Used for Hay Fever and Allergies

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Programs are suitable for individuals who want to buy promethazine without insurance, with insurance or for those who are underinsured. You can pay as little as $0 per fill.*

Manufactured by various FDA-approved generic manufacturers.

*Applicable to Drug Coupons & Patient Assistance Programs

This content is intended for US audiences only

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Updated on 24 Apr 2024

Learn more about promethazine

What dosages is promethazine available in?

What dosages is promethazine available in?

promethazine is available as a 12.5 mg, 25 mg, and 50 mg oral tablet and suppository as well as a 6.25 mg/5 ml oral syrup.

What is promethazine used for?

What is promethazine used for?

promethazine is an antihistamine and is used to treat the following:

  • Runny nose, watery eyes, and other symptoms of allergies
  • Runny or stuffy nose that isn’t caused by allergies
  • Rash, swelling, anaphylaxis, and other symptoms of an allergic reaction
  • Treatment or prevention of nausea and vomiting before and after surgery
  • Treatment or prevention of motion sickness
    Treatment of pain along with other pain medications after surgery
  • Help to relax your body and produce a light sleep, particularly before a procedure
How does promethazine work?

How does promethazine work?

promethazine is an antihistamine. It works by blocking a chemical called histamine from attaching to receptors (proteins) in your brain and throughout your body. When histamines are blocked, promethazine can help relieve symptoms of allergy, such as rash, watery eyes, and runny nose. It can also cause you to feel drowsy and calm before a surgery. Additionally, promethazine also blocks another chemical called acetylcholine, which helps to relieve symptoms of nausea, vomiting, and motion sickness.

How do I take promethazine?

How do I take promethazine?

promethazine is typically taken every 4 to 6 hours as needed. Your doose will depend on the condition being treated and dosage form being used.

Is it safe for me to take promethazine?

Is it safe for me to take promethazine?

promethazine is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in:

  • Pediatric patients less than two years of age.
    Comatose states, and in individuals known to be hypersensitive or to have had an idiosyncratic reaction to promethazine or to other phenothiazines. The treatment of lower respiratory tract symptoms including asthma
promethazine Common Side Effects

promethazine Common Side Effects

Common side effects of promethazine:

  • Feeling drowsy or tired
  • Dizziness
  • Confusion
  • Dry mouth
  • High or low blood pressure
  • Nervousness
  • Double vision
  • Burning
  • Pain
  • Rash
  • Swelling
promethazine Serious Side Effects

promethazine Serious Side Effects

Serious side effects are rare with promethazine. Contact your healthcare provider immediately if you experience any of the following.

  • Neuroleptic malignant syndrome (NMS): stiff muscles, high fever, sweating, changes in heartbeat, changes in heart rhythm, confusion
  • Breathing problems: stuffy nose, slowed breathing, breathing repeatedly stops
  • Excessive drowsiness
  • Seizures
  • Gangrene (injection only): purple or black skin, swelling, loss of sensation, sores or blisters that bleed
Effects of other drugs, drug classes and over-the-counter products on promethazine

Effects of other drugs, drug classes and over-the-counter products on promethazine

The following medications may interact with promethazine:

  • CNS Depressants: May increase, prolong, or intensify the sedative action of other central-nervous-system depressants, such as alcohol, sedatives/hypnotics (including barbiturates), narcotics, narcotic analgesics, general anesthetics, tricyclic antidepressants, and tranquilizers; therefore, such agents should be avoided or administered in reduced dosage to patients receiving promethazine HCl
  • Epinephrine: Epinephrine should NOT be used to treat hypotension associated with promethazine overdose.
  • Anticholinergics: Concomitant use of other agents with anticholinergic properties should be undertaken with caution
  • Monoamine Oxidase Inhibitors (MAOI): Drug interactions, including an increased incidence of extrapyramidal effects, have been reported when some MAOI and phenothiazines are used concomitantly
Who makes promethazine?

Who makes promethazine?

Various FDA-approved generic manufacturers

Is promethazine safe in pregnancy?

Is promethazine safe in pregnancy?

It is not known if promethazine will harm your unborn baby. You should talk to your healthcare provider before taking this medication if you are pregnant.


What to do if you missed your promethazine dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

Learn more about reporting side effects
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Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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