ENTRESTO
Are you tired of high medication costs? Our service offers unbeatable savings on your ENTRESTO prescription medication. We provide a range of solutions to help you save up to 100% on your medication costs*. Whether you are insured, uninsured, underinsured, or simply looking to reduce your out-of-pocket expenses, we've got you covered.
Manufactured by Novartis Pharmaceuticals
*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.
This content is intended for US audiences only
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ENTRESTO key facts
What is ENTRESTO?
ENTRESTO is the brand name for sacubitril/valsartan and is available as an oral tablet.
What dosages is ENTRESTO available in?
ENTRESTO is available as an oral tablet in the following strengths:
- 24 mg/26 mg
- 49 mg/51 mg
- 97 mg/103 mg
What is ENTRESTO used for?
ENTRESTO is an angiotensin receptor-neprilysin inhibitor (ARNI) and is used to treat heart failure in people ages 1 year or older.
How does ENTRESTO work?
ENTRESTO is a combination of two medications that work together to treat heart failure. Together, they’re known as an angiotensin receptor-neprilysin inhibitor (ARNI). Sacubitril is a neprilysin inhibitor. It works by blocking a protein in your body called neprilysin. This prevents the breakdown of substances called natriuretic peptides. These help relax your blood vessels and lower your blood pressure. They’re important for preventing worsening of heart failure. Valsartan is an angiotensin receptor blocker (ARB). It blocks angiotensin II, a hormone that narrows blood vessels. In doing so, valsartan relaxes blood vessels, which lowers your blood pressure and allows more blood to get to your heart and other organs.
How do I take ENTRESTO?
ENTRESTO is dosed as follows:
Adults:
- The typical starting dose is 49 mg/51 mg (sacubitril/valsartan) by mouth twice a day.
- Your provider will raise your dose every 2-4 weeks, as needed
- The typical maintenance dose is 97/103 mg (sacubitril/valsartan) twice a day
Children:
- Your provider will determine your child’s dose based on their body weight. If needed, they’ll adjust your child’s dose every 2 weeks
- Weight less than 88 lbs: The dose is calculated based on the combined amount of sacubitril and valsartan in the oral liquid. The typical dose starting dose is 1.6 mg/kg by mouth twice daily. The typical maintenance dose is 3.1 mg/kg twice daily
- Weight 88 lbs to less than 110 lbs: The typical starting dose is 24 mg/26 mg (sacubitril/valsartan) by mouth twice daily. The typical maintenance dose is 72 mg/78 mg (sacubitril/valsartan) twice daily
- Weight of 110 lbs or more: The typical starting dose is 49 mg/51 mg (sacubitril/valsartan) by mouth twice a day. The typical maintenance dose is 97/103 mg (sacubitril/valsartan) twice a day
Your dose might differ if you have kidney or liver problems, or if you’re not currently taking (or taking a low dose of) an angiotensin-converting enzyme (ACE) inhibitor or ARB.
Is it safe for me to take ENTRESTO?
ENTRESTO is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if any of the following apply:
- Hypersensitivity to any component
- History of angioedema related to previous ACEi or ARB therapy
- Concomitant use with ACE inhibitors
- Concomitant use with aliskiren in patients with diabetes
ENTRESTO Common Side Effects
Common side effects of ENTRESTO:
- Low blood pressure
- High potassium levels
- Cough
- Dizziness
- Kidney problems
ENTRESTO Serious Side Effects
Serious side effects are rare with ENTRESTO. Contact your healthcare provider immediately if you experience any of the following.
- Angioedema: swelling of the eyes, face, tongue, throat, hands, feet, legs, or genitals
- Serious kidney problems: urinating less often than usual, swelling in your feet, ankles, or hands, unexplained weight gain
- High blood potassium levels: nausea, tiredness, chest pain, muscle weakness, tingling or numbness, pounding heart, nausea
- Severely low blood pressure: lightheadedness, dizziness, feeling faint, tiredness, confusion
Effects of other drugs, drug classes and over-the-counter products on ENTRESTO
The following medications may interact with ENTRESTO:
- Avoid concomitant use with aliskiren in patients with eGFR < 60
- Potassium-sparing diuretics: May lead to increased serum potassium
- NSAIDs: May lead to increased risk of renal impairment
- Lithium: Increased risk of lithium toxicity
Who makes ENTRESTO?
Novartis Pharmaceuticals
Is ENTRESTO safe in pregnancy?
ENTRESTO can harm or cause death to your unborn baby. Talk to your doctor about other ways to treat heart failure if you
plan to become pregnant. If you get pregnant during treatment with ENTRESTO, tell your doctor right away. When pregnancy is detected, discontinue ENTRESTO as soon as possible.
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effectsDrug Savings Guide
A practical guide to saving money and receiving support with prescription costs
How can NowPatient help me to lower the cost of my ENTRESTO prescription?
After you create a FREE account with NowPatient, you will have access to 4 programs that can help lower the cost of your ENTRESTO prescription
Applicability to each program will be dependent on your insurance status.
How do the NowPatient ENTRESTO savings programs work?
After you have created your FREE account with NowPatient, you can access the various programs from your account dashboard. Each program has clear instructions on how to check your eligibility. You can see how the process works by clicking on the feature link below and seeing the ‘How it works’ steps.
Drug Coupon and Patient Assistance Programs require an eligibility quiz to be completed.
Are the NowPatient ENTRESTO savings programs suitable for everyone, regardless of insurance status?
No. Each program has its own eligibility and applicability requirements. The table below shows if a program is available to you, based on your insurance status.
| Rx Advantage Card* for ENTRESTO | Canadian Prescription Savings* for ENTRESTO | ENTRESTO Drug Coupon* | ENTRESTO Patient Assistance Program* | |
| Insured (federal, state or government) | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured (Commercial or Private) | Available | Available | Available If Offered by Pharmaceutical Company | Available If Offered by Pharmaceutical Company |
| Uninsured | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured but without pharmacy benefit or drug coverage | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
*This is not insurance.
Are the NowPatient drug savings programs suitable for brand and generic versions of ENTRESTO?
No. Each program has applicability requirements. Please see below
| Rx Advantage Card* for ENTRESTO | Canadian Prescription Savings* for ENTRESTO | ENTRESTO Drug Coupon* | ENTRESTO Patient Assistance Program* | |
| Brand | Yes | Yes | Yes, If Offered by Pharmaceutical Company | Yes, If Offered by Pharmaceutical Company |
| Generic | Yes | Yes | No | No |
*This is not insurance.
If you have Medicare Part D or Medicare Advantage and none of the ENTRESTO savings options are applicable or affordable for me, what can you do?
If you are insured with Medicare and the ENTRESTO drug savings options are not applicable to you and still remain unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and after you have selected your state, it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
People who qualify for both Medicare and Medicaid are called ‘dual eligibles’.
If you are denied Medicaid for ENTRESTO, and you are still unable to afford your copay or co-insurance element (for example if you are in the coverage gap or Donut Hole) then you may be eligible for a federal support program like Low Income Subsidy. To be eligible for Low Income Subsidy, you need to be a resident in one of the 50 States or the District of Columbia. You can check eligibility online at SSA Medicare D Extra Help. You can also call Social Security at 1-800-772-1213 (TTY 1-800-325-0778).
I am uninsured or underinsured and none of the ENTRESTO prescription saving options are applicable or affordable for me, what can I do?
If you are uninsured or underinsured (for example, ENTRESTO is not covered by your plan) and the drug savings options are not applicable or still unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
If you are denied and all else fails, and if you have been prescribed ENTRESTO for an FDA-approved indication, you can call the pharmaceutical company to see if they have any other assistance programs.
I am commercially or privately insured and none of the ENTRESTO prescription saving options are applicable or affordable for me, what can I do?
If your medication is not covered by your plan, you can you can appeal your insurance company’s decision. Sometimes, a formal appeal can result in the drug being covered if it is deemed medically necessary.
If you cannot afford your copay, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
However, being privately insured might complicate your eligibility for Medicaid, as having private insurance may be considered in the financial eligibility assessment.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. If you qualify, state Medicaid may cover the full cost of your medication.
If I have federal, state or commercial insurance and none of the ENTRESTO prescription saving options are applicable or affordable for me, are there any other support organisations that can help me with my co-insurance or copay?
If you have already tried Medicaid and received a denial letter or if you are insured with Medicare and have been denied Low-Income Subsidy, then you can try one of the following organizational support programs:
1. Patient Access Network Foundation (PAN) assistance for ENTRESTO
If you are having trouble paying for your ENTRESTO medication due to unaffordable copays or deductibles, the Patient Access Network Foundation (PAN), may be able to assist you. To qualify for PAN assistance for ENTRESTO you will need to meet one or all of the following criteria:
- Your income is below 400% of the federal poverty level
- ENTRESTO is prescribed for an approved FDA indication
- You live in and receive treatment in the United States or U.S. territories, even if you do not have U.S. citizenship
- You have Medicare insurance coverage that covers ENTRESTO
- If ENTRESTO is listed on PAN’s list of covered medications
You can check the Patient Access Network Foundation Website for more information.
2. HealthWell Foundation Copay Program for ENTRESTO
If you are having trouble paying for your ENTRESTO medication due to unaffordable copays or deductibles, the HealthWell Foundation Copay Program may be able to assist you. To qualify for assistance for ENTRESTO you will need to meet the following criteria:
- You live in and are being treated in the United States
- You are insured and your plan covers ENTRESTO
- If ENTRESTO is listed on the HealthWell Foundation’s list of covered medications
You can check the HealthWell Foundation Website for more information.
3. Patient Advocate Foundation Co-Pay Relief Program for ENTRESTO
Patient Advocate Foundation’s Co-Pay Relief program exists to help reduce the financial distress you or your family may face when paying for your ENTRESTO treatment. If you qualify and can demonstrate the need, the foundation will provide you with direct payment covering co-pays, co-insurance, and deductibles. To qualify for assistance for ENTRESTO you will need to meet the following criteria:
- You must be currently insured and have coverage for ENTRESTO
- You must have a confirmed diagnosis and treatment plan
- You must reside and receive treatment in the United States
- Your Income must fall at or below 300% or 400% of the Federal Poverty Guideline (FPG) with consideration for the Cost of Living Index (COLI) and number in the household
- Applications can also be completed by contacting the program sponsor, toll-free at 866-512-3861.
You can check the Patient Advocate Foundation Website for more information.
Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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