rituximab-pvvr
Used for Cancer
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Manufactured by various FDA-approved generic manufacturers.
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rituximab-pvvr Uses, Side Effects, Interactions, Warnings & Dosing
What dosages is rituximab-pvvr available in?
rituximab-pvvr is available as a 100 mg/10 mL (10 mg/mL) and 500 mg/50 mL (10 mg/mL) solution for an IV infusion.
What is rituximab-pvvr used for?
rituximab-pvvr is a monoclonal antibody that is used for the following:
Blood cancers
- Certain types of CD20-positive non-Hodgkin’s lymphoma (NHL) in adults and children ages 6 months and older
- CD20-positive chronic lymphocytic leukemia (CLL) in adults
Autoimmune conditions
- Moderate to severe rheumatoid arthritis (RA) in adults
Granulomatosis with polyangitis (GPA) and microscopic polyangitis (MPA) in adults and children ages 2 years and older - Moderate to severe pemphigus vulgaris in adults
How does rituximab-pvvr work?
rituximab-pvvr is a monoclonal antibody. It targets specific immune cells called B cells that can be involved in a range of different health conditions. For example, B cells sometimes turn into cancer cells. Other times, they become overly active and cause autoimmune conditions.
How do I take rituximab-pvvr?
rituximab-pvvr is dosed as follows: Your provider will determine your dose of rituximab-pvvr based on your body surface area (BSA) in m². This medication is typically given by a healthcare provider in a hospital or infusion clinic setting. Your provider might also give you other anticancer medications along with rituximab-pvvr.
Non-Hodgkin’s lymphoma
- Adults: The typical dose is 375 mg/m² given as an intravenous infusion. How often you’ll receive a dose usually ranges from weekly to every 8 weeks, depending on the type of NHL you have and where you are in the treatment process.
Children: Talk with your child’s provider.
- Chronic Lymphocytic Leukemia (CLL)
- Adults: The typical dose is to receive one 375 mg/m² intravenous infusion before the start of chemotherapy. Then, your provider will raise your dose to 500 mg/m² infused on Day 1 of a 28-day chemotherapy cycle, for 2 to 6 cycles.
Autoimmune conditions
- Your provider might also give you other medications along with rituximab-pvvr to treat your condition.
RA
- Adults: The typical starting dose is 1,000 mg infused IV for 2 doses, given 2 weeks apart. The typical maintenance dose is 1,000 mg infused once every 4 to 6 months, depending on your condition.
GPA and MPA
- Adults: Your provider will determine your dose of rituximab-pvvr based on your body surface area (BSA) in m². The typical starting dose is 375 mg/m² given as an intravenous infusion weekly for 4 weeks. The typical maintenance dose is 250 mg/m², usually infused once every 6 months.
Children: Ask your child’s provider.
- PV
- Adults: The typical starting dose is 1,000 mg infused IV for 2 doses, given 2 weeks apart. The typical maintenance dose is 500 mg infused a year after the starting dose, then once every 6 months.
Is it safe for me to take rituximab-pvvr?
rituximab-pvvr is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.
rituximab-pvvr Common Side Effects
Common side effects of rituximab-pvvr:
- Fever
- Lower white blood cell counts
- Chills
- Infection
- Weakness
- Nausea
- Headache
- Night sweats
- Rash
rituximab-pvvr Serious Side Effects
Serious side effects are rare with rituximab-pvvr. Contact your healthcare provider immediately if you experience any of the following.
- Infusion-related reaction: swelling, trouble breathing, chest pain, low blood pressure, red skin
- Serious skin reaction: painful blisters, skin wounds, peeling skin, fever, sore throat, body aches
- Tears in the gut: sudden and severe stomach pain, fever, chills, and nausea or vomiting that won’t go away
- Infection: fever, chills, cough, muscle aches, very fast heartbeat, severe tiredness
- Tumor lysis syndrome: seizures, hallucinations, nausea, tiredness, no appetite, dark-colored urine, muscle
- cramps, numbness
Serious heart problems: tiredness, weakness, dizziness, feeling faint, trouble breathing, pressure on the chest, pounding heart, irregular heart beat, sweating, feeling anxious, nausea
Effects of other drugs, drug classes and over-the-counter products on rituximab-pvvr
The following medications may interact with rituximab-pvvr:
- Renal toxicity when used in combination with cisplatin
Who makes rituximab-pvvr?
Various FDA-approved generic manufacturers
Is rituximab-pvvr safe in pregnancy?
Talk to your healthcare provider about the risks to your unborn baby if you receive rituximab-pvvr during pregnancy.
Females who are able to become pregnant:
- Your healthcare provider should do a pregnancy test to see if you are pregnant before starting rituximab-pvvr
- You should use effective birth control (contraception) during treatment with rituximab-pvvr and for 12 months after your last dose of rituximab-pvvr. Talk to your healthcare provider about effective birth control
- Tell your healthcare provider right away if you become pregnant or think that you are pregnant during treatment with rituximab-pvvr
What to do if you missed your rituximab-pvvr dose
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Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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