Drospirenone Generic

FDA badge
Looking for ways to save up to 90%* on your FDA-approved branded and generic medications?
You could enjoy savings using Now Patient’s mail-order online pharmacy or the Now Patient Rx Advantage Card at over 65,000 pharmacies.
US Flag
United States
*Based on the difference between the U&C price submitted and the price the patient paid, as of April 2023.

Mail Order Pharmacy

  1. Medication
    You save
    US Flag
  2. Drospirenone Ethinyl Estradiol
    Generic for Yasmin, Syeda, Ocella, Zarah
    28 pack blister pack of tabletss $10.26 USD
    Save $53.64
Now Patient Parcel

Or register now to use our savings card

Savings Card

Save up to 90% of your branded or generic medications using the Now Patient Rx Advantage Card

Do you need a prescription for drospirenone?

Yes, drospirenone is only available with a valid physician Rx.

How much is drospirenone without Insurance in the US?

Our website gives two competitive savings options to US customers who wish to purchase drospirenone, as either a brand or generic, if available. The first is access to medications through our mail-order online pharmacy. The second is by using the Now Patient Rx Advantage Card, which can be used in over 65,000 pharmacies nationwide, across America. If you are insured, then in most cases, the cash price will be significantly cheaper than the copay.

What will my out-of-pocket cost be for drospirenone in the US?

There are no out-of-pocket (OOP) costs because we are currently only offering a cash-based option to purchase medications.

Is Now Patient a drospirenone savings card?

Yes. Save up to 90% on your drospirenone with the FREE Now Patient Rx Advantage card*.
*Based on the difference between the U&C submitted by the pharmacy and the price the patients pay.

Can you handle Rx transfers for home delivery in the US?

Yes. If you use the mail-order online pharmacy option, then we can handle requests by you to have your prescription transferred to our pharmacy for home delivery. We can even help you manage your refills by giving you timely reminders, so you do not run out of your medication.

Is Now Patient a drospirenone coupon provider in the US?

No. Now Patient does not provide drospirenone coupons or FREE drospirenone samples.

Do you accept commercial, Medicare or Medicaid coverage for drospirenone in the US?

No. Currently, we only offer cash-based options for purchase, therefore we do not require your insurance benefit details. In the future, our plan is to be able to handle commercial insurance, Medicare and Medicaid including cases where you have multiple health plans that provide benefit coverage (e.g. Medicaid and Commercial). We also anticipate being able to handle more complex scenarios such as using primary insurance combined with a manufacturer copay assistance program.

Does Now Patient work with Medicare?

Our cash-based prices for medications are typically cheaper than Medicare copays. We do not bill Medicare Part D (standalone drug coverage) or Medicare Advantage (combined health and drug coverage). When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

Does Now Patient work with Commercial Insurance?

Our cash-based prices for medications are typically cheaper than commercial plan copays. We do not bill your commercial plan. When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

What should you do if you use too much drospirenone?


Call your doctor right away or seek immediate medical attention if your symptoms do not improve or they become worse after using drospirenone. You can also call 800-222-1222 to reach the American Association of Poison Control Centers or use its online resource if you think you’ve used too much drospirenone. But if you have severe symptoms, call 911 (or your local emergency number) immediately or go to the nearest emergency room.


If you think it is an emergency, call 999 or find your nearest A&E
If you need help now, but it’s not an emergency go to 111.nhs.uk or call 111. Alternatively you can speak to one of our pharmacists or use the Now Patient app to make an appointment with your GP.

What should I do if I miss my dose?

There are occasions when people forget to take their medication at correct prescribed times. This may not only have an effect on potentially making the medication less effective but it may also inadvertently lead to taking doses too close together, thereby increasing the risks of side effects.

Click here to find out what to do if you forgot to take your medication

What is generic drospirenone?

Generic drospirenone refers to the non-brand-name version of the medication. It contains the same active ingredient as the brand-name drug but is typically less expensive.

FDA approval of drospirenone

Drospirenone (DRSP) is approved by the U.S. Food and Drug Administration (FDA) for use in combination with ethinyl estradiol as an oral contraceptive.

Active ingredient of drospirenone

The active ingredient of drospirenone is drospirenone.

US brand name of drospirenone and manufacturer

Drospirenone is available in the US under various brand names, including Yasmin, Yaz, Loryna, Ocella, Syeda, and Nikki. It is manufactured by various pharmaceutical companies.

UK brand name of drospirenone and manufacturer

In the UK, drospirenone is available under various brand names, including Yasmin and Yacella. The manufacturer may vary depending on the brand name.

Prescription requirement for drospirenone

A prescription (Rx) is required for drospirenone in both the US and the UK.

Availability of drospirenone in the UK with NHS prescription

Drospirenone is available in the UK with an NHS prescription.

Conditions treated by drospirenone

Drospirenone is primarily used as an oral contraceptive also known as birth control pills or COCs to prevent pregnancy. It is a combined oral contraceptive that contains both estrogen (ethinyl estradiol) and progestin (drospirenone). It works by preventing ovulation, thickening the cervical mucus to prevent sperm from reaching the egg, and altering the lining of the uterus to make it less receptive to implantation.

This medicine is also used to treat premenstrual dysphoric disorder (PMDD) and moderate acne in women at least 14 years of age.

How does drospirenone work?

Drospirenone works by suppressing the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland. This inhibits the development and release of eggs from the ovaries, preventing pregnancy.

The exact molecular mechanism of action for drospirenone involves several key processes. Firstly, drospirenone binds to the progesterone receptor in target tissues, such as the uterus and ovaries. This binding activates the progesterone receptor and leads to changes in gene expression.

Drospirenone also has anti-mineralocorticoid activity, which means it acts as an antagonist to the mineralocorticoid receptor. This leads to a reduction in sodium and water retention in the body, resulting in an overall decrease in fluid retention.

Furthermore, drospirenone has anti-androgenic activity. It inhibits the binding of androgens, such as testosterone, to their respective receptors. By doing so, drospirenone helps reduce the effects of androgens, such as excessive hair growth and acne.

Forms of drospirenone available

Drospirenone is available in the form of oral tablets.

Dosage of drospirenone

The dosage of drospirenone may vary depending on the specific product and the prescribed regimen. It is important to follow the recommended dosage instructions provided by the healthcare provider or the instructions on the product label.

Directions for drospirenone use

Drospirenone tablets should be taken exactly as directed by the healthcare provider. The tablets are usually taken once daily, at the same time each day, for a 28-day cycle. It is important to take the tablets consistently to maintain contraceptive effectiveness.

Warnings and precautions for drospirenone

  • Drospirenone should not be used by individuals who are pregnant or breastfeeding
  • This medication may raise your blood pressure. Check your blood pressure regularly and tell your doctor if the results are high
  • It may increase the risk of blood clots, stroke, heart attack, and other serious cardiovascular events. Discuss the risks and benefits with a healthcare provider, especially if you have any underlying health conditions
  • Patients with different medical backgrounds, including those at risk of cardiovascular diseases or with liver function impairment, should consult their healthcare provider before using drospirenone
  • You should not take drospirenone if you have: coronary artery disease, undiagnosed vaginal bleeding, liver disease or liver cancer, severe migraine headaches, also take certain hepatitis C medication, will have major surgery, smoke and are over 35, or if you have ever had a heart attack, a stroke, a blood clot, jaundice caused by pregnancy or contraceptive pill or breast cancer
  • It may interact with certain medications, including certain antibiotics and antifungal medications such as ketoconazole
  • Inform the healthcare provider about all medications being taken. It is important to inform your healthcare provider about all the medications you are taking, including prescription drugs, over-the-counter meds, and supplements, before starting drospirenone

Drug interactions for drospirenone

  • Grapefruit juice can interact with certain medications, including drospirenone. This citrusy beverage inhibits the enzyme responsible for breaking down drugs in the body, leading to higher levels of medication in the bloodstream. If you are taking drospirenone, it is recommended to avoid consuming grapefruit juice to prevent potential drug interactions
  • When taking drugs like warfarin and heparin with drospirenone, there is an increased risk of bleeding or bruising due to their combined anticoagulant effects. It is important to closely monitor your blood clotting status if you are on both these medications simultaneously
  • Taking rifampin alongside drospirenone may decrease the effectiveness of hormonal contraceptives like birth control pills containing drospirenone. Alternative methods of contraception should be considered while using rifampin and communication with a healthcare provider is essential
  • Drospirenone can increase potassium levels in the body, so combining it with potassium-sparing diuretics like spironolactone can further increase potassium levels and potentially lead to hyperkalemia (high potassium levels). This can be dangerous and may cause heart rhythm disturbances. It is important to monitor potassium levels when using both medications simultaneously
  • Other medications can raise potassium levels in the blood. These include certain angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), nonsteroidal anti-inflammatory drugs (NSAIDs), and potassium supplements. Combining these medications with drospirenone may increase the risk of hyperkalemia

Use of drospirenone in special populations

Drospirenone should be used with caution in individuals with certain medical conditions, such as liver disease or a history of blood clotting disorders. It is important to discuss the risks and benefits with a healthcare provider.

Possible side effects of drospirenone

Common side effects of drospirenone may include nausea, breast tenderness, breast pain, breakthrough bleeding, and mood changes. Serious side effects are rare but can occur. Promptly report any concerning symptoms to a healthcare provider.

Similar drugs to drospirenone

Norgestimate, desogestrel, norethindrone, levonorgestrel, gestodene.


Now Patient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information in this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

Stefano Mirabello Medical Reviewer
Pharmacist / B.Pharm
To improve the lives of everyone by making high-quality care accessible and convenient

As technologists and clinicians, we built Now Patient to be more than just an online pharmacy.  We are here to improve lives.  Our service gives you access to smart features & resources that can help empower you to take control of your health and improve your health outcomes.  All this, in one place, for FREE.  We strive to bring a fresh perspective to managing health. Not play by the rules. Now Patient can be accessed by downloading the App or using your web browser.

A mobile app displaying a health care service.
Join the thousands of happy customers in the US and UK already using Now Patient

Manage your health and prescriptions all in one place for FREE.  Available to use by downloading the App, or using your web browser.

Reminders page
Your Questions Answered
For your peace of mind, we can answer your health questions quickly
If you want to learn more about the range of services that we provide which can help manage and improve your health, then just click the button below.
Find your answers