cobimetinib
Used for Cancer
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Manufactured by various FDA-approved generic manufacturers.
*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.
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cobimetinib Uses, Side Effects, Interactions, Warnings & Dosing
What dosages is cobimetinib available in?
cobimetinib is available as a 20 mg oral tablet.
What is cobimetinib used for?
cobimetinib is a MEK inhibitor that is used to treat:
- Melanoma with certain BRAF mutations that has spread (metastatic) or can’t be removed by surgery, used together with Zelboraf (vemurafenib)
- Histiocytic neoplasms
How does cobimetinib work?
cobimetinib is a kinase inhibitor known as a MEK inhibitor. MEK is a protein in the body that’s important for cell growth. cobimetinib works by blocking the MEK protein. When the medication blocks MEK, cancer cells can’t grow and spread as well. For people with melanoma with a BRAF mutation, cobimetinib is taken with Zelboraf (vemurafenib). The BRAF protein also helps cells grow, and cells can grow too quickly when there’s a BRAF mutation. By blocking two different proteins, cobimetinib and vemurafenib (Zelboraf) work together to stop the growth and spread of cancer better.
How do I take cobimetinib?
The usual dose is 60 mg by mouth once a day for 3 weeks. Then, you’ll take 1 week off from the medication. This is considered one treatment cycle. Repeat the treatment cycle (3 weeks of treatment, followed by 1 week off) for as long as you’re taking the medication.
Is it safe for me to take cobimetinib?
cobimetinib is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.
cobimetinib Common Side Effects
Common side effects of cobimetinib:
- Higher creatinine levels in blood
- Higher liver enzymes in blood
- Higher creatine phosphokinase (CPK) levels in blood
- Other blood test abnormalities
- Diarrhea
- Skin that’s sensitive to the sun
- Nausea
- Fever
- Vomiting
cobimetinib Serious Side Effects
Serious side effects are rare with cobimetinib. Contact your healthcare provider immediately if you experience any of the following.
- Bleeding: blood in urine, blood in stool, vaginal bleeding, sudden and severe headache
- Serious eye problems: sudden and severe eye pain, sudden vision loss
- Serious muscle problems: severe muscle pain or stiffness, dark red or brown urine, sudden muscle weakness
Effects of other drugs, drug classes and over-the-counter products on cobimetinib
The following medications may interact with cobimetinib:
- Avoid concomitant administration of cobimetinib with strong or moderate CYP3A inducers or inhibitors
Who makes cobimetinib?
Various FDA-approved generic manufacturers
Is cobimetinib safe in pregnancy?
cobimetinib can harm your unborn baby. Females who are able to become pregnant should use effective birth control (contraception) during treatment with cobimetinib and for 2 weeks after the final dose of cobimetinib.
Talk to your healthcare provider about birth control methods that may be right for you. Tell your healthcare provider right away if you become pregnant or think you are pregnant during treatment with cobimetinib.
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effects
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Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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