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Each actuation from the mouthpiece of Tiotropium Bromide/Olodaterol delivers 2.5 mcg tiotropium (equivalent to 3.124 mcg tiotropium bromide monohydrate), and 2.5 mcg olodaterol (equivalent to 2.736 mcg olodaterol hydrochloride). Two actuations equal one dose.

• Tiotropium Bromide/Olodaterol is a combination of an anticholinergic and a long-acting beta2-adrenergic agonist (LABA) that is indicated for the long-term, once-daily maintenance treatment of patients with chronic obstructive pulmonary disease (COPD)

Tiotropium Bromide/Olodaterol is a combination of two medications that help you breathe better. Tiotropium is a long-acting muscarinic antagonist (LAMA) that prevents your airways from tightening and helps them stay open. Olodaterol is a long-acting beta-2 adrenergic agonist (LABA) that helps relax the muscles in your airways, causing them to open.

• Tiotropium Bromide/Olodaterol is typically dosed as 2 puffs (inhalations) by mouth at the same time every day. Don’t use more than 2 puffs in a 24-hour period

Tiotropium Bromide/Olodaterol is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. Use of a LABA, including Tiotropium Bromide/Olodaterol, without an inhaled corticosteroid is contraindicated in patients with asthma. Hypersensitivity to tiotropium, ipratropium, olodaterol, or any component of this product is another contraindication.

Common side effects of Tiotropium Bromide/Olodaterol:

• Nose and throat infection
• Cough
• Back pain
• Dizziness
• Trouble sleeping
• Blurry vision

Serious side effects are rare with Tiotropium Bromide/Olodaterol. Contact your healthcare provider immediately if you experience any of the following.

• Serious allergic reaction: hives, swelling (lips, tongue, throat), rash, difficulty breathing
• Tightening of airways: sudden shortness of breath, difficulty breathing, coughing, wheezing

The following medications may interact with Tiotropium Bromide/Olodaterol:

• Other adrenergic drugs may potentiate effect. Use with caution
• Xanthine derivatives, steroids, diuretics, or non-potassium sparing diuretics may potentiate hypokalemia or ECG changes. Use with caution
• MAO inhibitors, tricyclic antidepressants, and drugs that prolong QTc interval may potentiate effect on cardiovascular system. Use with extreme caution
• Beta-blockers may decrease effectiveness. Use with caution and only when medically necessary
• Anticholinergics: May interact additively with concomitantly used anticholinergic medications. Avoid administration of Tiotropium Bromide/Olodaterol with other anticholinergic-containing drugs

Various FDA-approved generic manufacturers

There are no adequate and well-controlled clinical studies with Tiotropium Bromide/Olodaterol use in pregnant women. Tiotropium Bromide/Olodaterol should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

• Stiolto