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Stiolto is the brand name for tiotropium bromide and olodaterol inhalation spray and is available as an oral inhalation

Each actuation from the mouthpiece of Stiolto delivers 2.5 mcg tiotropium (equivalent to 3.124 mcg tiotropium bromide monohydrate), and 2.5 mcg olodaterol (equivalent to 2.736 mcg olodaterol hydrochloride). Two actuations equal one dose.

• Stiolto is a combination of an anticholinergic and a long-acting beta2-adrenergic agonist (LABA) that is indicated for the long-term, once-daily maintenance treatment of patients with chronic obstructive pulmonary disease (COPD)

Stiolto is a combination of two medications that help you breathe better. Tiotropium is a long-acting muscarinic antagonist (LAMA) that prevents your airways from tightening and helps them stay open. Olodaterol is a long-acting beta-2 adrenergic agonist (LABA) that helps relax the muscles in your airways, causing them to open.

• Stiolto is typically dosed as 2 puffs (inhalations) by mouth at the same time every day. Don’t use more than 2 puffs in a 24-hour period

Stiolto is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. Use of a LABA, including Stiolto, without an inhaled corticosteroid is contraindicated in patients with asthma. Hypersensitivity to tiotropium, ipratropium, olodaterol, or any component of this product is another contraindication.

Common side effects of Stiolto:

• Nose and throat infection
• Cough
• Back pain
• Dizziness
• Trouble sleeping
• Blurry vision

Serious side effects are rare with Stiolto. Contact your healthcare provider immediately if you experience any of the following.

• Serious allergic reaction: hives, swelling (lips, tongue, throat), rash, difficulty breathing
• Tightening of airways: sudden shortness of breath, difficulty breathing, coughing, wheezing

The following medications may interact with Stiolto:

• Other adrenergic drugs may potentiate effect. Use with caution
• Xanthine derivatives, steroids, diuretics, or non-potassium sparing diuretics may potentiate hypokalemia or ECG changes. Use with caution
• MAO inhibitors, tricyclic antidepressants, and drugs that prolong QTc interval may potentiate effect on cardiovascular system. Use with extreme caution
• Beta-blockers may decrease effectiveness. Use with caution and only when medically necessary
• Anticholinergics: May interact additively with concomitantly used anticholinergic medications. Avoid administration of Stiolto with other anticholinergic-containing drugs

Boehringer Ingelheim Pharmaceuticals, Inc.

There are no adequate and well-controlled clinical studies with Stiolto use in pregnant women. Stiolto should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

• Tiotropium Bromide/Olodaterol