opicapone
Used for Parkinson’s Disease
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Manufactured by various FDA-approved generic manufacturers.
*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.
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opicapone Uses, Side Effects, Interactions, Warnings & Dosing
What dosages is opicapone available in?
opicapone is available as 25 mg and 50 mg oral capsules.
What is opicapone used for?
opicapone is a COMT inhibitor and is used to add-on treatment for people with Parkinson’s disease taking carbidopa/levodopa medications (e.g., Sinemet, Rytary) who experience “wearing-off” episodes.
How does opicapone work?
opicapone is a catechol-O-methyltransferase (COMT) inhibitor. COMT is a protein in your body that breaks down a commonly used Parkinson’s medication called levodopa. This causes levodopa to be less effective at relieving symptoms of Parkinson’s disease, which occur due to low dopamine levels in the brain. By blocking COMT, opicapone allows levodopa to reach and stay at higher levels in the body. This means more levodopa can be converted into dopamine in the brain to relieve PD symptoms.
How do I take opicapone?
The typical dose is 50 mg by mouth once per day at bedtime. For people with moderate liver problems, the typical dose is 25 mg by mouth once per day.
Is it safe for me to take opicapone?
opicapone is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:
- Concomitant use of non-selective monoamine oxidase (MAO) inhibitors.
- History of pheochromocytoma, paraganglioma, or other catecholamine secreting neoplasms
opicapone Common Side Effects
Common side effects of opicapone:
- Involuntary movements
- Constipation
- Weight loss
opicapone Serious Side Effects
Serious side effects are rare with opicapone. Contact your healthcare provider immediately if you experience any of the following.
- Excessive sleepiness
- Low blood pressure: dizziness, tiredness, feeling faint
- Symptoms after stopping the medication suddenly: fever, stiff or rigid muscles, confusion
Effects of other drugs, drug classes and over-the-counter products on opicapone
The following medications may interact with opicapone:
- Non-Selective Monoamine Oxidase (MAO) Inhibitors: Both opicapone and non-selective MAO inhibitors (e.g., phenelzine, isocarboxazid, and tranylcypromine) inhibit catecholamine metabolism, leading to increased levels of catecholamines. Concomitant use may increase the risk of possible arrhythmias, increased heart rate, and excessive changes in blood pressure
- Concomitant use of opicapone with non-selective MAO inhibitors is contraindicated. Selective MAO-B inhibitors can be used concomitantly with opicapone
- Drugs Metabolized by Catechol-O-Methyltransferase (COMT): Concomitant use of opicapone with drugs metabolized by COMT may affect the pharmacokinetics of those drugs, which may increase the risk of possible arrhythmias, increased heart rate, and excessive changes in blood pressure. Drugs known to be metabolized by COMT should be administered with caution. Monitor for changes in heart rate, rhythm, and blood pressure in patients
- concomitantly treated with opicapone and drugs metabolized by COMT.
Who makes opicapone?
Various FDA-approved generic manufacturers
Is opicapone safe in pregnancy?
Based on animal data, opicapone may cause fetal harm. Tell your healthcare provider if you become pregnant while taking opicapone.
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effects
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Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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