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Indomethacin is available as a 25 mg and 50 mg oral capsule as well as a 50 mg suppository.

Indomethacin is a NSAID and is used to treat moderate-to-severe rheumatoid arthritis, including flare-ups, moderate-to-severe ankylosing spondylitis, moderate-to-severe osteoarthritis, shoulder pain caused by bursitis or tendonitis, and gouty arthritis.

Indomethacin is a nonsteroidal anti-inflammatory drug, or better known as an NSAID. It works by blocking proteins in the body called cyclooxygenase (COX) that cause inflammation, swelling, and pain. This helps lessen inflammation, swelling, and pain from your condition.

Indomethacin is typically dosed as 50 mg to 200 mg by mouth per day, split up into 2 or 4 doses throughout the day.

Indomethacin is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs or for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery.

Common side effects of Indomethacin include:

• Headache
• Dizziness
• Nausea
• Stomach upset

Serious side effects are rare with Indomethacin. Contact your healthcare provider immediately if you experience any of the following.

• Stomach bleeding: feeling faint, vomiting blood, bloody or dark stools, severe stomach pain or discomfort
• Heart attack: chest pain or tightness; pain that radiates up to your shoulder, arm, neck, or jaw
• Heart failure: trouble breathing, swelling, fast heartbeat, sudden weight gain
• Stroke: sudden confusion, trouble breathing, weakness on one side of your body or face, slurred speech
• Worsening liver problems or liver failure: swelling of your stomach, yellowing of your skin or the whites of your eyes, confusion, dark or brown urine
• Serious kidney problems: tiredness, dry and itchy skin, low appetite, urinating less than usual, foamy or bloody urine, muscle cramps
• Allergic reactions: hives, rash, blisters, swelling of the lips or tongue, trouble breathing
  Serious skin reactions: skin reddening, skin peeling, blisters, rash

The following medications may interact with Indomethacin:

• ACE-Inhibitors and Angiotensin II Antagonists: Reports suggest that NSAIDs may diminish the antihypertensive effect of ACE-inhibitors and angiotensin II antagonists. Indomethacin can reduce the antihypertensive effects of captopril and losartan
• Aspirin: The use of Indomethacin in conjunction with aspirin or other salicylates is not recommended.
• Beta-adrenoceptor blocking agents: Blunting of the antihypertensive effect of beta-adrenoceptor blocking agents by non-steroidal antiinflammatory drugs including Indomethacin has been reported
• Cyclosporine: Administration of non-steroidal anti-inflammatory drugs concomitantly with cyclosporine has been associated with an increase in cyclosporine-induced toxicity
• Digoxin: Indomethacin given concomitantly with digoxin has been reported to increase the serum concentration and prolong the half-life of digoxin
• Probenecid: When Indomethacin is given to patients receiving probenecid, the plasma levels of Indomethacin are likely to be increased

Various FDA-approved generic manufacturers

It’s not completely clear whether Indomethacin is safe to take during the first 20 weeks of pregnancy. But you should avoid Indomethacin after 20 weeks of pregnancy because it might cause developmental problems in your unborn baby or complications during delivery.

• Indocin
• Indocin SR