ranolazine
Used for Unstable Angina
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Manufactured by various FDA-approved generic manufacturers.
*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.
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ranolazine Uses, Side Effects, Interactions, Warnings & Dosing
What dosages is ranolazine available in?
ranolazine is available as a 500 mg and 1000 mg oral tablet.
What is ranolazine used for?
ranolazine is an antianginal that is used to treat a certain type of long-term chest pain (chronic angina).
How does ranolazine work?
ranolazine is an antianginal medication. Angina (chest pain) happens when the heart muscle isn’t getting enough oxygen. The way ranolazine works to treat angina isn’t completely understood. But it’s thought to help your heart work more efficiently by changing the flow of electrolytes in the heart. This might help lower the symptoms of angina.
How do I take ranolazine?
ranolazine is typically started at 500 mg by mouth twice a day. Your provider may raise the dose to a maximum of 1,000 mg twice a day, based on how you respond to the medication.
Is it safe for me to take ranolazine?
ranolazine is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have liver cirrhosis or are taking a strong CYP3A inhibitor (e.g., ketoconazole, clarithromycin, lovastatin) or a CYP3A inducer (e.g., rifampin, phenobarbital, St. John’s wort).
ranolazine Common Side Effects
Common side effects of ranolazine:
- Dizziness
- Headache
- Constipation
- Nausea
- Palpitations (racing heart)
- Dry mouth
ranolazine Serious Side Effects
Serious side effects are rare with ranolazine. Contact your healthcare provider immediately if you experience any of the following.
- Abnormal heart rhythm: abnormal heart rate, dizziness, difficulty breathing, chest pain, fainting
- Serious kidney problems: tiredness, blood or foam in your urine, urinating more often, muscle cramping, swollen feet or ankles, poor appetite
Effects of other drugs, drug classes and over-the-counter products on ranolazine
The following medications may interact with ranolazine:
- CYP3A inhibitors: Do not use ranolazine with strong CYP3A inhibitors. With moderate 3A inhibitors (e.g., diltiazem
- verapamil, erythromycin), limit maximum dose of ranolazine to 500 mg twice daily.
- CYP3A inducers: Do not use ranolazine with CYP3A inducers
- P-gp inhibitors (e.g., cyclosporine): May need to lower ranolazine dose based on clinical response
- Drugs transported by P-gp or metabolized by CYP2D6 (e.g., digoxin, tricyclic antidepressants): May need reduced doses of these drugs when used with ranolazine.
Who makes ranolazine?
Various FDA-approved generic manufacturers
Is ranolazine safe in pregnancy?
There are no adequate well-controlled studies of ranolazine use in pregnant women. ranolazine should be used during pregnancy only when the potential benefit to the patient justifies the potential risk to the fetus.
The FDA's medical product safety reporting program for health professionals, patients and consumers.
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Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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