insulin glargine/lixisenatide

insulin glargine/lixisenatide

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Manufactured by various FDA-approved generic manufacturers.

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Updated on 24 Apr 2024

insulin glargine/lixisenatide Uses, Side Effects, Interactions, Warnings & Dosing

What dosages is insulin glargine/lixisenatide available in?

What dosages is insulin glargine/lixisenatide available in?

insulin glargine/lixisenatide is available as 100 units of insulin glargine per mL and 33 mcg of lixisenatide per mL in a 3 mL single-patient use pen.

What is insulin glargine/lixisenatide used for?

What is insulin glargine/lixisenatide used for?

insulin glargine/lixisenatide is an insulin/GLP-1 agonist used to treat type 2 diabetes.

How does insulin glargine/lixisenatide work?

How does insulin glargine/lixisenatide work?

insulin glargine/lixisenatide is a combination of two medications that work together to lower blood sugar.

  • Insulin glargine (a long-acting insulin) is a hormone that directly lowers sugar in the blood
  • Lixisenatide is a glucagon-like peptide-1 (GLP-1) agonist. It tells your body to release more insulin, stops the body from releasing more sugar, and slows down digestion
How do I take insulin glargine/lixisenatide?

How do I take insulin glargine/lixisenatide?

The typical starting dose is 15 units (equivalent to 15 units of insulin glargine with 5 mcg of lixisenatide) injected under the skin once a day, within an hour before the first meal of the day. The dose will be adjusted based on your blood sugar readings, up to a maximum dose of 60 units a day (equivalent to 60 units of insulin glargine with 20 mcg of lixisenatide).

Is it safe for me to take insulin glargine/lixisenatide?

Is it safe for me to take insulin glargine/lixisenatide?

insulin glargine/lixisenatide is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have symptoms of low blood sugar.

insulin glargine/lixisenatide Common Side Effects

insulin glargine/lixisenatide Common Side Effects

Common side effects of insulin glargine/lixisenatide:

  • Nausea
  • Low blood sugar
  • Common cold-like symptoms
  • Diarrhea
  • Headache
insulin glargine/lixisenatide Serious Side Effects

insulin glargine/lixisenatide Serious Side Effects

Serious side effects are rare with insulin glargine/lixisenatide. Contact your healthcare provider immediately if you experience any of the following.

  • Allergic reaction
Effects of other drugs, drug classes and over-the-counter products on insulin glargine/lixisenatide

Effects of other drugs, drug classes and over-the-counter products on insulin glargine/lixisenatide

  • The following medications may interact with insulin glargine/lixisenatide:
  • Drugs that affect glucose metabolism: Adjustment of insulin glargine/lixisenatide dosage may be needed; closely monitor blood glucose
  • Antiadrenergic Drugs (e.g., beta-blockers, clonidine, guanethidine, and reserpine): Hypoglycemia signs and symptoms may be reduced
  • Effects of delayed gastric emptying on oral medications: Lixisenatide delays gastric emptying which may impact absorption of concomitantly administered oral medications. Oral contraceptives and other medications such as antibiotics and acetaminophen should be taken at least 1 hour prior to insulin glargine/lixisenatide administration or 11 hours after
Who makes insulin glargine/lixisenatide?

Who makes insulin glargine/lixisenatide?

Various FDA-approved generic manufacturers

Is insulin glargine/lixisenatide safe in pregnancy?

Is insulin glargine/lixisenatide safe in pregnancy?

It is not known if insulin glargine/lixisenatide will harm your unborn baby. Tell
your healthcare provider if you are pregnant or plan to become pregnant while using insulin glargine/lixisenatide.


What to do if you missed your insulin glargine/lixisenatide dose

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Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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