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Triamterene/HCTZ contains triamterene/hydrochlorothiazide and is available as a 37.5 mg/25 mg or 75 mg/50 mg oral capsule.

Triamterene/HCTZ is a combination diuretic (water pill) and is used to treat high blood pressure, and swelling.

Triamterene/HCTZ is a combination medication. Hydrochlorothiazide is a thiazide diuretic (water pill) that makes you urinate more. It works in your kidneys to remove extra water and certain electrolytes (like sodium and potassium), which helps lower your blood pressure and lessen swelling throughout your body. Triamterene is a potassium-sparing diuretic (water pill). It also works in your kidneys to remove extra water and electrolytes, but it doesn’t remove potassium from your body. This helps lower your blood pressure and swelling while preventing your blood potassium levels from dropping low.

Triamterene/HCTZ is typically taken by mouth once daily around the same time each day,

Triamterene/HCTZ is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you are receiving other potassium-sparing agents such as spironolactone, amiloride, or other formulations containing triamterene or if you have anuria, acute and chronic renal insufficiency or significant renal impairment.

Common side effects of Triamterene/HCTZ:

• Headache
• Tiredness
• Dizziness
• Muscle cramps

Serious side effects are rare with Triamterene/HCTZ. Contact your healthcare provider immediately if you experience any of the following.

• Serious skin reaction: fever, sore throat, skin pain, rash that spreads, blisters, peeling skin
• Dangerously high potassium levels: feeling that heart is racing, trouble breathing, chest pain, nausea, vomiting, weakness, tingling sensation
• High levels of acid in the blood (acidosis): confusion, fast heartbeat, feeling sick to your stomach, headache, tiredness
• Severe allergic reactions: severe rash, trouble breathing, closing of the throat

The following medications may interact with Triamterene/HCTZ:

• Angiotensin-converting Enzyme Inhibitors – Potassium-sparing agents should be used with caution in conjunction with angiotensin-converting enzyme (ACE) inhibitors due to an increased risk of hyperkalemia
• Oral Hypoglycemic Drugs – Concurrent use with chlorpropamide may increase the risk of severe hyponatremia
• Nonsteroidal Anti-inflammatory Drugs – A possible interaction resulting in acute renal failure has been reported in a few patients on DYAZIDE when treated with indomethacin, a nonsteroidal anti-inflammatory agent. Caution is advised in administering nonsteroidal anti-inflammatory agents with DYAZIDE
• Lithium – Lithium generally should not be given with diuretics because they reduce its renal clearance and increase the risk of lithium toxicity

Various FDA-approved generic manufacturers

It is not known if Triamterene/HCTZ will harm your unborn baby. If you become pregnant while receiving DYAZIDE, talk to your healthcare provider. Triamterene/HCTZ should be used during pregnancy only if the potential benefit justifies the risk to the fetus.

• Maxzide