE is a chelating agent. It attaches to iron in your blood and allows your body to get rid of the extra iron through stool.



JADENU SPRINKLE is dosed as follows:

Chronic iron overload due to blood transfusions:

  • Tablets (Jadenu) or granules (JADENU SPRINKLE): The usual starting dose is 14 mg/kg of body weight by mouth once daily on an empty stomach or with a light meal, such as jelly or skim milk. The maximum dose is 28 mg/kg of body weight once daily

Chronic iron overload in NTDT:

  • Tablets (Jadenu) or granules (JADENU SPRINKLE): The usual starting dose is 7 mg/kg of body weight by mouth once daily on an empty stomach or with a light meal, such as jelly or skim milk. The maximum dose is 14 mg/kg of body weight once daily
Is it safe for me to take JADENU SPRINKLE?

Is it safe for me to take JADENU SPRINKLE?

JADENU is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have an estimated GFR less than 40 mL/min/1.73 m2, poor performance status, high-risk myelodysplastic syndrome (MDS), advanced malignancy, platelet count less than 50 x 109/L or a known hypersensitivity to deferasirox or any component of JADENU.

JADENU SPRINKLE Common Side Effects

JADENU SPRINKLE Common Side Effects

Common side effects of JADENU include:

  • Diarrhea
  • Stomach pain
  • Nausea
  • Vomiting
  • Higher protein levels in urine
  • Higher creatinine levels in blood
  • Skin rash
JADENU SPRINKLE Serious Side Effects

JADENU SPRINKLE Serious Side Effects

Serious side effects are rare with JADENU. Contact your healthcare provider immediately if you experience any of the following.

  • Sudden kidney injury: feeling sick or weak, dehydration, urinating less than usual, confusion, blood in urine, swelling in the legs, ankles, or feet
  • Liver damage: feeling tired or weak, poor appetite, losing weight without trying, dark urine, eyes and skin turning more yellow, upper right stomach pain
  • Stomach bleeding: stomach pain, black and tarry stools, blood in the urine
  • Low blood cell counts: frequent fevers or infections, bruise or bleed more easily, nose bleeds that don’t stop
  • Severe skin reactions: rash, skin pain or peeling, blisters, fever, sore throat, fatigue, facial swelling, swollen lips
Effects of other drugs, drug classes and over-the-counter products on JADENU SPRINKLE

Effects of other drugs, drug classes and over-the-counter products on JADENU SPRINKLE

The following medications may interact with JADENU:

  • Do not take JADENU with aluminum-containing antacid preparations
  • JADENU increases the exposure of repaglinide. Consider repaglinide dose reduction and monitor blood glucose levels
  • Avoid the use of JADENU with theophylline as theophylline levels could be increased
  • JADENU increases exposure of busulfan. Monitor plasma concentrations of busulfan when coadministered with JADENU to allow dose adjustment of busulfan, as needed


Novartis Pharmaceuticals

Is JADENU SPRINKLE safe in pregnancy?

Is JADENU SPRINKLE safe in pregnancy?

It is not known if JADENU can harm your unborn baby. Hormonal forms of birth control may not be as effective if used during treatment with JADENU. You could become pregnant. Talk to your healthcare provider about other birth control options that you can use during this time. Tell your healthcare provider right away if you become pregnant during treatment with JADENU.


What to do if you missed your JADENU SPRINKLE dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

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NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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