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MEDICAL INFORMATION
Fluconazole Key Facts
Other Related Names or Treatments
Canesten, Diflucan
About Fluconazole
Fluconazole is an azole antifungal used for the treatment of non-systemic Candida infections of the vagina (yeast infections), throat, and mouth. It is also used to prevent fungal infections in people with a weakened immune system caused by bone marrow transplant, cancer treatment, or AIDs.
NowPatient offers Diflucan or Fluconazole for the treatment of thrush only, following an online consultation with a prescribing clinician.
Key facts of Fluconazole
- For the treatment of vaginal candidiasis, thrush, oral thrush, esophageal candidiasis, other candida infections or fungal meningitis
- Fluconazole has some common side effects which include nausea and diaarhea
- It can be dangerous if you take Fluconazole with certain medications. If you’re not sure if it is safe, discuss this with the prescribing clinician
Who is Fluconazole not suitable for?
Fluconazole may not be suitable for some people. To make sure it’s safe for you, speak to the prescribing clinician before taking Fluconazole if you:
- Are allergic to Fluconazole or other antifungals such as itraconazole, ketoconazole, miconazole, or voriconazole
- Have kidney disease or liver disease
- Have high blood potassium levels
- Have heart problems
How and where to get Fluconazole?
You can buy Fluconazole safely and securely from NowPatient. You can start a consultation today for free and if you qualify for treatment, you only pay for the cost of the medication. Delivery is made to your home or office from our registered pharmacy.
Our service is certified, safe and effective, and we only ever treat conditions. If you book a consultation with a prescribing clinician for the treatment of thrush, you can discuss if Fluconazole is a suitable treatment option for you.
At the end of the consultation, the clinician will decide if a treatment plan is suitable for you. If it is, the clinician will issue you with a prescription which can then be ordered, paid for and delivered directly to your chosen address by NowPatient.
Dosage and strength for Fluconazole for thrush
Fluconazole is available as a 150 mg capsule or oral suspension when used for thrush.
Information about how to take Fluconazole for thrush
Thrush is often treated with only one pill. You may take Fluconazole with or without food. Speak to a healthcare professional or read the patient information leaflet provided with your medication if you need further information.
What happens if you take too much Fluconazole?
If you take more than prescribed, then it can lead to some unpleasant side effects. You should talk to your doctor or reach out to one of our prescribing clinicians, if you have taken too much Fluconazole and you experience any of the following side effects:
What are the side effects of Fluconazole?
Side effects of Fluconazole are split into common and serious.
Common side effects include:
- Nausea, diarrhea
- Stomach pain
- Headaches, dizziness
Serious side effects include:
- Increased heart rate, shortness of breath, feeling faint
- Seizures
- Reduced adrenal gland hormones – stomach pain, loss of appetite, muscle or joint pain, nausea, vomiting
- Skin rash
- Liver problems – loss of appetite, abdominal pain, tiredness, dark urine, jaundice (yellowing of the skin or eyes)
If you experience any serious life-threatening side effects, you should contact NHS 111.
If you experience a serious allergic reaction with the signs shown below you should contact emergency services on 999.
- Your lips, mouth, throat or tongue suddenly become swollen
- You’re breathing very fast or struggling to breathe (you may become very wheezy or feel like you’re choking or gasping for air)
- Your throat feels tight or you’re struggling to swallow
- Your skin, tongue or lips turn blue, grey or pale (if you have black or brown skin, this may be easier to see on the palms of your hands or soles of your feet)
- You suddenly become very confused, drowsy or dizzy
- Someone faints and cannot be woken up
Always report adverse effects to the MHRA yellow card reporting system. You can read more about this here How and where do I report side effects of my medication? – NowPatient
Information about taking Fluconazole at the same time as other medications or herbal supplements
There is not enough evidence to suggest there are any drug interactions between herbal supplements and Fluconazole. In any event, you should let your prescribing clinician know if you are taking any herbal supplements or other prescription drugs:
- Cisapride, pimozide, tofacitinib, tolvaptan
- Vitamin A supplement
- Erythromycin
- Quinidine
- Terfenadine
- Alfentanil, fentanyl, methadone
- Theophylline
- Warfarin
- Atorvastatin, simvastatin
- Glyburide, glipizide
- Blood pressure medication
- Tacrolimus, sirolimus
- Carbamazepine, phenytoin
Can Fluconazole taken for thrush be taken long term?
Fluconazole is taken as a single dose when used to treat thrush. If your symptoms do not clear, speak to your doctor for further advice.
Is there a herbal Fluconazole?
No. Herbal Fluconazole does not exist. If you have been marketed such a formulation, it may be fake.
Can women use Fluconazole?
Women can take Fluconazole for the treatment of thrush. However, Fluconazole may pass into breast milk. Consult your doctor before breast-feeding.
Should I avoid any particular food or drink when taking Fluconazole?
You can eat and drink normally when taking Fluconazole.
What lifestyle changes can I make to help me with thrush?
Certain foods such as yoghurts containing live cultures (acidophilus and lactobacilli) help prevent yeast overgrowth. Also, maintaining good personal hygeine will help to reduce the risk of fungal infections.
Alternatives to Fluconazole
Alternatives for the treatment of thrush include Diflucan, Canesten creams and Canesten pessaries.
Sources
- NHS Fluconazole
- Mayoclinic – Fluconazole
Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
Related Articles
FAQs
Answers to Popular Questions About Fluconazole
What is Fluconazole?
Fluconazole is a triazole antifungal medication widely used to treat fungal infections. It is the active ingredient in Diflucan and is available as generic capsules (50 mg, 150 mg, 200 mg), oral suspension, and intravenous infusion. The 150 mg single capsule is one of the most commonly purchased over-the-counter medications for vaginal thrush in the UK. Fluconazole is also used for systemic and serious fungal infections at higher doses. It is available both OTC and on prescription.
What is Fluconazole used for?
Fluconazole is used for vaginal thrush (candidal vulvovaginitis — single 150 mg dose), oral thrush (oropharyngeal candidiasis), candidal balanitis (thrush in men), oesophageal candidiasis, systemic candidiasis, cryptococcal meningitis, dermatomycosis (skin fungal infections when topical treatment is inadequate), and prophylaxis of fungal infections in immunocompromised patients. The versatility of fluconazole makes it one of the most commonly prescribed antifungals worldwide.
How does Fluconazole work?
Fluconazole inhibits the fungal cytochrome P450 enzyme lanosterol 14α-demethylase, blocking the conversion of lanosterol to ergosterol. Ergosterol is essential for fungal cell membrane integrity. Depletion of ergosterol causes increased cell membrane permeability and disruption of cell function, ultimately leading to cell death. Fluconazole has excellent oral bioavailability (>90%) and penetrates well into cerebrospinal fluid, vaginal secretions, saliva, and skin, making it effective across many sites of infection.
How do I take Fluconazole for thrush?
For vaginal thrush: take a single 150 mg capsule with water at any time, with or without food. Most women experience symptom relief within 24–48 hours. For oral thrush: 50–100 mg once daily for 7–14 days. For candidal balanitis in men: a single 150 mg dose. For recurrent vaginal thrush (4+ episodes per year): your doctor may prescribe a regimen of 150 mg every 72 hours for 3 doses as induction, followed by 150 mg once weekly for up to 6 months as maintenance.
How quickly does Fluconazole work?
For vaginal thrush, symptom improvement is often noticeable within 12–24 hours, with complete resolution typically within 1–3 days. The single 150 mg capsule continues working for several days after taking it due to fluconazole’s long half-life (approximately 30 hours). If symptoms do not improve within 7 days, or recur within 2 months, see your doctor as the infection may not be caused by Candida or may be a resistant strain.
What are the side effects of Fluconazole?
The single-dose 150 mg treatment for thrush is generally very well-tolerated. Common side effects include headache, nausea, abdominal pain, and diarrhoea. At higher doses or with prolonged use, liver toxicity can occur — seek medical advice for jaundice, dark urine, or unexplained fatigue. Rash is uncommon; severe skin reactions are very rare. QT prolongation is possible at higher doses.
Can I take Fluconazole during pregnancy?
No, oral fluconazole should be avoided during pregnancy. MHRA safety advice warns that high-dose fluconazole has been associated with congenital abnormalities. Even the single 150 mg thrush dose is not recommended during pregnancy. Use topical clotrimazole (pessary/cream) instead for vaginal thrush in pregnancy. If you discover you are pregnant after taking fluconazole, the risk from a single 150 mg dose is considered very low, but inform your midwife.
Does Fluconazole affect condoms?
No, oral fluconazole capsules do not affect condoms or diaphragms. This is an advantage over topical clotrimazole pessaries and creams, which can weaken latex. However, you may want to wait until thrush symptoms have cleared before resuming sexual intercourse for comfort.
How can I get Fluconazole?
Fluconazole 150 mg (single capsule) is available OTC from pharmacies for women aged 16–60 with a previous thrush diagnosis. For men, recurrent thrush, or other indications, a prescription from your GP or online service like NowPatient is required.
Experienced a Side Effect?
Report to Yellow Card (UK) or MedWatch (US)
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