View tizanidine savings options available to you including Manufacturer Coupons, Rx Advantage Savings Card, Canadian Prescription Savings or tizanidine Patient Assistance Program.

Programs are suitable for individuals who want to buy tizanidine without insurance, with insurance or for those who are underinsured. You can pay as little as $0 per fill.*

Manufactured by various FDA-approved generic manufacturers.

*Applicable to Drug Coupons & Patient Assistance Programs

This content is intended for US audiences only

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Updated on 24 Apr 2024

Learn more about tizanidine

What dosages is tizanidine available in?

What dosages is tizanidine available in?

tizanidine is available as a 2 mg, 4 mg oral tablet and a 2 mg, 4 mg, and 6 mg oral capsule.

What is tizanidine used for?

What is tizanidine used for?

tizanidine is an alpha-2 receptor agonist that is used to treat muscle stiffness and rigidity.

How does tizanidine work?

How does tizanidine work?

tizanidine is a type of muscle relaxer called an alpha-2 adrenergic receptor agonist. It works by slowing down nerves in your spinal column that control muscle tone. When those nerves slow down, your muscles relax.

How do I take tizanidine?

How do I take tizanidine?

tizanidine is typically started at 2 mg by mouth every 6 to 8 hours, as needed (up to 3 doses a day). If needed, your provider might raise your dose every few days, up to a total of 36 mg per day.
Your dose might be different if you have liver or kidney problems.

Is it safe for me to take tizanidine?

Is it safe for me to take tizanidine?

tizanidine is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you are taking a potent inhibitor of CYP1A2, such as fluvoxamine or ciprofloxacin.

tizanidine Common Side Effects

tizanidine Common Side Effects

  • Common side effects of tizanidine:
  • Dry mouth
  • Sleepiness
  • Weakness
  • Dizziness
  • Urinary tract infection
  • tizanidine Serious Side Effects

    tizanidine Serious Side Effects

    Serious side effects are rare with tizanidine. Contact your healthcare provider immediately if you experience any of the following.

    Allergic reaction: trouble breathing, itchy skin or rash, closing of the throat or swelling of the tongue

    Effects of other drugs, drug classes and over-the-counter products on tizanidine

    Effects of other drugs, drug classes and over-the-counter products on tizanidine

    The following medications may interact with tizanidine:

  • Fluvoxamine: Concomitant use of fluvoxamine and tizanidine is contraindicated. Changes in pharmacokinetics of tizanidine when administered with fluvoxamine resulted in significantly decreased blood pressure, increased drowsiness, and increased psychomotor impairment.
  • Ciprofloxacin: Concomitant use of ciprofoxacin and tizanidine is contraindicated.
  • CYP1A2 Inhibitors other than Fluvoxamine and Ciprofloxacin: Because of potential drug interactions, concomitant use of tizanidine with other CYP1A2 inhibitors, such as zileuton, fluoroquinolones other than strong CYP1A2
  • inhibitors (which are contraindicated), antiarrythmics (amiodarone, mexiletine, propafenone, and verapamil), cimetidine, famotidine, oral contraceptives, acyclovir, and ticlopidine) should be avoided. If their use is clinically necessary, therapy should be initiated with 2 mg dose and increased in 2–4 mg steps daily based on patient response to therapy. If adverse reactions such as hypotension, bradycardia, or excessive drowsiness occur, reduce or discontinue tizanidine therapy.
  • Oral Contraceptives: Concomitant use of tizanidine with oral contraceptives is not recommended. However, if concomitant use is clinically necessary, initiate tizanidine with a single 2 mg dose and increase in 2–4 mg steps daily based on patient response to therapy. If adverse reactions such as hypotension, bradycardia, or excessive drowsiness occur
  • reduce or discontinue tizanidine therapy.
  • Alcohol: Alcohol increases the overall amount of drug in the bloodstream after a dose of tizanidine.
  • Other CNS Depressants: The sedative effects of tizanidine with CNS depressants (e.g., benzodiazepines, opioids, tricyclic antidepressants) may be additive. Monitor patients who take tizanidine with another CNS depressant for symptoms of excess sedation.
  • α2-adrenergic agonists: Because hypotensive effects may be cumulative, it is not recommended that tizanidine be used with other α2-adrenergic agonist.
  • Who makes tizanidine?

    Who makes tizanidine?

    Various FDA-approved generic manufacturers

    Is tizanidine safe in pregnancy?

    Is tizanidine safe in pregnancy?

    Based on animal data, tizanidine may cause fetal harm. You should talk to your healthcare provider before taking this medication if you are pregnant. tizanidine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.


    What to do if you missed your tizanidine dose

    The FDA's medical product safety reporting program for health professionals, patients and consumers.

    Learn more about reporting side effects
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    Medical Disclaimer

    NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

    The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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