ZonisamidePrices, Coupons & Savings

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*Based on the difference between the U&C price submitted and the price the patient paid, as of April 2023.

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  2. Zonisamide
    Generic for Zonegran
    30 capsules $5.1 USD
    Save $15.90
  3. Zonisamide
    Generic for Zonegran
    30 capsules $4.2 USD
    Save $16.80
  4. Zonisamide
    Generic for Zonegran
    30 capsules $4.5 USD
    Save $16.50
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Do you need a prescription for zonisamide?

Yes, zonisamide is only available with a valid physician Rx.

How much is zonisamide without Insurance in the US?

Our website gives two competitive savings options to US customers who wish to purchase zonisamide, as either a brand or generic, if available. The first is access to medications through our mail-order online pharmacy. The second is by using the Now Patient Rx Advantage Card, which can be used in over 65,000 pharmacies nationwide, across America. If you are insured, then in most cases, the cash price will be significantly cheaper than the copay.

What will my out-of-pocket cost be for zonisamide in the US?

There are no out-of-pocket (OOP) costs because we are currently only offering a cash-based option to purchase medications.

Is Now Patient a zonisamide savings card?

Yes. Save up to 90% on your zonisamide with the FREE Now Patient Rx Advantage card*.
*Based on the difference between the U&C submitted by the pharmacy and the price the patients pay.

Can you handle Rx transfers for home delivery in the US?

Yes. If you use the mail-order online pharmacy option, then we can handle requests by you to have your prescription transferred to our pharmacy for home delivery. We can even help you manage your refills by giving you timely reminders, so you do not run out of your medication.

Is Now Patient a zonisamide coupon provider in the US?

No. Now Patient does not provide zonisamide coupons or FREE zonisamide samples.

Do you accept commercial, Medicare or Medicaid coverage for zonisamide in the US?

No. Currently, we only offer cash-based options for purchase, therefore we do not require your insurance benefit details. In the future, our plan is to be able to handle commercial insurance, Medicare and Medicaid including cases where you have multiple health plans that provide benefit coverage (e.g. Medicaid and Commercial). We also anticipate being able to handle more complex scenarios such as using primary insurance combined with a manufacturer copay assistance program.

Does Now Patient work with Medicare?

Our cash-based prices for medications are typically cheaper than Medicare copays. We do not bill Medicare Part D (standalone drug coverage) or Medicare Advantage (combined health and drug coverage). When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

Does Now Patient work with Commercial Insurance?

Our cash-based prices for medications are typically cheaper than commercial plan copays. We do not bill your commercial plan. When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

What should you do if you use too much zonisamide?


Call your doctor right away or seek immediate medical attention if your symptoms do not improve or they become worse after using zonisamide. You can also call 800-222-1222 to reach the American Association of Poison Control Centers or use its online resource if you think you’ve used too much zonisamide. But if you have severe symptoms, call 911 (or your local emergency number) immediately or go to the nearest emergency room.


If you think it is an emergency, call 999 or find your nearest A&E
If you need help now, but it’s not an emergency go to 111.nhs.uk or call 111. Alternatively you can speak to one of our pharmacists or use the Now Patient app to make an appointment with your GP.

What should I do if I miss my dose?

There are occasions when people forget to take their medication at correct prescribed times. This may not only have an effect on potentially making the medication less effective but it may also inadvertently lead to taking doses too close together, thereby increasing the risks of side effects.

Click here to find out what to do if you forgot to take your medication

What is generic zonisamide?

Generic zonisamide refers to the non-brand-name version of the medication. It contains the same active ingredient as the brand-name drug but is typically less expensive.

FDA approval of zonisamide

Zonisamide is approved by the U.S. Food and Drug Administration (FDA) for the treatment of seizures in patients with epilepsy.

Active ingredient of zonisamide

The active ingredient of zonisamide is zonisamide.

US brand name of zonisamide and manufacturer

Zonisamide is a sulfonamide available in the US under the brand name Zonisade and Zonegran. It is manufactured by various manufacturers.

UK brand name of zonisamide and manufacturer

In the UK, zonisamide is available under the brand name Zonegran. The manufacturer may vary depending on the brand name.

Prescription requirement for zonisamide

A prescription (Rx) is required for zonisamide in both the US and the UK.

Availability of zonisamide in the UK with NHS prescription

Zonisamide is available in the UK with an NHS prescription.

Conditions treated by zonisamide

Zonisamide is an anticonvulsant drug primarily used for the treatment of seizures in patients with epilepsy. It may be prescribed as an adjunctive therapy to other antiepileptic medications.

How does zonisamide work?

The exact mechanism of action of zonisamide is not fully understood. It is believed to work by stabilizing the electrical activity in the brain and reducing the excessive firing of neurons, thus helping to prevent seizures.

Forms of zonisamide available

Zonisamide is available in the form of oral capsules and tablets.

Dosage of zonisamide

The dose of zonisamide may vary depending on the specific type of seizures being treated, the patient’s age and weight, and other individual factors. It is important to follow the medication guide provided by the healthcare provider.

Directions for zonisamide use

Zonisamide should be taken exactly as directed by the healthcare provider. The medication is usually taken once or twice daily with or without food. It is important to swallow the capsules or tablets whole and not crush or chew them.

Warnings and precautions for zonisamide

  • Zonisamide should be used with caution in individuals with certain medical conditions, such as kidney problems or liver disease. Dose adjustments may be necessary
  • It may interact with certain medications, including other antiepileptic drugs. Inform the healthcare provider about all medications being taken
  • This drug may cause metabolic acidosis. If left untreated this may increase the risk of kidney stones and bone problems
  • You may experience suicidal thoughts and behaviour, depression, or other mental health problems

Use of zonisamide during pregnancy

The use of zonisamide during pregnancy should be carefully considered, and the potential risks and benefits should be discussed with a healthcare provider.

Use of zonisamide while breastfeeding

Zonisamide is excreted in breast milk but is generally considered safe to use while breastfeeding. It is recommended to consult a healthcare provider before using zonisamide while breastfeeding.

Possible side effects of zonisamide

Common side effects of zonisamide may include dizziness, somnolence, constipation, weight loss, drowsiness, sleepiness, tiredness, loss of appetite, and difficulty concentrating. Serious side effects such as aplastic anemia, agranulocytosis, and irregular heartbeat are rare but can occur. Promptly report any concerning symptoms to a healthcare provider. Get medical help right away if you have a serious side effects such as an allergic reaction. Symptoms include hives, trouble breathing, worsening shortness of breath, sore throat, chest pain, swelling of the face, tongue or throat, skin rash, blisters, and serious skin reactions.

Interactions with other drugs

Ziprasidone may interact with certain medications, including antifungals such as itraconazole, carbonic anhydrase inhibitors such as acetazolamide, medications for Parkinson’s disease, other medications for seizures including carbamazepine, phenobarbital, and phenytoin, and hormonal contraceptives (birth control pills, patches, and rings). It is important to inform your healthcare provider about all the prescription drugs, over the counter nonprescription medications, salt substitutes, herbal products, supplements, and vitamins you are taking to avoid potential adverse effects and drug interactions.

Similar drugs to zonisamide

Other antiepileptic medications used for the treatment of seizures include lamotrigine, topiramate, and levetiracetam.


About Now Patient

Now Patient’s online services are available in the US and UK. We help you manage your prescriptions, doctor appointments, test results, health risks, and a lot more, all in one place for FREE. If you are in the United States, you could enjoy savings using Now Patient’s mail-order pharmacy or use the Now Patient Rx Advantage Card at over 65,000 pharmacies, with savings of up to 90% on popular FDA-approved brand and generic medications like Ozempic, Mounjaro, clopidogrel and lots more. We do not currently handle commercial insurance, Medicare or Medicaid. UK NHS and private prescriptions are delivered FREE of charge across England & Wales by our UK NHS online pharmacy.

Stefano Mirabello Medical Reviewer
Pharmacist / B.Pharm
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