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selegiline hydrochloride

selegiline hydrochloride

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Manufactured by various FDA-approved generic manufacturers.

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This content is intended for US audiences only

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Navin Khosla NowPatientGreen tick
Updated on 24 Apr 2024

Learn more about selegiline hydrochloride

What dosages is selegiline hydrochloride available in?

What dosages is selegiline hydrochloride available in?

selegiline hydrochloride is available as a 1.25 mg orally disintegrating tablet.

What is selegiline hydrochloride used for?

What is selegiline hydrochloride used for?

selegiline hydrochloride is a MAO-B inhibitor and is used to relieve “wearing-off” symptoms in people with Parkinson’s disease who are taking combination medications containing carbidopa and levodopa (e.g., Sinemet (carbidopa / levodopa), Rytary (carbidopa / levodopa)).

How does selegiline hydrochloride work?

How does selegiline hydrochloride work?

selegiline hydrochloride is a monoamine oxidase type B (MAO-B) inhibitor. MAO-B is a protein in your brain that breaks down dopamine. Low levels of dopamine in your brain cause symptoms of Parkinson’s disease (PD). It’s not fully understood how selegiline works to relieve your PD symptoms. It’s thought that the medication blocks MAO-B to prevent dopamine from being broken down so that dopamine can stay in your brain longer. This helps control your PD symptoms.

How do I take selegiline hydrochloride?

How do I take selegiline hydrochloride?

selegiline hydrochloride is dosed as follows:

  • Regular tablets and capsules: The typical dose is 5 mg by mouth at breakfast and 5 mg at lunch. Don’t take more than 10 mg of selegiline per day. After 2 to 3 days of taking the medication, your provider might prescribe a lower dose of carbidopa/levodopa, depending on how you respond to selegiline
  • Quick-dissolving tablets, also known as orally disintegrating tablets (ODTs): ZELAPAR is the brand name for the ODT form of selegiline. The typical starting dose is 1.25 mg by mouth before breakfast every day for at least 6 weeks. If needed, the dose can be raised to 2.5 mg before breakfast after 6 weeks of taking the starting dose. Don’t take more than 2.5 mg of ZELAPAR per day. Your dose may differ if you have liver problems
Is it safe for me to take selegiline hydrochloride?

Is it safe for me to take selegiline hydrochloride?

selegiline hydrochloride is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you are using the following drugs: opioid drugs (e.g., meperidine, tramadol, methadone), MAO inhibitors including selective MAO-B inhibitors, dextromethorphan, St. John’s wort, and cyclobenzaprine.

selegiline hydrochloride Common Side Effects

selegiline hydrochloride Common Side Effects

Common side effects of selegiline hydrochloride:

  • Nausea
  • Dizziness
  • General body pain
  • Headache
  • Trouble sleeping
  • Runny nose
  • Involuntary movements
  • Skin irritation
  • Back pain
  • Heartburn
  • Inflamed or sore mouth
selegiline hydrochloride Serious Side Effects

selegiline hydrochloride Serious Side Effects

Serious side effects are rare with selegiline hydrochloride. Contact your healthcare provider immediately if you experience any of the following.

  • Serotonin syndrome: Hallucinations, coma, seizures, confusion, restlessness, fainting, shivering, sweating, high fevers, headache, racing heart, high blood pressure, diarrhea, muscle stiffness or twitching, tremor
  • Neuroleptic malignant syndrome (NMS): Very high fevers, irregular pulse, sweating, muscle stiffness, confusion, changes in blood pressure
  • Extremely high blood pressure: Seizures, severe chest pain, severe headache, confusion, blurred vision, anxiety
Effects of other drugs, drug classes and over-the-counter products on selegiline hydrochloride

Effects of other drugs, drug classes and over-the-counter products on selegiline hydrochloride

The following medications may interact with selegiline hydrochloride:

  • Opioid Drugs: Because serious, sometimes fatal reactions have been precipitated with concomitant use of opioid drugs (e.g., meperidine and its derivatives, methadone, or tramadol) and MAOIs, including selective MAO-B inhibitors, concomitant use of these drugs with ZELAPAR is contraindicated. At least 14 days should elapse between discontinuation of ZELAPAR and initiation of treatment with these drugs
  • Dextromethorphan: The combination of MAO inhibitors and dextromethorphan has been reported to cause brief episodes of psychosis or bizarre behavior. Therefore, in view of ZELAPAR’s MAO inhibitory activity, dextromethorphan should not be used concomitantly with ZELAPAR.
  • MAO Inhibitors: ZELAPAR is contraindicated for concomitant use with other drugs in the MAOI class or
  • other drugs that are potent inhibitors of monoamine oxidase (including linezolid, an oxazolidinone antibacterial, which also has reversible nonselective MAO inhibition activity) because of the increased risk for hypertensive crisis. At least 14 days should elapse between discontinuation of ZELAPAR and initiation of treatment with other MAOIs.
  • Sympathomimetic Medications: Uncontrolled hypertension, including hypertensive crisis, has been reported when taking the recommended dose of swallowed selegiline and a sympathomimetic medication
  • Tricyclic Antidepressants and Selective Serotonin Reuptake Inhibitors
  • Severe toxicity has also been reported in patients receiving the combination of tricyclic antidepressants and swallowed selegiline, or selective serotonin reuptake inhibitors and swallowed selegiline
Who makes selegiline hydrochloride?

Who makes selegiline hydrochloride?

Various FDA-approved generic manufacturers

Is selegiline hydrochloride safe in pregnancy?

Is selegiline hydrochloride safe in pregnancy?

selegiline hydrochloride may harm your unborn baby, based on animal data. Tell your healthcare provider if you are pregnant or think you are pregnant.

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What to do if you missed your selegiline hydrochloride dose

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Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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