Used for Epilepsy

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Programs are suitable for individuals who want to buy zonisamide without insurance, with insurance or for those who are underinsured. You can pay as little as $0 per fill.*

Manufactured by various FDA-approved generic manufacturers.

*Applicable to Drug Coupons & Patient Assistance Programs

This content is intended for US audiences only

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Updated on 24 Apr 2024

Learn more about zonisamide

What dosages is zonisamide available in?

What dosages is zonisamide available in?

zonisamide is available as 25 mg, 50 mg, and 100 mg capsule.

What is zonisamide used for?

What is zonisamide used for?

zonisamide is an antiepileptic that is used to treat partial-onset seizures.

How does zonisamide work?

How does zonisamide work?

zonisamide is an antiepileptic. This means it helps control seizures. It’s not exactly clear how zonisamide works, but it’s thought to block the nerves in your brain from sending electrical signals that cause seizures.

How do I take zonisamide?

How do I take zonisamide?

zonisamide is typically started at 100 mg by mouth daily (taken all at once or split into two doses throughout the day). Your provider might raise your dose every two weeks based on your response to the medication. The typical dosing range is from 100 mg to 600 mg by mouth daily.

Is it safe for me to take zonisamide?

Is it safe for me to take zonisamide?

zonisamide is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have an allergy to sulfonamides.

zonisamide Common Side Effects

zonisamide Common Side Effects

Common side effects of zonisamide:

  • Sleepiness
  • Dizziness
  • Loss of appetite
  • Headache
  • Nausea
  • Agitation or irritability
  • Fatigue
  • Tiredness
  • Depression
  • Problems with concentration or memory
  • Stomach pain
  • Double vision
zonisamide Serious Side Effects

zonisamide Serious Side Effects

Serious side effects are rare with zonisamide. Contact your healthcare provider immediately if you experience any of the following.

  • Serious skin reactions: blistering and peeling of the skin, fever, flu-like symptoms, trouble swallowing
  • Serious allergic reactions: swelling of the face and neck area, trouble breathing, rash, fever
  • Heat stroke: sweating less than usual, fever
  • Suicidal behavior: worsening depression, unusual changes in mood or behavior, suicidal thoughts
  • Kidney problems: sudden back pain, stomach pain, blood in the urine
  • Higher acid levels in blood: fast breathing, fast heartbeat, confusion, loss of appetite, nausea, weakness
Effects of other drugs, drug classes and over-the-counter products on zonisamide

Effects of other drugs, drug classes and over-the-counter products on zonisamide

The following medications may interact with zonisamide:

  • zonisamide should be used with caution if used in combination with alcohol or other CNS depressants
  • Concomitant use of zonisamide with any other carbonic anhydrase inhibitor may increase the severity of metabolic acidosis and may also increase the risk of kidney stone formation
Who makes zonisamide?

Who makes zonisamide?

Various FDA-approved generic manufacturers

Is zonisamide safe in pregnancy?

Is zonisamide safe in pregnancy?

zonisamide may cause harm to your unborn baby. Women of child bearing potential who are given zonisamide should be
advised to use effective contraception.


What to do if you missed your zonisamide dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

Learn more about reporting side effects
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Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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