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Ziac is the brand name for bisoprolol/hydrochlorothiazide and is available as an oral tablet.

Ziac is available as a 2.5 mg/6.25 mg, 5 mg/6.25 mg, and 10 mg/6.25 mg oral tablet.

Ziac is a beta-blocker and diuretic that is used to treat high blood pressure.

Ziac is a combination of two different medications that both work to lower blood pressure.
Bisoprolol is a cardioselective beta blocker. It works by blocking chemicals that attach to receptors on the heart. This slows down your heart rate and lowers your blood pressure.
Hydrochlorothiazide is a thiazide diuretic (water pill) that makes you urinate more. It works in your kidneys to remove extra water and certain electrolytes, which helps lower your blood pressure.

Ziac is typically started at 2.5 mg/6.25 mg (bisoprolol / hydrochlorothiazide) by mouth once daily. If needed, your provider will raise your dose every 2 weeks. The maximum recommended dose of Ziac is 20 mg/12.5 mg (bisoprolol / hydrochlorothiazide) by mouth once daily.

Ziac is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have any of the following:
Sinus bradycardia (a type of slow heartbeat)
Heart block greater than first degree
Shock
Heart failure
Not producing urine
Allergy to sulfa-containing medications

Serious side effects are rare with Ziac. Contact your healthcare provider immediately if you experience any of the following.

Severe allergic reaction: difficulty breathing, swelling of the tongue, mouth, or throat, hives
Heart failure: trouble breathing, fast weight gain, feeling very tired, chest pain, swelling in the legs, ankles, or feet
Bronchospasm: tightness in the chest, trouble catching your breath, difficulty breathing, wheezing, cough, dizziness, extreme tiredness

The following medications may interact with Ziac:

Duramed Pharmaceuticals

Ziac hasn’t been well-studied in human pregnancies. But animal studies suggest that it can cause harm to pregnant mothers and unborn babies. Please speak with your healthcare provider right away if you become pregnant or want to become pregnant.

• Bisoprolol/Hydrochlorothiazide