Ondansetron Generic

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*Based on the difference between the U&C price submitted and the price the patient paid, as of April 2023.

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  2. Ondansetron
    Generic for Zofran
    30 tablets $4.5 USD
    Save $105.30
  3. Ondansetron
    Generic for Zofran
    60 tablets $6.3 USD
    Save $213.30
  4. Ondansetron ODT
    Generic for Zofran ODT
    30 tablets $8.7 USD
    Save $159.30
  5. Ondansetron ODT
    Generic for Zofran ODT
    30 tablets $8.7 USD
    Save $159.30
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Do you need a prescription for ondansetron?

Yes, ondansetron is only available with a valid physician Rx.

How much is ondansetron without Insurance in the US?

Our website gives two competitive savings options to US customers who wish to purchase ondansetron, as either a brand or generic, if available. The first is access to medications through our mail-order online pharmacy. The second is by using the Now Patient Rx Advantage Card, which can be used in over 65,000 pharmacies nationwide, across America. If you are insured, then in most cases, the cash price will be significantly cheaper than the copay.

What will my out-of-pocket cost be for ondansetron in the US?

There are no out-of-pocket (OOP) costs because we are currently only offering a cash-based option to purchase medications.

Is Now Patient a ondansetron savings card?

Yes. Save up to 90% on your ondansetron with the FREE Now Patient Rx Advantage card*.
*Based on the difference between the U&C submitted by the pharmacy and the price the patients pay.

Can you handle Rx transfers for home delivery in the US?

Yes. If you use the mail-order online pharmacy option, then we can handle requests by you to have your prescription transferred to our pharmacy for home delivery. We can even help you manage your refills by giving you timely reminders, so you do not run out of your medication.

Is Now Patient a ondansetron coupon provider in the US?

No. Now Patient does not provide ondansetron coupons or FREE ondansetron samples.

Do you accept commercial, Medicare or Medicaid coverage for ondansetron in the US?

No. Currently, we only offer cash-based options for purchase, therefore we do not require your insurance benefit details. In the future, our plan is to be able to handle commercial insurance, Medicare and Medicaid including cases where you have multiple health plans that provide benefit coverage (e.g. Medicaid and Commercial). We also anticipate being able to handle more complex scenarios such as using primary insurance combined with a manufacturer copay assistance program.

Does Now Patient work with Medicare?

Our cash-based prices for medications are typically cheaper than Medicare copays. We do not bill Medicare Part D (standalone drug coverage) or Medicare Advantage (combined health and drug coverage). When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

Does Now Patient work with Commercial Insurance?

Our cash-based prices for medications are typically cheaper than commercial plan copays. We do not bill your commercial plan. When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

What should you do if you use too much ondansetron?


Call your doctor right away or seek immediate medical attention if your symptoms do not improve or they become worse after using ondansetron. You can also call 800-222-1222 to reach the American Association of Poison Control Centers or use its online resource if you think you’ve used too much ondansetron. But if you have severe symptoms, call 911 (or your local emergency number) immediately or go to the nearest emergency room.


If you think it is an emergency, call 999 or find your nearest A&E
If you need help now, but it’s not an emergency go to 111.nhs.uk or call 111. Alternatively you can speak to one of our pharmacists or use the Now Patient app to make an appointment with your GP.

What should I do if I miss my dose?

There are occasions when people forget to take their medication at correct prescribed times. This may not only have an effect on potentially making the medication less effective but it may also inadvertently lead to taking doses too close together, thereby increasing the risks of side effects.

Click here to find out what to do if you forgot to take your medication

What is generic ondansetron?

Generic ondansetron refers to the non-brand-name version of the medication. It contains the same active ingredient as the brand-name drug but is typically less expensive.

FDA approval of ondansetron

Ondansetron is approved by the U.S. Food and Drug Administration (FDA) for the prevention of nausea and vomiting caused by chemotherapy, radiation therapy, and surgery.

Active ingredient of ondansetron

The active ingredient of ondansetron is ondansetron hydrochloride.

US brand name of ondansetron and manufacturer

Ondansetron (dan-se-tron) is available in the US under various brand names, including Zofran, Zofran ODT, and Zuplenz. It is manufactured by various pharmaceutical companies.

UK brand name of ondansetron and manufacturer

In the UK, ondansetron is available under various brand names, including Zofran. The manufacturer may vary depending on the brand name.

Prescription requirement for ondansetron

A prescription (Rx) is required for ondansetron in both the US and the UK.

Availability of ondansetron in the UK with NHS prescription

Ondansetron is available in the UK with an NHS prescription.

Conditions treated by ondansetron

Ondansetron is an antiemetic primarily used for the prevention and treatment of nausea and vomiting associated with chemotherapy, radiation therapy, and surgery. It is also used off-label for the treatment of other types of nausea and vomiting.

How does ondansetron work?

Ondansetron belongs to a class of medications called serotonin 5-HT3 receptor antagonists. It works by blocking the action of serotonin, a neurotransmitter, in the brain and gastrointestinal tract. By inhibiting the activity of serotonin, ondansetron helps prevent nausea and vomiting. It is metabolised by hepatic cytochrome P-450 enzymes.

Forms of ondansetron available

Ondansetron is available in various forms, including oral tablets, orally disintegrating tablets, oral solution, and intramuscular or intravenous injection.

Dosage of ondansetron

The dose of ondansetron may vary depending on the specific condition being treated, the patient’s age and weight, and other individual factors. It is important to follow the prescribed dosage instructions provided by a healthcare professional.

Directions for ondansetron use

Take ondansetron as directed by the healthcare provider. The first dose is usually taken before chemotherapy, radiation therapy, or surgery to prevent nausea and vomiting. The tablets should be swallowed whole with water, while the orally disintegrating tablets can be placed on the tongue to dissolve.

Warnings and precautions for ondansetron

  • Ondansetron should be used with caution in individuals with certain medical conditions, such as liver disease or heart rhythm disorders. Dose adjustments may be necessary
  • Ondansetron may increase serotonin levels in the body and cause a serious condition known as serotonin syndrome
  • Tell your doctor if you have heart failure, a slow heartbeat, QT prolongation, or or if you have low magnesium or potassium blood levels, before using ondansetron
  • Tell your doctor if you have phenylketonuria, as ondansetron orally disintegrating tablets may contain phenylalanine

Use of ondansetron during pregnancy

The use of ondansetron during pregnancy should be carefully considered, and the potential risks and benefits should be discussed with a healthcare provider.

Use of ondansetron while breastfeeding

Ondansetron may pass into breast milk but is generally considered safe to use while breastfeeding. It is recommended to consult a healthcare provider before using ondansetron while breastfeeding.

Possible side effects of ondansetron

In clinical trials common side effects of ondansetron may include headache, constipation, dizziness, drowsiness, and fatigue. Serious side effects such as blurred vision and allergic reactions are rare. Get medical help immediately if you have symptoms such as a rash, swelling of the face, tongue, or throat, chest pain, or trouble breathing.

Interactions with other drugs

Ondansetron may interact with certain medications, including apomorphine, carbamazepine, phenytoin, medications for irregular heart beat, selective serotonin reuptake inhibitors, and tramadol.

It is important to inform your healthcare provider about all the medications you are taking, including prescription drugs, over-the-counter (OTC) drugs, dietary supplements, multivitamins, and herbal products, to avoid any adverse effects and potential drug interactions.

Similar drugs to ondansetron

Other medications used for the prevention of nausea and vomiting include granisetron, dolasetron, and palonosetron.



Now Patient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information in this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

Stefano Mirabello Medical Reviewer
Pharmacist / B.Pharm
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