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Clolar is the brand name for clofarabine IV infusion.

Clolar is available as a 20 mg/20 mL single use vial.

Clolar is used to treat acute lymphoblastic leukemia (ALL), a cancer of the white blood cells, in patients who have already used at least 2 other cancer medicines.

Clolar is an antineoplastic (cancer) medicine. It interferes with the growth of cancer cells, which are eventually destroyed by the body.

You will receive this medicine while you or your child are in a hospital or cancer treatment center. A doctor or other trained health professional will give you this medicine. This medicine is given through a needle placed in one of your veins. The medicine is usually given every day for 5 days. Each treatment usually takes about 2 hours.

Clolar is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Clolar:

• Nausea
• Vomiting
• Diarrhea
• Febrile neutropenia
• Headache
• Rash
• Itching
• Fever
• Fatigue
• Anxiety
• Flushing

Serious side effects are rare with Clolar. This medication may increase your risk to bruise or bleed. Call your care team if you notice any unusual bleeding. This medication may increase your risk of getting an infection. Call your care team for advice if you get a fever, chills, sore throat, or other symptoms of a cold or flu.
This medicine may cause serious skin reactions. They can happen weeks to months after starting the medicine. Contact your care team right away if you notice fevers or flu-like symptoms with a rash.

• There are no major drug interactions listed for Clolar. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking

Genzyme Corporation

Clolar may cause fetal harm when administered to a pregnant woman. Women of childbearing potential should be advised to avoid becoming pregnant while receiving treatment with Clolar. All patients should be advised to use effective contraceptive measures to prevent pregnancy.

• Clofarabine