ZOFRAN
Are you tired of high medication costs? Our service offers unbeatable savings on your ZOFRAN prescription medication. We provide a range of solutions to help you save up to 100% on your medication costs*. Whether you are insured, uninsured, underinsured, or simply looking to reduce your out-of-pocket expenses, we've got you covered.
Manufactured by GlaxoSmithKline
*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.
This content is intended for US audiences only
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ZOFRAN key facts
What is ZOFRAN?
ZOFRAN is the brand name for ondansetron and is available as an oral tablet, oral solution, orally disintegrating tablet, and injection.
What dosages is ZOFRAN available in?
ZOFRAN is available as a 4mg/5 ml oral solution, a 4 mg and 8 mg orally disintegrating tablet, a 4 mg/2 ml injection, and a 4 mg, 8 mg, and 24 mg oral tablet.
What is ZOFRAN used for?
ZOFRAN is an antiemetic and is used for the:
- Prevention of nausea and vomiting due to cancer medications (chemotherapy) or radiation therapy
- Prevention of nausea and vomiting after surgery
How does ZOFRAN work?
ZOFRAN is an antiemetic medication. It works by blocking the actions of serotonin in the part of your brain that causes nausea and vomiting. This helps you feel less nauseous and less of an urge to vomit.
How do I take ZOFRAN?
ZOFRAN is dosed as follows:
Adults
- Prevention of nausea and vomiting from chemotherapy: Your oncologist will determine your dose based on how likely it is for your chemotherapy medications to cause nausea and vomiting
- High-risk chemotherapy: The typical dose is 24 mg as a single dose, taken by mouth 30 minutes before the start of chemotherapy
- Medium-risk chemotherapy: The typical dose is 8 mg as a single dose, taken by mouth 30 minutes before the start of chemotherapy. Take another 8 mg dose by mouth 8 hours after the first dose. After that, take an 8 mg dose by mouth every 12 hours for 1 to 2 days after completing chemotherapy
- Prevention of nausea and vomiting from radiation therapy: The typical dose is 8 mg as a single dose, taken by mouth 1 to 2 hours before radiation therapy
- Depending on the type and location of radiation therapy, you might need to take additional 8 mg doses by mouth every 8 hours for 1 to 2 days after completing radiation
- Prevention of nausea and vomiting after surgery: The typical dose is 16 mg as a single dose, taken by mouth 1 hour before receiving anesthesia
Children (age 12 to under 18)
- Prevention of nausea and vomiting from chemotherapy: The typical dose is 8 mg as a single dose, taken by mouth 30 minutes before the start of chemotherapy. Take another 8 mg dose by mouth 8 hours after the first dose. After that, take 8 mg by mouth every 12 hours for 1 to 2 days after completing chemotherapy
Children (age 4 to under 12)
- Prevention of nausea and vomiting from chemotherapy: The typical dose is 4 mg as a single dose, taken by mouth 30 minutes before the start of chemotherapy. Take another 4 mg dose by mouth 4 hours and 8 hours after the first dose. After that, take 4 mg by mouth every 8 hours for 1 to 2 days after completing chemotherapy
ZOFRAN is also available as an injection through the veins (IV) or into the muscle (IM) administered by a healthcare professional (HCP) for certain situations.
Is it safe for me to take ZOFRAN?
ZOFRAN is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you are also taking apomorphine (Apokyn) due to risk of severely low blood pressure and loss of consciousness.
ZOFRAN Common Side Effects
Common side effects of ZOFRAN:
- Headache
- Fatigue
- Constipation
- Diarrhea
ZOFRAN Serious Side Effects
Serious side effects are rare with ZOFRAN. Contact your healthcare provider immediately if you experience any of the following.
- Serious allergic reactions: hives; trouble breathing; swelling of your face, lips, tongue, or throat
- Abnormal heart rhythm: chest pounding, irregular heart beat, chest pain, short of breath, feeling faint or lightheaded
- Heart attack
- Serotonin syndrome: fast heart rate, dizziness, sweating, flushing, tremor (shakiness), muscle stiffness or twitching, uncoordinated movement, distress, hallucinations
Effects of other drugs, drug classes and over-the-counter products on ZOFRAN
The following medications may interact with ZOFRAN:
- Serotonergic Drugs: Serotonin syndrome (including altered mental status, autonomic instability, and neuromuscular symptoms) has been described following the concomitant use of 5-HT3 receptor antagonists and other serotonergic drugs including selective serotonin reuptake inhibitors (SSRIs) and serotonin and noradrenaline reuptake inhibitors (SNRIs)
- Drugs Affecting Cytochrome P-450 Enzymes: In patients treated with potent inducers of CYP3A4 (i.e., phenytoin, carbamazepine, and rifampin), the clearance of ondansetron was significantly increased and ondansetron blood concentrations were decreased. However, on the basis of available data, no dosage adjustment for ZOFRAN is recommended for patients on these drugs.
Who makes ZOFRAN?
GlaxoSmithKline
Is ZOFRAN safe in pregnancy?
It is not known if ZOFRAN will harm your unborn baby. You and your doctor will have to decide if you should take ZOFRAN while you are pregnant or if you plan to become pregnant.
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effectsDrug Savings Guide
A practical guide to saving money and receiving support with prescription costs
How can NowPatient help me to lower the cost of my ZOFRAN prescription?
After you create a FREE account with NowPatient, you will have access to 4 programs that can help lower the cost of your ZOFRAN prescription
Applicability to each program will be dependent on your insurance status.
How do the NowPatient ZOFRAN savings programs work?
After you have created your FREE account with NowPatient, you can access the various programs from your account dashboard. Each program has clear instructions on how to check your eligibility. You can see how the process works by clicking on the feature link below and seeing the ‘How it works’ steps.
Drug Coupon and Patient Assistance Programs require an eligibility quiz to be completed.
Are the NowPatient ZOFRAN savings programs suitable for everyone, regardless of insurance status?
No. Each program has its own eligibility and applicability requirements. The table below shows if a program is available to you, based on your insurance status.
| Rx Advantage Card* for ZOFRAN | Canadian Prescription Savings* for ZOFRAN | ZOFRAN Drug Coupon* | ZOFRAN Patient Assistance Program* | |
| Insured (federal, state or government) | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured (Commercial or Private) | Available | Available | Available If Offered by Pharmaceutical Company | Available If Offered by Pharmaceutical Company |
| Uninsured | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured but without pharmacy benefit or drug coverage | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
*This is not insurance.
Are the NowPatient drug savings programs suitable for brand and generic versions of ZOFRAN?
No. Each program has applicability requirements. Please see below
| Rx Advantage Card* for ZOFRAN | Canadian Prescription Savings* for ZOFRAN | ZOFRAN Drug Coupon* | ZOFRAN Patient Assistance Program* | |
| Brand | Yes | Yes | Yes, If Offered by Pharmaceutical Company | Yes, If Offered by Pharmaceutical Company |
| Generic | Yes | Yes | No | No |
*This is not insurance.
If you have Medicare Part D or Medicare Advantage and none of the ZOFRAN savings options are applicable or affordable for me, what can you do?
If you are insured with Medicare and the ZOFRAN drug savings options are not applicable to you and still remain unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and after you have selected your state, it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
People who qualify for both Medicare and Medicaid are called ‘dual eligibles’.
If you are denied Medicaid for ZOFRAN, and you are still unable to afford your copay or co-insurance element (for example if you are in the coverage gap or Donut Hole) then you may be eligible for a federal support program like Low Income Subsidy. To be eligible for Low Income Subsidy, you need to be a resident in one of the 50 States or the District of Columbia. You can check eligibility online at SSA Medicare D Extra Help. You can also call Social Security at 1-800-772-1213 (TTY 1-800-325-0778).
I am uninsured or underinsured and none of the ZOFRAN prescription saving options are applicable or affordable for me, what can I do?
If you are uninsured or underinsured (for example, ZOFRAN is not covered by your plan) and the drug savings options are not applicable or still unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
If you are denied and all else fails, and if you have been prescribed ZOFRAN for an FDA-approved indication, you can call the pharmaceutical company to see if they have any other assistance programs.
I am commercially or privately insured and none of the ZOFRAN prescription saving options are applicable or affordable for me, what can I do?
If your medication is not covered by your plan, you can you can appeal your insurance company’s decision. Sometimes, a formal appeal can result in the drug being covered if it is deemed medically necessary.
If you cannot afford your copay, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
However, being privately insured might complicate your eligibility for Medicaid, as having private insurance may be considered in the financial eligibility assessment.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. If you qualify, state Medicaid may cover the full cost of your medication.
If I have federal, state or commercial insurance and none of the ZOFRAN prescription saving options are applicable or affordable for me, are there any other support organisations that can help me with my co-insurance or copay?
If you have already tried Medicaid and received a denial letter or if you are insured with Medicare and have been denied Low-Income Subsidy, then you can try one of the following organizational support programs:
1. Patient Access Network Foundation (PAN) assistance for ZOFRAN
If you are having trouble paying for your ZOFRAN medication due to unaffordable copays or deductibles, the Patient Access Network Foundation (PAN), may be able to assist you. To qualify for PAN assistance for ZOFRAN you will need to meet one or all of the following criteria:
- Your income is below 400% of the federal poverty level
- ZOFRAN is prescribed for an approved FDA indication
- You live in and receive treatment in the United States or U.S. territories, even if you do not have U.S. citizenship
- You have Medicare insurance coverage that covers ZOFRAN
- If ZOFRAN is listed on PAN’s list of covered medications
You can check the Patient Access Network Foundation Website for more information.
2. HealthWell Foundation Copay Program for ZOFRAN
If you are having trouble paying for your ZOFRAN medication due to unaffordable copays or deductibles, the HealthWell Foundation Copay Program may be able to assist you. To qualify for assistance for ZOFRAN you will need to meet the following criteria:
- You live in and are being treated in the United States
- You are insured and your plan covers ZOFRAN
- If ZOFRAN is listed on the HealthWell Foundation’s list of covered medications
You can check the HealthWell Foundation Website for more information.
3. Patient Advocate Foundation Co-Pay Relief Program for ZOFRAN
Patient Advocate Foundation’s Co-Pay Relief program exists to help reduce the financial distress you or your family may face when paying for your ZOFRAN treatment. If you qualify and can demonstrate the need, the foundation will provide you with direct payment covering co-pays, co-insurance, and deductibles. To qualify for assistance for ZOFRAN you will need to meet the following criteria:
- You must be currently insured and have coverage for ZOFRAN
- You must have a confirmed diagnosis and treatment plan
- You must reside and receive treatment in the United States
- Your Income must fall at or below 300% or 400% of the Federal Poverty Guideline (FPG) with consideration for the Cost of Living Index (COLI) and number in the household
- Applications can also be completed by contacting the program sponsor, toll-free at 866-512-3861.
You can check the Patient Advocate Foundation Website for more information.
Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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