ZOFRAN ODT
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Manufactured by GlaxoSmithKline
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ZOFRAN ODT Uses, Side Effects, Interactions, Warnings & Dosing
What is ZOFRAN ODT?
ZOFRAN ODT is the brand name for ondansetron and is available as an orally disintegrating tablet.
What dosages is ZOFRAN ODT available in?
ZOFRAN ODT is available as a 4 mg and 8 mg orally disintegrating tablet.
What is ZOFRAN ODT used for?
ZOFRAN ODT is an antiemetic and is used for the:
Prevention of nausea and vomiting due to cancer medications (chemotherapy) or radiation therapy
Prevention of nausea and vomiting after surgery
How does ZOFRAN ODT work?
ZOFRAN ODT is an antiemetic medication. It works by blocking the actions of serotonin in the part of your brain that causes nausea and vomiting. This helps you feel less nauseous and less of an urge to vomit.
How do I take ZOFRAN ODT?
ZOFRAN ODT is dosed as follows:
Adults
Prevention of nausea and vomiting from chemotherapy: Your oncologist will determine your dose based on how likely it is for your chemotherapy medications to cause nausea and vomiting.
High-risk chemotherapy: The typical dose is 24 mg as a single dose, taken by mouth 30 minutes before the start of chemotherapy.
Medium-risk chemotherapy: The typical dose is 8 mg as a single dose, taken by mouth 30 minutes before the start of chemotherapy. Take another 8 mg dose by mouth 8 hours after the first dose. After that, take an 8 mg dose by mouth every 12 hours for 1 to 2 days after completing chemotherapy.
Prevention of nausea and vomiting from radiation therapy: The typical dose is 8 mg as a single dose, taken by mouth 1 to 2 hours before radiation therapy. Depending on the type and location of radiation therapy, you might need to take additional 8 mg doses by mouth every 8 hours for 1 to 2 days after completing radiation.
Prevention of nausea and vomiting after surgery: The typical dose is 16 mg as a single dose, taken by mouth 1 hour before receiving anesthesia.
Children (age 12 to under 18)
Prevention of nausea and vomiting from chemotherapy: The typical dose is 8 mg as a single dose, taken by mouth 30 minutes before the start of chemotherapy. Take another 8 mg dose by mouth 8 hours after the first dose. After that, take 8 mg by mouth every 12 hours for 1 to 2 days after completing chemotherapy.
Children (age 4 to under 12)
Prevention of nausea and vomiting from chemotherapy: The typical dose is 4 mg as a single dose, taken by mouth 30 minutes before the start of chemotherapy. Take another 4 mg dose by mouth 4 hours and 8 hours after the first dose. After that, take 4 mg by mouth every 8 hours for 1 to 2 days after completing chemotherapy.
ZOFRAN is also available as an injection through the veins (IV) or into the muscle (IM) administered by a healthcare professional (HCP) for certain situations.
Is it safe for me to take ZOFRAN ODT?
ZOFRAN ODT is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you are also taking apomorphine (Apokyn) due to risk of severely low blood pressure and loss of consciousness.
ZOFRAN ODT Common Side Effects
Common side effects of ZOFRAN ODT:
- Headache
- Fatigue
- Constipation
- Diarrhea
ZOFRAN ODT Serious Side Effects
Serious side effects are rare with ZOFRAN ODT. Contact your healthcare provider immediately if you experience any of the following.
- Serious allergic reactions: hives; trouble breathing; swelling of your face, lips, tongue, or throat
- Abnormal heart rhythm: chest pounding, irregular heart beat, chest pain, short of breath, feeling faint or lightheaded
- Heart attack
- Serotonin syndrome: fast heart rate, dizziness, sweating, flushing, tremor (shakiness), muscle stiffness or twitching, uncoordinated movement, distress, hallucinations
Effects of other drugs, drug classes and over-the-counter products on ZOFRAN ODT
The following medications may interact with ZOFRAN ODT:
- Serotonergic Drugs: Serotonin syndrome (including altered mental status, autonomic instability, and neuromuscular symptoms) has been described following the concomitant use of 5-HT3 receptor antagonists and other serotonergic drugs including selective serotonin reuptake inhibitors (SSRIs) and serotonin and noradrenaline reuptake inhibitors (SNRIs)
- Drugs Affecting Cytochrome P-450 Enzymes: In patients treated with potent inducers of CYP3A4 (i.e., phenytoin, carbamazepine, and rifampin), the clearance of ondansetron was significantly increased and ondansetron blood concentrations were decreased However, on the basis of available data, no dosage adjustment for ZOFRAN ODT is recommended for patients on these drugs
Who makes ZOFRAN ODT?
GlaxoSmithKline
Is ZOFRAN ODT safe in pregnancy?
It is not known if ZOFRAN ODT will harm your unborn baby. You and your doctor will have to decide if you should take ZOFRAN ODT while you are pregnant or if you plan to become pregnant.
What to do if you missed your ZOFRAN ODT dose
The FDA's medical product safety reporting program for health professionals, patients and consumers.
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Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
Things to know
What does ODT mean for Zofran?
Will Zofran make you sleepy?
How often can you take Zofran 4 mg ODT?
How often is it OK to take Zofran?
Does Zofran stop vomiting?
How good is Zofran for nausea?
Why can Zofran be over the counter?
Is there a difference between Zofran and ondansetron?
Is ondansetron 4mg a narcotic?
Can you swallow an ODT Zofran?
What happens if you swallow ODT pill?
Will a dissolvable pill still work if you swallow it?
Can I drink water after taking ODT Zofran?
How long do you have to wait to eat after taking Zofran?
What does ODT mean on a prescription?
Can you take 2 Zofran at a time?
What does dissolving Zofran taste like?
What is the difference between ondansetron and Zofran?
How long does it take Zofran ODT to work?
Can you still throw up after taking Zofran?
Does ondansetron ODT make you sleepy?
Does dissolvable Zofran work better?
Do I let Zofran dissolve under my tongue?
Is ODT better than oral Zofran?
Can I drink water after dissolving Zofran?
When should you not use Zofran?
Why does Zofran make you feel good?
How often can you take Zofran 4 mg dissolvable?
Will Zofran stop a stomach virus?
Does Zofran help with anxiety?
What happens if you swallow an ODT tablet?
Why do you have to push Zofran slowly?
Does Zofran make you sleepy?
How long does it take for Zofran to wear off?
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