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Manufactured by Neurocrine Biosciences, Inc.

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Jamie Winn NowPatientGreen tick
Updated on 26 Apr 2024

ONGENTYS Uses, Side Effects, Interactions, Warnings & Dosing



ONGENTYS is the brand name for opicapone oral capsules.

What dosages is ONGENTYS available in?

What dosages is ONGENTYS available in?

ONGENTYS is available as 25 mg and 50 mg oral capsules.

What is ONGENTYS used for?

What is ONGENTYS used for?

ONGENTYS is a COMT inhibitor and is used to add-on treatment for people with Parkinson’s disease taking carbidopa/levodopa medications (e.g., Sinemet, Rytary) who experience “wearing-off” episodes.

How does ONGENTYS work?

How does ONGENTYS work?

ONGENTYS is a catechol-O-methyltransferase (COMT) inhibitor. COMT is a protein in your body that breaks down a commonly used Parkinson’s medication called levodopa. This causes levodopa to be less effective at relieving symptoms of Parkinson’s disease, which occur due to low dopamine levels in the brain. By blocking COMT, ONGENTYS allows levodopa to reach and stay at higher levels in the body. This means more levodopa can be converted into dopamine in the brain to relieve PD symptoms.

How do I take ONGENTYS?

How do I take ONGENTYS?

The typical dose is 50 mg by mouth once per day at bedtime. For people with moderate liver problems, the typical dose is 25 mg by mouth once per day.

Is it safe for me to take ONGENTYS?

Is it safe for me to take ONGENTYS?

ONGENTYS is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:

  • Concomitant use of non-selective monoamine oxidase (MAO) inhibitors.
  • History of pheochromocytoma, paraganglioma, or other catecholamine secreting neoplasms
ONGENTYS Common Side Effects

ONGENTYS Common Side Effects

Common side effects of ONGENTYS:

  • Involuntary movements
  • Constipation
  • Weight loss
ONGENTYS Serious Side Effects

ONGENTYS Serious Side Effects

Serious side effects are rare with ONGENTYS. Contact your healthcare provider immediately if you experience any of the following.

  • Excessive sleepiness
  • Low blood pressure: dizziness, tiredness, feeling faint
  • Symptoms after stopping the medication suddenly: fever, stiff or rigid muscles, confusion
Effects of other drugs, drug classes and over-the-counter products on ONGENTYS

Effects of other drugs, drug classes and over-the-counter products on ONGENTYS

The following medications may interact with ONGENTYS:

  • Non-Selective Monoamine Oxidase (MAO) Inhibitors: Both ONGENTYS and non-selective MAO inhibitors (e.g., phenelzine, isocarboxazid, and tranylcypromine) inhibit catecholamine metabolism, leading to increased levels of catecholamines. Concomitant use may increase the risk of possible arrhythmias, increased heart rate, and excessive changes in blood pressure
  • Concomitant use of ONGENTYS with non-selective MAO inhibitors is contraindicated. Selective MAO-B inhibitors can be used concomitantly with ONGENTYS
  • Drugs Metabolized by Catechol-O-Methyltransferase (COMT): Concomitant use of ONGENTYS with drugs metabolized by COMT may affect the pharmacokinetics of those drugs, which may increase the risk of possible arrhythmias, increased heart rate, and excessive changes in blood pressure. Drugs known to be metabolized by COMT should be administered with caution. Monitor for changes in heart rate, rhythm, and blood pressure in patients
  • concomitantly treated with ONGENTYS and drugs metabolized by COMT.
Who makes ONGENTYS?

Who makes ONGENTYS?

Neurocrine Biosciences, Inc.

Is ONGENTYS safe in pregnancy?

Is ONGENTYS safe in pregnancy?

Based on animal data, ONGENTYS may cause fetal harm. Tell your healthcare provider if you become pregnant while taking ONGENTYS.


What to do if you missed your ONGENTYS dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

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NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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