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Soliqua 100/33 is the brand name for insulin glargine/lixisenatide and is available as a subcuataneous injection.

Soliqua 100/33 is available as a 3 mL single-patient-use pen containing 100 units insulin glargine and 33 mcg lixisenatide per mL.

Soliqua 100/33 is a combination medication for diabetes that contains insulin glargine (a long-acting insulin) and lixisenatide (a glucagon-like peptide-1 (GLP-1) receptor agonist).

Soliqua 100/33 is a combination of two medications that work together to lower blood sugar. Insulin glargine is a long-acting insulin. It helps control blood sugar levels throughout the day by helping your body absorb and store sugar from your blood after meals. Lixisenatide is a glucagon-like peptide-1 (GLP-1) receptor agonist. It activates GLP-1, a hormone that helps your pancreas release more insulin, lowers the amount of sugar your liver makes, and slows how fast food leaves your stomach so you feel full longer.

Soliqua 100/33 is injected subcutaneously once a day within the hour prior to the first meal of the day. The maximum daily dose is 60 units (60 units of insulin glargine and 20 mcg of lixisenatide).

Soliqua 100/33 is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:

• During episodes of hypoglycemia
• Serious hypersensitivity to insulin glargine, lixisenatide, or any of the excipients in the product

Common side effects of Soliqua 100/33:

• Nausea
• Low blood sugar
• Common cold symptoms
• Diarrhea
• Headache

Serious side effects are rare with Soliqua 100/33. Contact your healthcare provider immediately if you experience any of the following:

• Inflammation of the pancreas (pancreatitis): severe stomach pain that spreads to your back, nausea, vomiting
• Severely low blood sugar: dizziness, shakiness, feeling confused, feeling irritable or anxious, feeling faint, sweating, extreme hunger, can’t think clearly
• Kidney damage: tiredness, dry and itchy skin, urinating more often, bloody or foamy urine, swelling in your feet or ankles, muscle cramping
• Low potassium levels: weakness, muscle cramps or twitches, constipation, abnormal heartbeat, tiredness, trouble breathing
• Gallbladder problems: severe upper stomach and back pain, yellowing of the skin or eyes, fever, nausea, vomiting
• Severe allergic reaction: rash; hives; swelling of face, tongue, and throat; trouble breathing

The following medications may interact with Soliqua 100/33:

• Drugs that affect glucose levels
• Antiadrenergic Drugs (e.g., beta-blockers, clonidine, guanethidine, and reserpine)
• Oral medications since Soliqua 100/33 delays gastric emptying

Sanofi-Aventis U.S.

Soliqua 100/33 should be used during pregnancy only if the potential benefit justifies the potential risk to your unborn baby. Talk to your doctor if you are already pregnant or if you have plans on becoming pregnant. They will recommend what is best for you.

• Insulin Glargine/Lixisenatide