Save up to 90% on Slynd with Coupons, Discount Cards & Patient Assistance Programs

Slynd is the brand name for drospirenone and is available as a progestin-only oral contraceptive tablet. It is also known as a POP (progestin-only pill) or “mini-pill” and does not contain oestrogen.

Slynd is available as 4 mg drospirenone tablets. Each blister pack contains 28 tablets: 24 white active tablets (each containing 4 mg drospirenone) and 4 green inert tablets (containing no active hormone). The recommended dose is one tablet taken orally once daily for 28 consecutive days.

Slynd is a progestin-only oral contraceptive used by females of reproductive potential to prevent pregnancy.

Slynd works primarily by suppressing ovulation. It contains drospirenone, a synthetic progestin and spironolactone analogue with anti-mineralocorticoid activity.

By maintaining consistent progestin levels throughout the 28-day cycle — including during the 4-day inert tablet phase — Slynd provides continuous ovulation suppression. Additional contraceptive effects may include changes to cervical mucus and the uterine lining that make fertilisation and implantation less likely.

Take one Slynd tablet orally once daily, at approximately the same time each day, for 28 consecutive days:

• Days 1–24: Take one white active tablet daily
• Days 25–28: Take one green inert tablet daily

Begin a new blister pack immediately after finishing the previous pack, on the same day of the week.

Day 1 Start: Start your first pack on the first day of your menstrual period.

Switching from another method: Start Slynd on the day your next dose or pack of your previous method would have been due (or on the day of removal for implants, IUDs, or IUS).

Missed white (active) tablets:
• If you miss 1 white tablet: Take it as soon as you remember. No back-up contraception is needed.
• If you miss 2 or more white tablets: Take the last missed tablet as soon as possible and continue one tablet per day. Use non-hormonal back-up contraception (e.g. condoms) for the next 7 days.

Missed green (inert) tablets: No action required — skip the missed green tablet and continue as normal.

Gastrointestinal disturbance: If you vomit or have diarrhoea within 3–4 hours of taking a tablet, take the next day’s tablet as soon as possible (within 12 hours of your usual time). If more than 2 tablets are missed as a result, use back-up contraception for 7 days.

Slynd is a safe and effective contraceptive when used as directed for its FDA-approved indication. However, like all medicines, it may not be suitable for everyone.

Do not take Slynd if you have:
• Renal (kidney) impairment
• Adrenal insufficiency
• Presence or history of cervical cancer or progestin-sensitive cancers
• Liver tumours (benign or malignant) or hepatic (liver) impairment
• Undiagnosed abnormal uterine bleeding

Tell your healthcare provider before starting Slynd if you:
• Are pregnant or think you may be pregnant
• Have ever had blood clots (DVT, pulmonary embolism, stroke, or heart attack)
• Have diabetes (you may need closer blood sugar monitoring)
• Have a history of depression
• Take medicines that may raise potassium levels (e.g. ACE inhibitors, potassium-sparing diuretics, NSAIDs, heparin) — a serum potassium blood test should be performed before and during the first treatment cycle

Note: Slynd contains drospirenone, which has anti-mineralocorticoid activity comparable to a 25 mg dose of spironolactone. It has the potential to cause elevated potassium (hyperkalemia), particularly in high-risk patients.

Common side effects of Slynd (occurring in >1% of users in clinical studies):
• Acne (3.8%)
• Metrorrhagia / breakthrough bleeding (2.8%)
• Headache (2.7%)
• Breast pain (2.2%)
• Weight gain (1.9%)
• Dysmenorrhea / menstrual cramps (1.9%)
• Nausea (1.8%)
• Vaginal haemorrhage (1.7%)
• Decreased libido (1.3%)
• Breast tenderness (1.2%)
• Irregular menstruation (1.2%)

Blood-sugar irregularities are also very common — up to 64.4% of users experience unscheduled bleeding or spotting in the first cycle, decreasing to approximately 40% by cycle 13.

Serious side effects are uncommon with Slynd but contact your healthcare provider immediately if you experience any of the following:

Hyperkalemia (high potassium): Weakness or numbness in an arm or leg, heart palpitations or irregular heartbeat, nausea, vomiting, severe chest pain, or shortness of breath. Risk is highest in patients with kidney or adrenal conditions, or those taking potassium-raising medications.

Thromboembolic disorders (blood clots): Leg pain that won’t go away, sudden severe headache, sudden shortness of breath, sudden vision change, chest pain, limb weakness, or difficulty speaking. Discontinue Slynd immediately if a clot occurs.

Ectopic pregnancy: Severe abdominal or pelvic pain in a patient who becomes pregnant while on Slynd may indicate a pregnancy outside the uterus — a medical emergency requiring urgent care.

Liver problems: Yellowing of the skin or eyes (jaundice), dark urine, pale stools, or severe abdominal pain. Discontinue Slynd if jaundice or acute liver disturbance develops.

Bone loss: Drospirenone lowers oestrogen levels; whether this causes clinically relevant bone mineral density loss is unknown.

Depression: Carefully observe patients with a history of depression. Discontinue Slynd if depression recurs to a serious degree.

Drugs that reduce Slynd’s effectiveness (CYP3A4 inducers — use back-up contraception):
• Anticonvulsants: phenytoin, carbamazepine, oxcarbazepine, felbamate, rufinamide, barbiturates
• Antibiotics/antifungals: rifampicin, rifabutin, griseofulvin
• Other: efavirenz, bosentan, aprepitant, St. John’s Wort
Back-up non-hormonal contraception should be used while taking these medicines and for 28 days after stopping them.

Drugs that increase drospirenone (DRSP) exposure (CYP3A4 inhibitors — monitor potassium):
• Azole antifungals: ketoconazole, itraconazole, voriconazole
• HIV/HCV protease inhibitors: indinavir, boceprevir
• Antibiotics: clarithromycin
Co-administration with strong CYP3A4 inhibitors has been shown to increase DRSP exposure by up to 2.68-fold.

Drugs that may increase serum potassium (hyperkalemia risk — check potassium levels):
• ACE inhibitors
• Angiotensin-II receptor antagonists (ARBs)
• Potassium-sparing diuretics
• Potassium supplements
• Heparin
• Aldosterone antagonists (e.g. spironolactone)
• NSAIDs

Always inform your healthcare provider and pharmacist of all medicines, supplements, vitamins, and herbal products you are taking.

Exeltis USA, Inc.

Slynd is not recommended during pregnancy and should be discontinued if pregnancy is confirmed during treatment.

Based on epidemiological studies and meta-analyses, there is little or no increased risk of birth defects in children of females who inadvertently use oral progestins during early pregnancy. However, there is no benefit to continuing hormonal contraception once pregnancy is confirmed.

Fertility: You may stop Slynd whenever you wish. Fertility is expected to return promptly after stopping.

Breastfeeding: Drospirenone is excreted in breast milk in negligible amounts. The estimated average infant daily dose for an exclusively breastfed infant is approximately 840 ng/kg/day (relative infant dose 1.5%), which is not expected to cause adverse effects. No adverse effects on milk production, infant health, growth, or development have been found with progestin-only pills in general.

• Drospirenone