Save on Promethazine with Coupons, Discounts & Savings Programs

Promethazine is available as a 12.5 mg, 25 mg, and 50 mg oral tablet and suppository as well as a 6.25 mg/5 ml oral syrup.

Promethazine is an antihistamine and is used to treat the following:

• Runny nose, watery eyes, and other symptoms of allergies
• Runny or stuffy nose that isn’t caused by allergies
• Rash, swelling, anaphylaxis, and other symptoms of an allergic reaction
• Treatment or prevention of nausea and vomiting before and after surgery
• Treatment or prevention of motion sickness
  Treatment of pain along with other pain medications after surgery
• Help to relax your body and produce a light sleep, particularly before a procedure

Promethazine is an antihistamine. It works by blocking a chemical called histamine from attaching to receptors (proteins) in your brain and throughout your body. When histamines are blocked, Promethazine can help relieve symptoms of allergy, such as rash, watery eyes, and runny nose. It can also cause you to feel drowsy and calm before a surgery. Additionally, Promethazine also blocks another chemical called acetylcholine, which helps to relieve symptoms of nausea, vomiting, and motion sickness.

Promethazine is typically taken every 4 to 6 hours as needed. Your doose will depend on the condition being treated and dosage form being used.

Promethazine is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in:

• Pediatric patients less than two years of age.
  Comatose states, and in individuals known to be hypersensitive or to have had an idiosyncratic reaction to Promethazine or to other phenothiazines. The treatment of lower respiratory tract symptoms including asthma

Common side effects of Promethazine:

• Feeling drowsy or tired
• Dizziness
• Confusion
• Dry mouth
• High or low blood pressure
• Nervousness
• Double vision
• Burning
• Pain
• Rash
• Swelling

Serious side effects are rare with Promethazine. Contact your healthcare provider immediately if you experience any of the following.

• Neuroleptic malignant syndrome (NMS): stiff muscles, high fever, sweating, changes in heartbeat, changes in heart rhythm, confusion
• Breathing problems: stuffy nose, slowed breathing, breathing repeatedly stops
• Excessive drowsiness
• Seizures
• Gangrene (injection only): purple or black skin, swelling, loss of sensation, sores or blisters that bleed

The following medications may interact with Promethazine:

• CNS Depressants: May increase, prolong, or intensify the sedative action of other central-nervous-system depressants, such as alcohol, sedatives/hypnotics (including barbiturates), narcotics, narcotic analgesics, general anesthetics, tricyclic antidepressants, and tranquilizers; therefore, such agents should be avoided or administered in reduced dosage to patients receiving Promethazine HCl
• Epinephrine: Epinephrine should NOT be used to treat hypotension associated with Promethazine overdose.
• Anticholinergics: Concomitant use of other agents with anticholinergic properties should be undertaken with caution
• Monoamine Oxidase Inhibitors (MAOI): Drug interactions, including an increased incidence of extrapyramidal effects, have been reported when some MAOI and phenothiazines are used concomitantly

Various FDA-approved generic manufacturers

It is not known if Promethazine will harm your unborn baby. You should talk to your healthcare provider before taking this medication if you are pregnant.

• Phenergan