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Pramlintide Acetate is available as a:

• 1.5 mL pramlintide acetatePen 60 disposable multidose pen-injector, (1000 mcg/mL) for 15, 30, 45, and 60 mcg doses
• 2.7 mL pramlintide acetatePen 120 disposable multidose pen-injector, (1000 mcg/mL) for 60 and 120 mcg doses

Pramlintide Acetate is an amylin analog that is used to treat:

• Type 1 diabetes
• Type 2 diabetes

Pramlintide Acetate is an amylin analog. It’s a man-made version of human amylin. Amylin helps lower blood sugar in three ways: making you feel full after meals, lowering the amount of sugars released by your body, and lowering the amount of calories your body absorbs.

Pramlintide Acetate is typically dosed as follows:

• Type 1 diabetes: The medication starts at 15 mcg injected subcutaneously (under the skin) before major meals. If you don’t feel nauseous after three days, the dose is raised (usually around 30 mcg to 60 mcg before major meals)
• Type 2 diabetes: The medication starts at 60 mcg injected subcutaneously (under the skin) before major meals. If you don’t feel nauseous after three days, the dose is raised to 120 mcg before major meals

Pramlintide Acetate is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:

• Prior serious hypersensitivity reaction to Pramlintide Acetate or its ingredients
• Hypoglycemia unawareness
• Confirmed gastroparesis

Common side effects of Pramlintide Acetate:

• Nausea
• Loss of appetite
• Headache
• Vomiting
• Tiredness
• Joint pain
• Dizziness

Serious side effects are rare with Pramlintide Acetate. Contact your healthcare provider immediately if you experience any of the following.

• Allergic reactions

The following medications may interact with Pramlintide Acetate:

• Insulin: Pramlintide Acetate and insulin must not be mixed and must be administered as separate injections
• Oral Medications: Pramlintide Acetate has the potential to delay the absorption of concomitantly administered oral medications. Oral medications should be administered at least 1 hour prior to Pramlintide Acetate injection or 2 hours after Pramlintide Acetate injection
• Drugs Affecting Gastrointestinal Motility: Due to its effects on gastric emptying, Pramlintide Acetate should not be considered for patients taking medications that alter gastrointestinal motility (e.g., anticholinergic agents such as atropine) or medications that slow the intestinal absorption of nutrients (e.g., alpha-glucosidase inhibitors).

Drugs Affecting Glucose Metabolism:

• The following are examples of medications that may increase the susceptibility to hypoglycemiawhen administered with Pramlintide Acetate: oral anti-diabetic products, angiotensin converting enzyme
• (ACE) inhibitors, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors pentoxifylline, propoxyphene, salicylates, somatostatin analogs, and sulfonamide antibiotics
• Pramlintide Acetate and these drugs should be coadministered with caution

Various FDA-approved generic manufacturers

It is not known if Pramlintide Acetate will harm your unborn baby. You and your healthcare provider should decide how to best control your blood sugar levels during pregnancy.

• Symlin