Key facts about Trihexyphenidyl
What dosages is Trihexyphenidyl available in?
Trihexyphenidyl is available as a 2 mg and 5 mg oral tablet.
What is Trihexyphenidyl used for?
Trihexyphenidyl is an anticholinergic medication that is used to treat Parkinson’s disease (PD) as well as movement problems (extrapyramidal symptoms or EPS) caused by central nervous system medications.
How does Trihexyphenidyl work?
Trihexyphenidyl is an anticholinergic medication. It works by blocking acetylcholine, a chemical that affects different functions in the body, including movement. In doing so, Trihexyphenidyl relaxes your muscles to prevent muscle spasms and tremors.
How do I take Trihexyphenidyl?
Trihexyphenidyl is typically started at a low dose and gradually increased. The usual dose is 5 mg to 15 mg by mouth per day. The dose can be split up into 3 doses and taken with meals.
Is it safe for me to take Trihexyphenidyl?
Trihexyphenidyl is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have angle-closure glaucoma.
Trihexyphenidyl Common Side Effects
Common side effects of Trihexyphenidyl include:
- Dry mouth
- Blurry vision
- Dizziness
- Nausea
- Nervousness
Trihexyphenidyl Serious Side Effects
Serious side effects are rare with Trihexyphenidyl. Contact your healthcare provider immediately if you experience any of the following.
- Neuroleptic malignant syndrome: stiff muscles, sweating, fever, fast heartbeat, irregular pulse
Effects of other drugs, drug classes and over-the-counter products on Trihexyphenidyl
The following medications may interact with Trihexyphenidyl:
- Cannabinoids, barbituates, opiates, and alcohol – May have additive effects with Trihexyphenidyl,and thus, an abuse potential exists
- Concurent use of alcohol or other CNS depressants – May cause increased sedative effects
- Monoamine oxidase inhibitors and trcyclic antidepressants – May intensify the anticholinergic effects
Who makes Trihexyphenidyl?
Various FDA-approved generic manufacturers
Is Trihexyphenidyl safe in pregnancy?
It is not known if Trihexyphenidyl will harm your unborn baby. If you become pregnant while receiving Trihexyphenidyl, talk to your healthcare provider.













