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Indocin SR is the brand name for indomethacin and is available as an extended-release oral capsule.

Indocin SR is available as a 75 mg extended-release oral capsule.

Indocin SR is a NSAID and is used to treat moderate-to-severe rheumatoid arthritis, including flare-ups, moderate-to-severe ankylosing spondylitis, moderate-to-severe osteoarthritis, shoulder pain caused by bursitis or tendonitis, and gouty arthritis.

Indocin SR is a nonsteroidal anti-inflammatory drug, or better known as an NSAID. It works by blocking proteins in the body called cyclooxygenase (COX) that cause inflammation, swelling, and pain. This helps lessen inflammation, swelling, and pain from your condition.

Indocin SR is typically dosed as 75 mg by mouth once a day.

Indocin SR is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs or for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery.

Common side effects of Indocin SR include:

• Headache
• Dizziness
• Nausea
• Stomach upset

Serious side effects are rare with Indocin SR. Contact your healthcare provider immediately if you experience any of the following.

• Stomach bleeding: feeling faint, vomiting blood, bloody or dark stools, severe stomach pain or discomfort
• Heart attack: chest pain or tightness; pain that radiates up to your shoulder, arm, neck, or jaw
• Heart failure: trouble breathing, swelling, fast heartbeat, sudden weight gain
• Stroke: sudden confusion, trouble breathing, weakness on one side of your body or face, slurred speech
• Worsening liver problems or liver failure: swelling of your stomach, yellowing of your skin or the whites of your eyes, confusion, dark or brown urine
• Serious kidney problems: tiredness, dry and itchy skin, low appetite, urinating less than usual, foamy or bloody urine, muscle cramps
• Allergic reactions: hives, rash, blisters, swelling of the lips or tongue, trouble breathing
• Serious skin reactions: skin reddening, skin peeling, blisters, rash

The following medications may interact with Indocin SR:

• ACE-Inhibitors and Angiotensin II Antagonists: Reports suggest that NSAIDs may diminish the antihypertensive effect of ACE-inhibitors and angiotensin II antagonists. Indocin SR can reduce the antihypertensive effects of captopril and losartan
• Aspirin: The use of Indocin SR in conjunction with aspirin or other salicylates is not recommended
• Beta-adrenoceptor blocking agents: Blunting of the antihypertensive effect of beta-adrenoceptor blocking agents by non-steroidal antiinflammatory drugs including Indocin SR has been reported
• Cyclosporine: Administration of non-steroidal anti-inflammatory drugs concomitantly with cyclosporine has been associated with an increase in cyclosporine-induced toxicity
• Digoxin: Indocin SR given concomitantly with digoxin has been reported to increase the serum concentration and prolong the half-life of digoxin
• Probenecid: When Indocin SR is given to patients receiving probenecid, the plasma levels of indomethacin are likely to be increased

Merck & Co., Inc.

It’s not completely clear whether Indocin SR is safe to take during the first 20 weeks of pregnancy. But you should avoid INDOCIN SRafter 20 weeks of pregnancy because it might cause developmental problems in your unborn baby or complications during delivery.

• Indomethacin