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ZANAFLEX

ZANAFLEX

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Manufactured by Acorda Therapeutics Inc.

*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.

This content is intended for US audiences only

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ZANAFLEX Uses, Side Effects, Interactions, Warnings & Dosing

What is ZANAFLEX?

What is ZANAFLEX?

ZANAFLEX is the brand name for tizanidine and is available as an oral tablet and capsule.

What dosages is ZANAFLEX available in?

What dosages is ZANAFLEX available in?

ZANAFLEX is available as a 2 mg, 4 mg oral tablet and a 2 mg, 4 mg, and 6 mg oral capsule.

What is ZANAFLEX used for?

What is ZANAFLEX used for?

ZANAFLEX is an alpha-2 receptor agonist that is used to treat muscle stiffness and rigidity.

How does ZANAFLEX work?

How does ZANAFLEX work?

ZANAFLEX is a type of muscle relaxer called an alpha-2 adrenergic receptor agonist. It works by slowing down nerves in your spinal column that control muscle tone. When those nerves slow down, your muscles relax.

How do I take ZANAFLEX?

How do I take ZANAFLEX?

ZANAFLEX is typically started at 2 mg by mouth every 6 to 8 hours, as needed (up to 3 doses a day). If needed, your provider might raise your dose every few days, up to a total of 36 mg per day.
Your dose might be different if you have liver or kidney problems.

Is it safe for me to take ZANAFLEX?

Is it safe for me to take ZANAFLEX?

ZANAFLEX is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you are taking a potent inhibitor of CYP1A2, such as fluvoxamine or ciprofloxacin.

ZANAFLEX Common Side Effects

ZANAFLEX Common Side Effects

  • Common side effects of ZANAFLEX:
  • Dry mouth
  • Sleepiness
  • Weakness
  • Dizziness
  • Urinary tract infection
  • ZANAFLEX Serious Side Effects

    ZANAFLEX Serious Side Effects

    Serious side effects are rare with ZANAFLEX. Contact your healthcare provider immediately if you experience any of the following.

    Allergic reaction: trouble breathing, itchy skin or rash, closing of the throat or swelling of the tongue

    Effects of other drugs, drug classes and over-the-counter products on ZANAFLEX

    Effects of other drugs, drug classes and over-the-counter products on ZANAFLEX

    The following medications may interact with ZANAFLEX:

  • Fluvoxamine: Concomitant use of fluvoxamine and ZANAFLEX is contraindicated. Changes in pharmacokinetics of tizanidine when administered with fluvoxamine resulted in significantly decreased blood pressure, increased drowsiness, and increased psychomotor impairment.
  • Ciprofloxacin: Concomitant use of ciprofoxacin and ZANAFLEX is contraindicated.
  • CYP1A2 Inhibitors other than Fluvoxamine and Ciprofloxacin: Because of potential drug interactions, concomitant use of Zanaflex with other CYP1A2 inhibitors, such as zileuton, fluoroquinolones other than strong CYP1A2
  • inhibitors (which are contraindicated), antiarrythmics (amiodarone, mexiletine, propafenone, and verapamil), cimetidine, famotidine, oral contraceptives, acyclovir, and ticlopidine) should be avoided. If their use is clinically necessary, therapy should be initiated with 2 mg dose and increased in 2–4 mg steps daily based on patient response to therapy. If adverse reactions such as hypotension, bradycardia, or excessive drowsiness occur, reduce or discontinue ZANAFLEX therapy.
  • Oral Contraceptives: Concomitant use of ZANAFLEX with oral contraceptives is not recommended. However, if concomitant use is clinically necessary, initiate ZANAFLEX with a single 2 mg dose and increase in 2–4 mg steps daily based on patient response to therapy. If adverse reactions such as hypotension, bradycardia, or excessive drowsiness occur
  • reduce or discontinue ZANAFLEX therapy.
  • Alcohol: Alcohol increases the overall amount of drug in the bloodstream after a dose of ZANAFLEX.
  • Other CNS Depressants: The sedative effects of ZANAFLEX with CNS depressants (e.g., benzodiazepines, opioids, tricyclic antidepressants) may be additive. Monitor patients who take ZANAFLEX with another CNS depressant for symptoms of excess sedation.
  • α2-adrenergic agonists: Because hypotensive effects may be cumulative, it is not recommended that ZANAFLEX be used with other α2-adrenergic agonist.
  • Who makes ZANAFLEX?

    Who makes ZANAFLEX?

    Acorda Therapeutics Inc.

    Is ZANAFLEX safe in pregnancy?

    Is ZANAFLEX safe in pregnancy?

    Based on animal data, ZANAFLEX may cause fetal harm. You should talk to your healthcare provider before taking this medication if you are pregnant. ZANAFLEX should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

    What is the generic name for ZANAFLEX?

    What is the generic name for ZANAFLEX?

    The FDA's medical product safety reporting program for health professionals, patients and consumers.

    Learn more about reporting side effects
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    Medical Disclaimer

    NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

    The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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