Promethazine Generic

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*Based on the difference between the U&C price submitted and the price the patient paid, as of April 2023.

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  2. Promethazine HCL
    Generic for Phenergan
    30 tablets $4.2 USD
    Save $13.80
  3. Promethazine HCL
    Generic for Phenergan
    30 tablets $4.2 USD
    Save $13.80
  4. Promethazine HCL
    Generic for Phenergan
    30 tablets $4.8 USD
    Save $13.20
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Do you need a prescription for promethazine?

Yes, promethazine is only available with a valid physician Rx.

How much is promethazine without Insurance in the US?

Our website gives two competitive savings options to US customers who wish to purchase promethazine, as either a brand or generic, if available. The first is access to medications through our mail-order online pharmacy. The second is by using the Now Patient Rx Advantage Card, which can be used in over 65,000 pharmacies nationwide, across America. If you are insured, then in most cases, the cash price will be significantly cheaper than the copay.

What will my out-of-pocket cost be for promethazine in the US?

There are no out-of-pocket (OOP) costs because we are currently only offering a cash-based option to purchase medications.

Is Now Patient a promethazine savings card?

Yes. Save up to 90% on your promethazine with the FREE Now Patient Rx Advantage card*.
*Based on the difference between the U&C submitted by the pharmacy and the price the patients pay.

Can you handle Rx transfers for home delivery in the US?

Yes. If you use the mail-order online pharmacy option, then we can handle requests by you to have your prescription transferred to our pharmacy for home delivery. We can even help you manage your refills by giving you timely reminders, so you do not run out of your medication.

Is Now Patient a promethazine coupon provider in the US?

No. Now Patient does not provide promethazine coupons or FREE promethazine samples.

Do you accept commercial, Medicare or Medicaid coverage for promethazine in the US?

No. Currently, we only offer cash-based options for purchase, therefore we do not require your insurance benefit details. In the future, our plan is to be able to handle commercial insurance, Medicare and Medicaid including cases where you have multiple health plans that provide benefit coverage (e.g. Medicaid and Commercial). We also anticipate being able to handle more complex scenarios such as using primary insurance combined with a manufacturer copay assistance program.

Does Now Patient work with Medicare?

Our cash-based prices for medications are typically cheaper than Medicare copays. We do not bill Medicare Part D (standalone drug coverage) or Medicare Advantage (combined health and drug coverage). When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

Does Now Patient work with Commercial Insurance?

Our cash-based prices for medications are typically cheaper than commercial plan copays. We do not bill your commercial plan. When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

What should you do if you use too much promethazine?


Call your doctor right away or seek immediate medical attention if your symptoms do not improve or they become worse after using promethazine. You can also call 800-222-1222 to reach the American Association of Poison Control Centers or use its online resource if you think you’ve used too much promethazine. But if you have severe symptoms, call 911 (or your local emergency number) immediately or go to the nearest emergency room.


If you think it is an emergency, call 999 or find your nearest A&E
If you need help now, but it’s not an emergency go to 111.nhs.uk or call 111. Alternatively you can speak to one of our pharmacists or use the Now Patient app to make an appointment with your GP.

What should I do if I miss my dose?

There are occasions when people forget to take their medication at correct prescribed times. This may not only have an effect on potentially making the medication less effective but it may also inadvertently lead to taking doses too close together, thereby increasing the risks of side effects.

Click here to find out what to do if you forgot to take your medication

US brand name of promethazine and manufacturer

Promethazine is available in the US under various brand names, including Phenergan and Promethegan. It is manufactured by multiple pharmaceutical companies.

UK brand name of promethazine and manufacturer

Promethazine is available in the UK under the brand name Avomine, Phenergan. It is manufactured by Alliance Pharmaceuticals Ltd.

Is promethazine available in the UK on the NHS?

Yes, promethazine is available on the NHS in the UK. It can be prescribed by healthcare professionals for eligible patients.  Some brands are also available over-the-counter.

Prescription requirement for promethazine

Promethazine is a prescription medication and requires a prescription from a healthcare provider.

FDA approval of promethazine

Promethazine has received FDA approval for various uses, including the treatment of allergy symptoms, motion sickness, nausea, and vomiting.

Active ingredient of promethazine and mechanism of action

Promethazine is an antihistamine medication that works by blocking the effects of histamine, a substance produced by the body during an allergic reaction. It also has sedative, antipsychotic and antiemetic properties, which help relieve nausea and vomiting.

Uses of promethazine

Promethazine is a phenothiazine, primarily used for the following purposes:

  • Relief of allergy symptoms, such as itching, sneezing, allergic conjunctivitis, and runny nose
  • Prevention and treatment of motion sickness
  • Management of nausea and vomiting, including that caused by surgery, chemotherapy, or certain medications

Forms of promethazine

Promethazine is available in various forms, including oral tablets, oral liquid, rectal suppositories, and injectable formulations. The specific form and strength will depend on the intended use and the formulation of the medication.

Dosage of promethazine

The dosage of promethazine will vary depending on the specific condition being treated, individual patient characteristics, and response to therapy. It is important to follow the dosage instructions provided by your healthcare provider.

Precautions and warnings for promethazine

  • Promethazine hydrochloride (hcl) may cause drowsiness or impair your ability to perform tasks that require alertness. Avoid driving or operating machinery until you know how promethazine affects you
  • It may interact with other medications, so it is important to inform your healthcare provider about all the medications you are taking, including prescription drugs, over-the-counter medications, and herbal supplements
  • Promethazine should not be used in children younger than 2 years old, as it may cause serious side effects
  • Use caution when using promethazine in elderly patients, as they may be more sensitive to its effects
  • Tell your doctor if you have any breathing problems, sleep apnea, bone marrow depression, glaucoma, an irregular heartbeat, high blood pressure, neuroleptic malignant syndrome, liver disease, or an enlarged prostate, before starting treatment
  • Promethazine passes into breast milk. Speak to your doctor before breast-feeding

Side effects of promethazine

Promethazine’s anticholinergic properties may cause side effects. Common side effects of promethazine may include:

  • Drowsiness
  • Dizziness
  • Blurred vision
  • Dry mouth
  • Constipation
  • Nausea

Promethazine may cause serious allergic reactions, with symptoms including hives, rash, itching, swelling of the face, tongue, or throat, and trouble breathing. Contact your healthcare provider if you experience severe or persistent adverse effects.

Interactions with other drugs

Promethazine may interact with other medications, including sedatives, tranquilizers, opioid pain relievers (such as codeine, and hydrocodone), other antihistamines (such as cetirizine or diphenhydramine), barbiturates (such as phenobarbital), other phenothiazines (such as prochlorperazine and chlorpromazine), and certain other antidepressants. It is important to inform your healthcare provider about all the medications you are taking to avoid potential drug interactions.



Now Patient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information in this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

Stefano Mirabello Medical Reviewer
Pharmacist / B.Pharm
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