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Rivaroxaban is available as a 2.5 mg, 10 mg, 15 mg, and 20 mg oral tablet and a 1 mg/ml oral suspension.

Rivaroxaban is a direct-acting oral anticoagulant (DOAC) and is used for the following:

• Lowering the risk of stroke and blood clots in with atrial fibrillation (AFib) that isn’t caused by a heart valve problem
• Treating blood clots in the legs (deep vein thrombosis (DVT)) or lungs (pulmonary embolism (PE))
• Lowering the risk of blood clots from happening again in the legs (DVT) or lungs (PE) in certain people who are at high risk for clots
• Preventing blood clots in the legs (DVT) or lungs (PE) in people who’ve had recent hip or knee surgery, those who are hospitalized, or those who were recently released from the hospital and are at high risk for blood clots
• Lowering the risk of serious heart-related problems, such as heart attack or stroke, in people with coronary artery disease (CAD) when used together with aspirin
• Lowering the risk of blood flow issues, major amputations, serious heart problems, or stroke in people with peripheral artery disease (PAD) when used together with aspirin
• Treating blood clots and lowering the risk of blood clots from happening again after receiving at least 5 days of treatment with injectable blood thinner medications
  Preventing blood clots in children ages 2 and older with a congenital heart disease (CHD) after a Fontan procedure

Rivaroxaban is a direct-acting oral anticoagulant (DOAC) that works by stopping factor Xa, a protein that’s involved in the blood clotting process. When this protein is blocked, blood clots are less likely to form in your body. Rivaroxaban can either treat or prevent these dangerous blood clots from forming, especially in people who are at higher risk for them.

Rivaroxaban is dosed as follows:

Adults:

• The dose and length of treatment for Rivaroxaban will vary depending on your condition. Your dose might be lower if you have kidney problems
• Lowering the risk of a stroke in AFib: The typical dose is 20 mg by mouth once a day in the evening
• Treating DVT or PE: The typical dose is to start with 15 mg by mouth twice a day for 21 days, then switch to 20 mg once a day
• Lowering the risk of DVT or PE: The typical dose is 10 mg by mouth once a day, for at least 6 months with anticoagulant treatment
• Preventing DVT or PE in people with recent surgery or hospitalization:
• Hip replacement surgery: The typical dose is 10 mg by mouth once a day for 35 days.
• Knee replacement surgery: The typical dose is 10 mg by mouth once a day for 12 days.
• Hospitalization: The typical dose is 10 mg by mouth once a day starting in the hospital and continuing after discharge for a total of 31 to 39 days.
• Lowering the risk of serious heart-related problems in CAD and PAD: The typical dose is 2.5 mg twice daily by mouth, plus aspirin (75 to 100 mg) once a day by mouth.

Children:

• The dose is based on your child’s weight. Depending on your child’s weight and the condition that the medication is being used for, the dose is taken by mouth ranging from 1 to 3 times a day

Rivaroxaban is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:

• Active pathological bleeding
• Severe hypersensitivity reaction to Rivaroxaban

Common side effects of Rivaroxaban:

• Any bleeding
• Cough
• Vomiting
• Stomach virus
• Rash

Serious side effects are rare with Rivaroxaban. Contact your healthcare provider immediately if you experience any of the following.

• Serious bleeding: black, red, or tarry stools, urine in the blood, vomiting blood, unexplained bruises, bruises that get bigger, bleeding that won’t stop
• Bleeding around the spine (spinal or epidural hematoma): back pain, weakness, difficulty walking, loss of bowel or bladder control, paralysis

The following medications may interact with Rivaroxaban:

• Avoid combined P-gp and strong CYP3A inhibitors and inducers
• Anticoagulants: Avoid concomitant use

Various FDA-approved generic manufacturers

It is not known if Rivaroxaban will harm your unborn baby. If you take Rivaroxaban during pregnancy tell your doctor right away if you have any signs or symptoms of bleeding or blood loss.

• Xarelto