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Tizanidine is available as a 2 mg, 4 mg oral tablet and a 2 mg, 4 mg, and 6 mg oral capsule.

Tizanidine is an alpha-2 receptor agonist that is used to treat muscle stiffness and rigidity.

Tizanidine is a type of muscle relaxer called an alpha-2 adrenergic receptor agonist. It works by slowing down nerves in your spinal column that control muscle tone. When those nerves slow down, your muscles relax.

Tizanidine is typically started at 2 mg by mouth every 6 to 8 hours, as needed (up to 3 doses a day). If needed, your provider might raise your dose every few days, up to a total of 36 mg per day.
Your dose might be different if you have liver or kidney problems.

Tizanidine is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you are taking a potent inhibitor of CYP1A2, such as fluvoxamine or ciprofloxacin.

Serious side effects are rare with Tizanidine. Contact your healthcare provider immediately if you experience any of the following.

Allergic reaction: trouble breathing, itchy skin or rash, closing of the throat or swelling of the tongue

The following medications may interact with Tizanidine:

Various FDA-approved generic manufacturers

Based on animal data, Tizanidine may cause fetal harm. You should talk to your healthcare provider before taking this medication if you are pregnant. Tizanidine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

• Zanaflex