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Insulin Glargine/Lixisenatide is available as 100 units of insulin glargine per mL and 33 mcg of lixisenatide per mL in a 3 mL single-patient use pen.

Insulin Glargine/Lixisenatide is an insulin/GLP-1 agonist used to treat type 2 diabetes.

Insulin Glargine/Lixisenatide is a combination of two medications that work together to lower blood sugar.

• Insulin glargine (a long-acting insulin) is a hormone that directly lowers sugar in the blood
• Lixisenatide is a glucagon-like peptide-1 (GLP-1) agonist. It tells your body to release more insulin, stops the body from releasing more sugar, and slows down digestion

The typical starting dose is 15 units (equivalent to 15 units of insulin glargine with 5 mcg of lixisenatide) injected under the skin once a day, within an hour before the first meal of the day. The dose will be adjusted based on your blood sugar readings, up to a maximum dose of 60 units a day (equivalent to 60 units of insulin glargine with 20 mcg of lixisenatide).

Insulin Glargine/Lixisenatide is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have symptoms of low blood sugar.

Common side effects of Insulin Glargine/Lixisenatide:

• Nausea
• Low blood sugar
• Common cold-like symptoms
• Diarrhea
• Headache

Serious side effects are rare with Insulin Glargine/Lixisenatide. Contact your healthcare provider immediately if you experience any of the following.

• Allergic reaction

• The following medications may interact with Insulin Glargine/Lixisenatide:
• Drugs that affect glucose metabolism: Adjustment of Insulin Glargine/Lixisenatide dosage may be needed; closely monitor blood glucose
• Antiadrenergic Drugs (e.g., beta-blockers, clonidine, guanethidine, and reserpine): Hypoglycemia signs and symptoms may be reduced
• Effects of delayed gastric emptying on oral medications: Lixisenatide delays gastric emptying which may impact absorption of concomitantly administered oral medications. Oral contraceptives and other medications such as antibiotics and acetaminophen should be taken at least 1 hour prior to Insulin Glargine/Lixisenatide administration or 11 hours after

Various FDA-approved generic manufacturers

It is not known if Insulin Glargine/Lixisenatide will harm your unborn baby. Tell
your healthcare provider if you are pregnant or plan to become pregnant while using Insulin Glargine/Lixisenatide.

• Soliqua
• Soliqua 100/33