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MEDICAL INFORMATION
Phenergan Key Facts
Other Related Names or Treatments
Avomine
About Phenergan
Phenergan contains promethazine hydrochloride as its active ingredient. It is an antihistamine with anti-emetic and anticholinergic effects on the body. Phenergan is used to treat insomnia, allergies such as hay fever, symptoms of the common cold (when mixed with paracetamol, dextromethorphan or pseudoephedrine), and the prevention of travel sickness.
Phenergan is also available as alternative brands of promethazine such as Sominex and Avomine. NowPatient offers Phenergan as a treatment for travel sickness only, following an online consultation with a prescribing clinician.
Key facts of Phenergan
- For the treatment of motion sickness
- Take Phenergan the night before a long journey or 1 or 2 hours before a short journey
- Phenergan has some common side effects which include drowsiness, headaches, and dizziness
- Do not drink alcohol when taking Phenergan as this may increase the risk of side effects
- It can be dangerous if you take Phenergan with certain medications like sleeping tablets. If you’re not sure if it is safe, discuss this with the prescribing clinician
Who is Phenergan suitable for?
Phenergan is suitable for most adults.
Who is Phenergan not suitable for?
Phenergan may not be suitable for some people. To make sure it’s safe for you, speak to the prescribing clinician before taking Phenergan if you:
- Have previously had an allergic reaction to promethazine, or other phenothiazines
- Have glaucoma
- Have high blood pressure
- Have epilepsy
- Have liver, bladder or kidney problems
- Have a weak immune system (bone marrow depression)
- Have asthma, chronic obstructive pulmonary disease, or sleep apnea
- Are pregnant or trying to get pregnant. Promethazine can affect home pregnancy tests
How and where to get Phenergan 25mg tablets?
You can buy Phenergan safely and securely from NowPatient. You can start a consultation today for free and if you qualify for treatment, you only pay for the cost of the medication. Delivery is made to your home or office from our registered pharmacy.
Our service is certified, safe and effective, and we only ever treat conditions. If you book a consultation with a prescribing clinician for the treatment of motion sickness, you can discuss if Phenergan is a suitable treatment option for you.
At the end of the consultation, the clinician will decide if a treatment plan is suitable for you. If it is, the clinician will issue you with a prescription which can then be ordered, paid for and delivered directly to your chosen address by NowPatient.
Dosage and strength for Phenergan for travel sickness
Phenergan is available as tablets, liquid, or as injection for intramuscular, or intravenous administration. The dosage for the tablets, solutions, and suppository is 5 mg to 25 mg. Phenergan is available as 25mg tablets when used for the treatment of travel sickness.
Information about how to take Phenergan for travel sickness
For the prevention of motion sickness, take 25mg 1 or 2 hours before a short journey or 25mg the night before a long journey. When treating motion sickness, take 25mg immediately and 25mg the same evening, then 25mg the next day, if needed. Read the patient information leaflet supplied with your medication for further information, or speak to your healthcare provider for further medical advice.
What happens if you take too much Phenergan?
If you take more than prescribed, then it can lead to some unpleasant side effects. Phenergan can cause symptoms such as respiratory depression, CNS depression, hypotension, unconsciousness, and sudden death, especially in patients under 2 years of age.
You should talk to your doctor or reach out to one of our prescribing clinicians, if you have taken too much Phenergan and you experience any of the following side effects:
- Drowsiness
- An irregular heartbeat
- Breathing problems
In serious cases, you can become unconscious or have seizures or fits and may need emergency treatment in hospital.
What are the side effects of Phenergan?
Side effects of Phenergan are split into common and serious.
Common side effects include:
- Daytime tiredness
- Blurred vision
- Upset stomach, loss of appetite, diarrhea, constipation
- Nightmares
- Dizziness
- Headaches
- Skin sensitivity to sunlight (Use sunscreen and wear protective clothing when outdoors, avoid tanning booths and sunlamps)
- Older adults may experience confusion, dry mouth, blurred vision, and difficulty urinating
- Serious side effects include:
- Yellowing of your eyes which may be a sign of liver problems (jaundice)
- Bruising or bleeding easily
- Muscle stiffness or shaking
- Unusual face or tongue movements
- Neuroleptic malignant syndrome (a brain disorder)
If you experience any serious side effects, you should contact NHS 111.
If you experience a serious allergic reaction such as anaphylaxis with the signs shown below you should contact emergency services on 999.
- HIves
- Your lips, mouth, throat or tongue suddenly become swollen
- You’re breathing very fast or struggling to breathe (you may become very wheezy or feel like you’re choking or gasping for air)
- Your throat feels tight or you’re struggling to swallow
- Your skin, tongue or lips turn blue, grey or pale (if you have black or brown skin, this may be easier to see on the palms of your hands or soles of your feet)
- You suddenly become very confused, drowsy or dizzy
- Someone faints and cannot be woken up
Information about taking Phenergan at the same time as other medications or herbal supplements
There may be drug interactions when taking herbal supplements with Phenergan, especially those that cause sleepiness, or dry mouth. Also tell your doctor if you are taking:
- Antidepressants such as monoamine oxidase inhibitors
- Opioids, such as codeine, morphine, or oxycodone
- Other drowsy antihistamines such as chlorphenamine and diphenhydramine
Also, speak with a healthcare professional before you take Phenergan with any other painkillers or medicines.
How long does Phenergan take to work?
Phenergan will start to work within 20 minutes and may continue to work for up to 12 hours.
Can Phenergan be taken long term?
You should only take Phenergan for short term use, unless your doctor says it’s ok to take it longer.
Is Phenergan addictive?
Phenergan is not addictive, but do not take it for longer than advised. If you have taken Phenergan for a long time and suddenly stop, you may feel dizzy or sick. Speak to your doctor before stopping Phenergan if you have taken it for a long time.
Is there a herbal Phenergan?
No. Herbal Phenergan does not exist. If you have been marketed such a formulation, it may be fake.
Can women use Phenergan when pregnant or breastfeeding?
Yes. Phenergan is not harmful to your baby. Also, if your doctor says your baby is healthy, Phenergan can be used during breastfeeding.
Should I avoid any particular food or drink when taking Phenergan?
You can eat and drink normally when taking Phenergan tablets. However, do not drink alcohol when taking Phenergan as this may increase the risk of side effects.
Alternatives to Phenergan
Alternatives for the treatment of motion sickness include Avomine and Scopoderm (scopolamine).
Sources
- Avomine available online from Access Doctor
- Promethazine: drowsy (sedating) antihistamine that relieves allergy symptoms – NHS
Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
Related Articles
FAQs
Answers to Popular Questions About Phenergan
What is Phenergan?
Phenergan is a brand name for promethazine hydrochloride, a first-generation antihistamine. It is available as 10 mg and 25 mg tablets, liquid (elixir), and injection. Phenergan has multiple uses: allergy relief (hay fever, urticaria), short-term insomnia treatment, motion sickness prevention, and nausea/vomiting relief. Phenergan 10 mg and 25 mg tablets and elixir are available over the counter from pharmacies.
How does Phenergan work?
Promethazine blocks histamine H1 receptors, providing antihistamine effects for allergy symptoms. It also crosses the blood-brain barrier, causing sedation (which is useful for insomnia) and has anti-emetic effects by acting on the vomiting centre and vestibular system (useful for motion sickness and nausea). Its anticholinergic properties contribute to its anti-emetic and drying effects.
How do I take Phenergan for different conditions?
For allergies: 25 mg at night, or 10 mg twice daily. For insomnia: 25–50 mg at bedtime (short-term only — up to 7–14 days). For motion sickness: 25 mg the night before travel, then 25 mg on the day of travel. For nausea: 25 mg at night, repeated if necessary. Always follow the dose instructions on the pack or your prescriber’s guidance. Take the tablets with water.
What are the side effects of Phenergan?
The most common side effect is drowsiness, which is significant and long-lasting (up to 12 hours). Do not drive or operate machinery after taking Phenergan. Other side effects include dry mouth, blurred vision, constipation, urinary retention, and dizziness. Avoid alcohol as it increases sedation. Paradoxical excitation (restlessness, insomnia) can occur in children.
Can I buy Phenergan without a prescription?
Yes, Phenergan tablets and elixir are available over the counter from pharmacies for adults and children over 6 years (depending on formulation). The pharmacist will check suitability and advise on correct dosing. Higher doses or use for conditions beyond OTC indications may require a prescription.
How can I get Phenergan?
Phenergan is available over the counter from pharmacies for allergies, short-term insomnia, and motion sickness. For specific medical use or higher doses, a prescription from your GP or NowPatient may be needed.
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