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Updated on 24 Apr 2024

sacubitril/valsartan Uses, Side Effects, Interactions, Warnings & Dosing

What dosages is sacubitril/valsartan available in?

What dosages is sacubitril/valsartan available in?

sacubitril/valsartan is available as an oral tablet in the following strengths:

  • 24 mg/26 mg
  • 49 mg/51 mg
  • 97 mg/103 mg
What is sacubitril/valsartan used for?

What is sacubitril/valsartan used for?

sacubitril/valsartan is an angiotensin receptor-neprilysin inhibitor (ARNI) and is used to treat heart failure in people ages 1 year or older.

How does sacubitril/valsartan work?

How does sacubitril/valsartan work?

sacubitril/valsartan is a combination of two medications that work together to treat heart failure. Together, they’re known as an angiotensin receptor-neprilysin inhibitor (ARNI). Sacubitril is a neprilysin inhibitor. It works by blocking a protein in your body called neprilysin. This prevents the breakdown of substances called natriuretic peptides. These help relax your blood vessels and lower your blood pressure. They’re important for preventing worsening of heart failure. Valsartan is an angiotensin receptor blocker (ARB). It blocks angiotensin II, a hormone that narrows blood vessels. In doing so, valsartan relaxes blood vessels, which lowers your blood pressure and allows more blood to get to your heart and other organs.

How do I take sacubitril/valsartan?

How do I take sacubitril/valsartan?

sacubitril/valsartan is dosed as follows:


  • The typical starting dose is 49 mg/51 mg (sacubitril/valsartan) by mouth twice a day.
  • Your provider will raise your dose every 2-4 weeks, as needed
  • The typical maintenance dose is 97/103 mg (sacubitril/valsartan) twice a day


  • Your provider will determine your child’s dose based on their body weight. If needed, they’ll adjust your child’s dose every 2 weeks
  • Weight less than 88 lbs: The dose is calculated based on the combined amount of sacubitril and valsartan in the oral liquid. The typical dose starting dose is 1.6 mg/kg by mouth twice daily. The typical maintenance dose is 3.1 mg/kg twice daily
  • Weight 88 lbs to less than 110 lbs: The typical starting dose is 24 mg/26 mg (sacubitril/valsartan) by mouth twice daily. The typical maintenance dose is 72 mg/78 mg (sacubitril/valsartan) twice daily
  • Weight of 110 lbs or more: The typical starting dose is 49 mg/51 mg (sacubitril/valsartan) by mouth twice a day. The typical maintenance dose is 97/103 mg (sacubitril/valsartan) twice a day

Your dose might differ if you have kidney or liver problems, or if you’re not currently taking (or taking a low dose of) an angiotensin-converting enzyme (ACE) inhibitor or ARB.

Is it safe for me to take sacubitril/valsartan?

Is it safe for me to take sacubitril/valsartan?

sacubitril/valsartan is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if any of the following apply:

  • Hypersensitivity to any component
  • History of angioedema related to previous ACEi or ARB therapy
  • Concomitant use with ACE inhibitors
  • Concomitant use with aliskiren in patients with diabetes
sacubitril/valsartan Common Side Effects

sacubitril/valsartan Common Side Effects

Common side effects of sacubitril/valsartan:

  • Low blood pressure
  • High potassium levels
  • Cough
  • Dizziness
  • Kidney problems
sacubitril/valsartan Serious Side Effects

sacubitril/valsartan Serious Side Effects

Serious side effects are rare with sacubitril/valsartan. Contact your healthcare provider immediately if you experience any of the following.

  • Angioedema: swelling of the eyes, face, tongue, throat, hands, feet, legs, or genitals
  • Serious kidney problems: urinating less often than usual, swelling in your feet, ankles, or hands, unexplained weight gain
  • High blood potassium levels: nausea, tiredness, chest pain, muscle weakness, tingling or numbness, pounding heart, nausea
  • Severely low blood pressure: lightheadedness, dizziness, feeling faint, tiredness, confusion
Effects of other drugs, drug classes and over-the-counter products on sacubitril/valsartan

Effects of other drugs, drug classes and over-the-counter products on sacubitril/valsartan

The following medications may interact with sacubitril/valsartan:

  • Avoid concomitant use with aliskiren in patients with eGFR < 60
  • Potassium-sparing diuretics: May lead to increased serum potassium
  • NSAIDs: May lead to increased risk of renal impairment
  • Lithium: Increased risk of lithium toxicity
Who makes sacubitril/valsartan?

Who makes sacubitril/valsartan?

Various FDA-approved generic manufacturers

Is sacubitril/valsartan safe in pregnancy?

Is sacubitril/valsartan safe in pregnancy?

sacubitril/valsartan can harm or cause death to your unborn baby. Talk to your doctor about other ways to treat heart failure if you
plan to become pregnant. If you get pregnant during treatment with sacubitril/valsartan, tell your doctor right away. When pregnancy is detected, discontinue sacubitril/valsartan as soon as possible.


What to do if you missed your sacubitril/valsartan dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

Learn more about reporting side effects
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Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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