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Manufactured by AbbVie Inc.

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Jamie Winn NowPatientGreen tick
Updated on 26 Apr 2024

ORILISSA Uses, Side Effects, Interactions, Warnings & Dosing



ORILISSA is the brand name for elagolix and is available as an oral tablet.

What dosages is ORILISSA available in?

What dosages is ORILISSA available in?

ORILISSA is available as a 150 mg and 200 mg oral tablet.

What is ORILISSA used for?

What is ORILISSA used for?

ORILISSA is a gonadotropin-releasing hormone (GnRH) antagonist and is used to treat moderate to severe pain caused by endometriosis.

How does ORILISSA work?

How does ORILISSA work?

ORILISSA is a gonadotropin-releasing hormone (GnRH) antagonist, meaning that it attaches to and blocks GnRH receptors (a protein that responds to signals) in your pituitary gland. This lowers the release of hormones that cause pain due to endometriosis.

How do I take ORILISSA?

How do I take ORILISSA?

ORILISSA is typically started at 150 mg by mouth once daily for 24 months. Your dose might differ if you have dyspareunia (genital pain during sex) or liver problems.

Is it safe for me to take ORILISSA?

Is it safe for me to take ORILISSA?

ORILISSA is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if any of the following apply.

  • Pregnancy
  • Known osteoporosis
  • Severe hepatic impairment
  • Organic anion transporting polypeptide (OATP) 1B1 inhibitors that significantly increase elagolix plasma concentrations
  • Hypersensitivity reactions
ORILISSA Common Side Effects

ORILISSA Common Side Effects

Common side effects of ORILISSA:

  • Hot flush
  • Headache
  • Nausea
  • Trouble sleeping
  • Mood swings
  • Missing menstrual period
  • Depressed mood
  • Anxiety
  • Joint pain
ORILISSA Serious Side Effects

ORILISSA Serious Side Effects

Serious side effects are rare with ORILISSA. Contact your healthcare provider immediately if you experience any of the following.

  • Liver damage: yellowing of your skin and whites of your eyes, stomach pain, nausea, vomiting, loss of appetite, dark urine, tiredness
  • Serious allergic reaction: rash, swelling of lips, tongue, or throat, difficulty breathing
Effects of other drugs, drug classes and over-the-counter products on ORILISSA

Effects of other drugs, drug classes and over-the-counter products on ORILISSA

The following medications may interact with ORILISSA:

  • Increase monitoring of digoxin concentrations and potential signs and symptoms of clinical toxicity when initiating ORILISSA in patients who are taking digoxin If ORILISSA is discontinued, increase monitoring of digoxin concentrations.
  • Monitor lipid levels and adjust the dose of rosuvastatin, if necessary
  • Advise women to use effective non-hormonal contraception during treatment with ORILISSA and for 28 days after discontinuing ORILISSA
  • Concomitant use of ORILISSA 200 mg twice daily and strong CYP3A inhibitors for more than 1 month is not recommended. Limit concomitant use of ORILISSA 150 mg once daily and strong CYP3A inhibitors to 6 months
  • Co-administration of ORILISSA with strong CYP3A inducers may decrease elagolix plasma concentrations and may result in a decrease of the therapeutic effects of ORILISSA
  • Concomitant use of ORILISSA 200 mg twice daily and rifampin is not recommended. Limit concomitant use of ORILISSA 150 mg once daily and rifampin to 6 months
Who makes ORILISSA?

Who makes ORILISSA?

AbbVie Inc.

Is ORILISSA safe in pregnancy?

Is ORILISSA safe in pregnancy?

Use of ORILISSA is contraindicated in pregnant women. Exposure to ORILISSA early in pregnancy may increase the risk of early pregnancy loss. Discontinue ORILISSA if pregnancy
occurs during treatment. There is a pregnancy registry that monitors pregnancy outcomes in women exposed to
ORILISSA during pregnancy . Healthcare providers are encouraged to register patients, or pregnant women may enroll themselves in the registry by calling 1-833-782-7241 or
visiting Bloom pregnancy registry  


What to do if you missed your ORILISSA dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

Learn more about reporting side effects
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NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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