How can I lower the cost of my ENTRESTO

You can lower cost of your ENTRESTO using one of the 4 following drug savings programs: Rx Advantage Card for ENTRESTO, Canadian Prescription Savings for ENTRESTO, ENTRESTO Drug Coupons, ENTRESTO Patient Assistance Programs

ENTRESTO Coupon, Savings Card and Patient Assistance

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Are you tired of high medication costs? Our service offers unbeatable savings on your ENTRESTO prescription medication. We provide a range of solutions to help you save up to 100% on your medication costs*. Whether you are insured, uninsured, underinsured, or simply looking to reduce your out-of-pocket expenses, we've got you covered.

Manufactured by Novartis Pharmaceuticals

*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.

This content is intended for US audiences only

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ENTRESTO Uses, Side Effects, Interactions, Warnings & Dosing

Medically reviewed by Jamie Winn, Pharm.D

Written by Rajive Patel, B.Pharm

What is ENTRESTO?

ENTRESTO is the brand name for sacubitril/valsartan and is available as an oral tablet.

What dosages is ENTRESTO available in?

ENTRESTO is available as an oral tablet in the following strengths:

24 mg/26 mg
49 mg/51 mg
97 mg/103 mg

What is ENTRESTO used for?

ENTRESTO is an angiotensin receptor-neprilysin inhibitor (ARNI) and is used to treat heart failure in people ages 1 year or older.

How does ENTRESTO work?

ENTRESTO is a combination of two medications that work together to treat heart failure. Together, they’re known as an angiotensin receptor-neprilysin inhibitor (ARNI). Sacubitril is a neprilysin inhibitor. It works by blocking a protein in your body called neprilysin. This prevents the breakdown of substances called natriuretic peptides. These help relax your blood vessels and lower your blood pressure. They’re important for preventing worsening of heart failure. Valsartan is an angiotensin receptor blocker (ARB). It blocks angiotensin II, a hormone that narrows blood vessels. In doing so, valsartan relaxes blood vessels, which lowers your blood pressure and allows more blood to get to your heart and other organs.

How do I take ENTRESTO?

ENTRESTO is dosed as follows:

Adults:

The typical starting dose is 49 mg/51 mg (sacubitril/valsartan) by mouth twice a day.
Your provider will raise your dose every 2-4 weeks, as needed
The typical maintenance dose is 97/103 mg (sacubitril/valsartan) twice a day

Children:

Your provider will determine your child’s dose based on their body weight. If needed, they’ll adjust your child’s dose every 2 weeks
Weight less than 88 lbs: The dose is calculated based on the combined amount of sacubitril and valsartan in the oral liquid. The typical dose starting dose is 1.6 mg/kg by mouth twice daily. The typical maintenance dose is 3.1 mg/kg twice daily
Weight 88 lbs to less than 110 lbs: The typical starting dose is 24 mg/26 mg (sacubitril/valsartan) by mouth twice daily. The typical maintenance dose is 72 mg/78 mg (sacubitril/valsartan) twice daily
Weight of 110 lbs or more: The typical starting dose is 49 mg/51 mg (sacubitril/valsartan) by mouth twice a day. The typical maintenance dose is 97/103 mg (sacubitril/valsartan) twice a day

Your dose might differ if you have kidney or liver problems, or if you’re not currently taking (or taking a low dose of) an angiotensin-converting enzyme (ACE) inhibitor or ARB.

Is it safe for me to take ENTRESTO?

ENTRESTO is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if any of the following apply:

Hypersensitivity to any component
History of angioedema related to previous ACEi or ARB therapy
Concomitant use with ACE inhibitors
Concomitant use with aliskiren in patients with diabetes

ENTRESTO Common Side Effects

Common side effects of ENTRESTO:

Low blood pressure
High potassium levels
Cough
Dizziness
Kidney problems

ENTRESTO Serious Side Effects

Serious side effects are rare with ENTRESTO. Contact your healthcare provider immediately if you experience any of the following.

Angioedema: swelling of the eyes, face, tongue, throat, hands, feet, legs, or genitals
Serious kidney problems: urinating less often than usual, swelling in your feet, ankles, or hands, unexplained weight gain
High blood potassium levels: nausea, tiredness, chest pain, muscle weakness, tingling or numbness, pounding heart, nausea
Severely low blood pressure: lightheadedness, dizziness, feeling faint, tiredness, confusion

Effects of other drugs, drug classes and over-the-counter products on ENTRESTO

The following medications may interact with ENTRESTO:

Avoid concomitant use with aliskiren in patients with eGFR < 60
Potassium-sparing diuretics: May lead to increased serum potassium
NSAIDs: May lead to increased risk of renal impairment
Lithium: Increased risk of lithium toxicity

Who makes ENTRESTO?

Novartis Pharmaceuticals

Is ENTRESTO safe in pregnancy?

ENTRESTO can harm or cause death to your unborn baby. Talk to your doctor about other ways to treat heart failure if you
plan to become pregnant. If you get pregnant during treatment with ENTRESTO, tell your doctor right away. When pregnancy is detected, discontinue ENTRESTO as soon as possible.

What is the generic name for ENTRESTO?

sacubitril/valsartan

The FDA's medical product safety reporting program for health professionals, patients and consumers.

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Drug Savings Tips

How can NowPatient help me to lower the cost of my ENTRESTO prescription?

How do the NowPatient ENTRESTO savings programs work?

Are the NowPatient ENTRESTO savings programs suitable for everyone, regardless of insurance status?

	Rx Advantage Card* for ENTRESTO	Canadian Prescription Savings* for ENTRESTO	ENTRESTO Drug Coupon*	ENTRESTO Patient Assistance Program*
Insured (federal, state or government)	Available	Available	Not Available	Available If Offered by Pharmaceutical Company
Insured (Commercial or Private)	Available	Available	Available If Offered by Pharmaceutical Company	Available If Offered by Pharmaceutical Company
Uninsured	Available	Available	Not Available	Available If Offered by Pharmaceutical Company
Insured but without pharmacy benefit or drug coverage	Available	Available	Not Available	Available If Offered by Pharmaceutical Company

Are the NowPatient drug savings programs suitable for brand and generic versions of ENTRESTO?

	Rx Advantage Card* for ENTRESTO	Canadian Prescription Savings* for ENTRESTO	ENTRESTO Drug Coupon*	ENTRESTO Patient Assistance Program*
Brand	Yes	Yes	Yes, If Offered by Pharmaceutical Company	Yes, If Offered by Pharmaceutical Company
Generic	Yes	Yes	No	No

If you have Medicare Part D or Medicare Advantage and none of the ENTRESTO savings options are applicable or affordable for me, what can you do?

I am uninsured or underinsured and none of the ENTRESTO prescription saving options are applicable or affordable for me, what can I do?

I am commercially or privately insured and none of the ENTRESTO prescription saving options are applicable or affordable for me, what can I do?

If I have federal, state or commercial insurance and none of the ENTRESTO prescription saving options are applicable or affordable for me, are there any other support organisations that can help me with my co-insurance or copay?

If you have already tried Medicaid and received a denial letter or if you are insured with Medicare and have been denied Low-Income Subsidy, then you can try one of the following organizational support programs:

1. Patient Access Network Foundation (PAN) assistance for ENTRESTO

If you are having trouble paying for your ENTRESTO medication due to unaffordable copays or deductibles, the Patient Access Network Foundation (PAN), may be able to assist you. To qualify for PAN assistance for ENTRESTO you will need to meet one or all of the following criteria:

Your income is below 400% of the federal poverty level
ENTRESTO is prescribed for an approved FDA indication
You live in and receive treatment in the United States or U.S. territories, even if you do not have U.S. citizenship
You have Medicare insurance coverage that covers ENTRESTO
If ENTRESTO is listed on PAN’s list of covered medications

You can check the Patient Access Network Foundation Website for more information.

2. HealthWell Foundation Copay Program for ENTRESTO

If you are having trouble paying for your ENTRESTO medication due to unaffordable copays or deductibles, the HealthWell Foundation Copay Program may be able to assist you. To qualify for assistance for ENTRESTO you will need to meet the following criteria:

You live in and are being treated in the United States
You are insured and your plan covers ENTRESTO
If ENTRESTO is listed on the HealthWell Foundation’s list of covered medications

You can check the HealthWell Foundation Website for more information.

3. Patient Advocate Foundation Co-Pay Relief Program for ENTRESTO

Patient Advocate Foundation’s Co-Pay Relief program exists to help reduce the financial distress you or your family may face when paying for your ENTRESTO treatment. If you qualify and can demonstrate the need, the foundation will provide you with direct payment covering co-pays, co-insurance, and deductibles. To qualify for assistance for ENTRESTO you will need to meet the following criteria:

You must be currently insured and have coverage for ENTRESTO
You must have a confirmed diagnosis and treatment plan
You must reside and receive treatment in the United States
Your Income must fall at or below 300% or 400% of the Federal Poverty Guideline (FPG) with consideration for the Cost of Living Index (COLI) and number in the household
Applications can also be completed by contacting the program sponsor, toll-free at 866-512-3861.

You can check the Patient Advocate Foundation Website for more information.

Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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