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Cotellic is the brand name for cobimetinib oral tablets.

Cotellic is available as a 20 mg oral tablet.

Cotellic is a MEK inhibitor that is used to treat:

• Melanoma with certain BRAF mutations that has spread (metastatic) or can’t be removed by surgery, used together with Zelboraf (vemurafenib)
• Histiocytic neoplasms

Cotellic is a kinase inhibitor known as a MEK inhibitor. MEK is a protein in the body that’s important for cell growth. Cotellic works by blocking the MEK protein. When the medication blocks MEK, cancer cells can’t grow and spread as well. For people with melanoma with a BRAF mutation, Cotellic is taken with Zelboraf (vemurafenib). The BRAF protein also helps cells grow, and cells can grow too quickly when there’s a BRAF mutation. By blocking two different proteins, Cotellic and vemurafenib (Zelboraf) work together to stop the growth and spread of cancer better.

The usual dose is 60 mg by mouth once a day for 3 weeks. Then, you’ll take 1 week off from the medication. This is considered one treatment cycle. Repeat the treatment cycle (3 weeks of treatment, followed by 1 week off) for as long as you’re taking the medication.

Cotellic is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Cotellic:

• Higher creatinine levels in blood
• Higher liver enzymes in blood
• Higher creatine phosphokinase (CPK) levels in blood
• Other blood test abnormalities
• Diarrhea
• Skin that’s sensitive to the sun
• Nausea
• Fever
• Vomiting

Serious side effects are rare with Cotellic. Contact your healthcare provider immediately if you experience any of the following.

• Bleeding: blood in urine, blood in stool, vaginal bleeding, sudden and severe headache
• Serious eye problems: sudden and severe eye pain, sudden vision loss
• Serious muscle problems: severe muscle pain or stiffness, dark red or brown urine, sudden muscle weakness

The following medications may interact with Cotellic:

• Avoid concomitant administration of Cotellic with strong or moderate CYP3A inducers or inhibitors

Genentech, Inc.

Cotellic can harm your unborn baby. Females who are able to become pregnant should use effective birth control (contraception) during treatment with Cotellic and for 2 weeks after the final dose of Cotellic.
Talk to your healthcare provider about birth control methods that may be right for you. Tell your healthcare provider right away if you become pregnant or think you are pregnant during treatment with Cotellic.

• Cobimetinib