ranolazine
Used for Unstable Angina
NowPatient helps you obtain your ranolazine prescription for free or at low-cost. Drug savings programs are suitable for individuals who are insured, don't have insurance or are underinsured and can't afford your medicine.
Manufactured by various FDA-approved generic manufacturers.
*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.
This content is intended for US audiences only
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ranolazine key facts
What dosages is ranolazine available in?
ranolazine is available as a 500 mg and 1000 mg oral tablet.
What is ranolazine used for?
ranolazine is an antianginal that is used to treat a certain type of long-term chest pain (chronic angina).
How does ranolazine work?
ranolazine is an antianginal medication. Angina (chest pain) happens when the heart muscle isn’t getting enough oxygen. The way ranolazine works to treat angina isn’t completely understood. But it’s thought to help your heart work more efficiently by changing the flow of electrolytes in the heart. This might help lower the symptoms of angina.
How do I take ranolazine?
ranolazine is typically started at 500 mg by mouth twice a day. Your provider may raise the dose to a maximum of 1,000 mg twice a day, based on how you respond to the medication.
Is it safe for me to take ranolazine?
ranolazine is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have liver cirrhosis or are taking a strong CYP3A inhibitor (e.g., ketoconazole, clarithromycin, lovastatin) or a CYP3A inducer (e.g., rifampin, phenobarbital, St. John’s wort).
ranolazine Common Side Effects
Common side effects of ranolazine:
- Dizziness
- Headache
- Constipation
- Nausea
- Palpitations (racing heart)
- Dry mouth
ranolazine Serious Side Effects
Serious side effects are rare with ranolazine. Contact your healthcare provider immediately if you experience any of the following.
- Abnormal heart rhythm: abnormal heart rate, dizziness, difficulty breathing, chest pain, fainting
- Serious kidney problems: tiredness, blood or foam in your urine, urinating more often, muscle cramping, swollen feet or ankles, poor appetite
Effects of other drugs, drug classes and over-the-counter products on ranolazine
The following medications may interact with ranolazine:
- CYP3A inhibitors: Do not use ranolazine with strong CYP3A inhibitors. With moderate 3A inhibitors (e.g., diltiazem
- verapamil, erythromycin), limit maximum dose of ranolazine to 500 mg twice daily.
- CYP3A inducers: Do not use ranolazine with CYP3A inducers
- P-gp inhibitors (e.g., cyclosporine): May need to lower ranolazine dose based on clinical response
- Drugs transported by P-gp or metabolized by CYP2D6 (e.g., digoxin, tricyclic antidepressants): May need reduced doses of these drugs when used with ranolazine.
Who makes ranolazine?
Various FDA-approved generic manufacturers
Is ranolazine safe in pregnancy?
There are no adequate well-controlled studies of ranolazine use in pregnant women. ranolazine should be used during pregnancy only when the potential benefit to the patient justifies the potential risk to the fetus.
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effects in the USDrug Savings Guide
A practical guide to saving money and receiving support with prescription costs
How can NowPatient help me to lower the cost of my ranolazine prescription?
After you create a FREE account with NowPatient, you will have access to 4 programs that can help lower the cost of your ranolazine prescription
Applicability to each program will be dependent on your insurance status.
How do the NowPatient ranolazine savings programs work?
After you have created your FREE account with NowPatient, you can access the various programs from your account dashboard. Each program has clear instructions on how to check your eligibility. You can see how the process works by clicking on the feature link below and seeing the ‘How it works’ steps.
Drug Coupon and Patient Assistance Programs require an eligibility quiz to be completed.
Are the NowPatient ranolazine savings programs suitable for everyone, regardless of insurance status?
No. Each program has its own eligibility and applicability requirements. The table below shows if a program is available to you, based on your insurance status.
| Rx Advantage Card* for ranolazine | Canadian Prescription Savings* for ranolazine | ranolazine Drug Coupon* | ranolazine Patient Assistance Program* | |
| Insured (federal, state or government) | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured (Commercial or Private) | Available | Available | Available If Offered by Pharmaceutical Company | Available If Offered by Pharmaceutical Company |
| Uninsured | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured but without pharmacy benefit or drug coverage | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
*This is not insurance.
Are the NowPatient drug savings programs suitable for brand and generic versions of ranolazine?
No. Each program has applicability requirements. Please see below
| Rx Advantage Card* for ranolazine | Canadian Prescription Savings* for ranolazine | ranolazine Drug Coupon* | ranolazine Patient Assistance Program* | |
| Brand | Yes | Yes | Yes, If Offered by Pharmaceutical Company | Yes, If Offered by Pharmaceutical Company |
| Generic | Yes | Yes | No | No |
*This is not insurance.
If you have Medicare Part D or Medicare Advantage and none of the ranolazine savings options are applicable or affordable for me, what can you do?
If you are insured with Medicare and the ranolazine drug savings options are not applicable to you and still remain unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and after you have selected your state, it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
People who qualify for both Medicare and Medicaid are called ‘dual eligibles’.
If you are denied Medicaid for ranolazine, and you are still unable to afford your copay or co-insurance element (for example if you are in the coverage gap or Donut Hole) then you may be eligible for a federal support program like Low Income Subsidy. To be eligible for Low Income Subsidy, you need to be a resident in one of the 50 States or the District of Columbia. You can check eligibility online at SSA Medicare D Extra Help. You can also call Social Security at 1-800-772-1213 (TTY 1-800-325-0778).
I am uninsured or underinsured and none of the ranolazine prescription saving options are applicable or affordable for me, what can I do?
If you are uninsured or underinsured (for example, ranolazine is not covered by your plan) and the drug savings options are not applicable or still unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
If you are denied and all else fails, and if you have been prescribed ranolazine for an FDA-approved indication, you can call the pharmaceutical company to see if they have any other assistance programs.
I am commercially or privately insured and none of the ranolazine prescription saving options are applicable or affordable for me, what can I do?
If your medication is not covered by your plan, you can appeal your insurance company’s decision. Sometimes, a formal appeal can result in the drug being covered if it is deemed medically necessary.
If you cannot afford your copay contribution, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
However, being privately insured might complicate your eligibility for Medicaid, as having private insurance may be considered in the financial eligibility assessment.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. If you qualify, state Medicaid may cover the full cost of your medication.
If I have federal, state or commercial insurance and none of the ranolazine prescription saving options are applicable or affordable for me, are there any other support organisations that can help me with my co-insurance or copay contributions?
If you have already tried Medicaid and received a denial letter or if you are insured with Medicare and have been denied Low-Income Subsidy, then you can try one of the following organizational support programs:
1. Patient Access Network Foundation (PAN) assistance for ranolazine
If you are having trouble paying for your ranolazine medication due to unaffordable copays or deductibles, the Patient Access Network Foundation (PAN), may be able to assist you. To qualify for PAN assistance for ranolazine you will need to meet one or all of the following criteria:
- Your income is below 400% of the federal poverty level
- ranolazine is prescribed for an approved FDA indication
- You live in and receive treatment in the United States or U.S. territories, even if you do not have U.S. citizenship
- You have Medicare insurance coverage that covers ranolazine
- If ranolazine is listed on PAN’s list of covered medications
You can check the Patient Access Network Foundation Website for more information.
2. HealthWell Foundation Copay Program for ranolazine
If you are having trouble paying for your ranolazine medication due to unaffordable copays or deductibles, the HealthWell Foundation Copay Program may be able to assist you. To qualify for assistance for ranolazine you will need to meet the following criteria:
- You live in and are being treated in the United States
- You are insured and your plan covers ranolazine
- If ranolazine is listed on the HealthWell Foundation’s list of covered medications
You can check the HealthWell Foundation Website for more information.
3. Patient Advocate Foundation Co-Pay Relief Program for ranolazine
Patient Advocate Foundation’s Co-Pay Relief program exists to help reduce the financial distress you or your family may face when paying for your ranolazine treatment. If you qualify and can demonstrate the need, the foundation will provide you with direct payment covering co-pays, co-insurance, and deductibles. To qualify for assistance for ranolazine you will need to meet the following criteria:
- You must be currently insured and have coverage for ranolazine
- You must have a confirmed diagnosis and treatment plan
- You must reside and receive treatment in the United States
- Your Income must fall at or below 300% or 400% of the Federal Poverty Guideline (FPG) with consideration for the Cost of Living Index (COLI) and number in the household
- Applications can also be completed by contacting the program sponsor, toll-free at 866-512-3861.
You can check the Patient Advocate Foundation Website for more information.
Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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