elagolix
Used for Cancer
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Manufactured by various FDA-approved generic manufacturers.
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elagolix Uses, Side Effects, Interactions, Warnings & Dosing
What dosages is elagolix available in?
elagolix is available as a 150 mg and 200 mg oral tablet.
What is elagolix used for?
elagolix is a gonadotropin-releasing hormone (GnRH) antagonist and is used to treat moderate to severe pain caused by endometriosis.
How does elagolix work?
elagolix is a gonadotropin-releasing hormone (GnRH) antagonist, meaning that it attaches to and blocks GnRH receptors (a protein that responds to signals) in your pituitary gland. This lowers the release of hormones that cause pain due to endometriosis.
How do I take elagolix?
elagolix is typically started at 150 mg by mouth once daily for 24 months. Your dose might differ if you have dyspareunia (genital pain during sex) or liver problems.
Is it safe for me to take elagolix?
elagolix is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if any of the following apply.
- Pregnancy
- Known osteoporosis
- Severe hepatic impairment
- Organic anion transporting polypeptide (OATP) 1B1 inhibitors that significantly increase elagolix plasma concentrations
- Hypersensitivity reactions
elagolix Common Side Effects
Common side effects of elagolix:
- Hot flush
- Headache
- Nausea
- Trouble sleeping
- Mood swings
- Missing menstrual period
- Depressed mood
- Anxiety
- Joint pain
elagolix Serious Side Effects
Serious side effects are rare with elagolix. Contact your healthcare provider immediately if you experience any of the following.
- Liver damage: yellowing of your skin and whites of your eyes, stomach pain, nausea, vomiting, loss of appetite, dark urine, tiredness
- Serious allergic reaction: rash, swelling of lips, tongue, or throat, difficulty breathing
Effects of other drugs, drug classes and over-the-counter products on elagolix
The following medications may interact with elagolix:
- Increase monitoring of digoxin concentrations and potential signs and symptoms of clinical toxicity when initiating elagolix in patients who are taking digoxin If elagolix is discontinued, increase monitoring of digoxin concentrations.
- Monitor lipid levels and adjust the dose of rosuvastatin, if necessary
- Advise women to use effective non-hormonal contraception during treatment with elagolix and for 28 days after discontinuing elagolix
- Concomitant use of elagolix 200 mg twice daily and strong CYP3A inhibitors for more than 1 month is not recommended. Limit concomitant use of elagolix 150 mg once daily and strong CYP3A inhibitors to 6 months
- Co-administration of elagolix with strong CYP3A inducers may decrease elagolix plasma concentrations and may result in a decrease of the therapeutic effects of elagolix
- Concomitant use of elagolix 200 mg twice daily and rifampin is not recommended. Limit concomitant use of elagolix 150 mg once daily and rifampin to 6 months
Who makes elagolix?
Various FDA-approved generic manufacturers
Is elagolix safe in pregnancy?
Use of elagolix is contraindicated in pregnant women. Exposure to elagolix early in pregnancy may increase the risk of early pregnancy loss. Discontinue elagolix if pregnancy
occurs during treatment. There is a pregnancy registry that monitors pregnancy outcomes in women exposed to
elagolix during pregnancy . Healthcare providers are encouraged to register patients, or pregnant women may enroll themselves in the registry by calling 1-833-782-7241 or
visiting Bloom pregnancy registry
What to do if you missed your elagolix dose
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effectsDrug Savings Tips
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Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
Things to know
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