RanolazinePrices, Coupons & Savings

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*Based on the difference between the U&C price submitted and the price the patient paid, as of April 2023.

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  2. Ranolazine Extended Release (ER)
    Generic for Ranexa
    30 extended release tablets $6.9 USD
    Save $155.10
  3. Ranolazine Extended Release (ER)
    Generic for Ranexa
    45 extended release tablets $9 USD
    Save $234.00
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Do you need a prescription for ranolazine?

Yes, ranolazine is only available with a valid physician Rx.

How much is ranolazine without Insurance in the US?

Our website gives two competitive savings options to US customers who wish to purchase ranolazine, as either a brand or generic, if available. The first is access to medications through our mail-order online pharmacy. The second is by using the Now Patient Rx Advantage Card, which can be used in over 65,000 pharmacies nationwide, across America. If you are insured, then in most cases, the cash price will be significantly cheaper than the copay.

What will my out-of-pocket cost be for ranolazine in the US?

There are no out-of-pocket (OOP) costs because we are currently only offering a cash-based option to purchase medications.

Is Now Patient a ranolazine savings card?

Yes. Save up to 90% on your ranolazine with the FREE Now Patient Rx Advantage card*.
*Based on the difference between the U&C submitted by the pharmacy and the price the patients pay.

Can you handle Rx transfers for home delivery in the US?

Yes. If you use the mail-order online pharmacy option, then we can handle requests by you to have your prescription transferred to our pharmacy for home delivery. We can even help you manage your refills by giving you timely reminders, so you do not run out of your medication.

Is Now Patient a ranolazine coupon provider in the US?

No. Now Patient does not provide ranolazine coupons or FREE ranolazine samples.

Do you accept commercial, Medicare or Medicaid coverage for ranolazine in the US?

No. Currently, we only offer cash-based options for purchase, therefore we do not require your insurance benefit details. In the future, our plan is to be able to handle commercial insurance, Medicare and Medicaid including cases where you have multiple health plans that provide benefit coverage (e.g. Medicaid and Commercial). We also anticipate being able to handle more complex scenarios such as using primary insurance combined with a manufacturer copay assistance program.

Does Now Patient work with Medicare?

Our cash-based prices for medications are typically cheaper than Medicare copays. We do not bill Medicare Part D (standalone drug coverage) or Medicare Advantage (combined health and drug coverage). When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

Does Now Patient work with Commercial Insurance?

Our cash-based prices for medications are typically cheaper than commercial plan copays. We do not bill your commercial plan. When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

What should you do if you use too much ranolazine?


Call your doctor right away or seek immediate medical attention if your symptoms do not improve or they become worse after using ranolazine. You can also call 800-222-1222 to reach the American Association of Poison Control Centers or use its online resource if you think you’ve used too much ranolazine. But if you have severe symptoms, call 911 (or your local emergency number) immediately or go to the nearest emergency room.


If you think it is an emergency, call 999 or find your nearest A&E
If you need help now, but it’s not an emergency go to 111.nhs.uk or call 111. Alternatively you can speak to one of our pharmacists or use the Now Patient app to make an appointment with your GP.

What should I do if I miss my dose?

There are occasions when people forget to take their medication at correct prescribed times. This may not only have an effect on potentially making the medication less effective but it may also inadvertently lead to taking doses too close together, thereby increasing the risks of side effects.

Click here to find out what to do if you forgot to take your medication

What is generic ranolazine?

US brand name of ranolazine and manufacturer

Ranolazine is FDA approved in the US under the brand name Ranexa. It is manufactured by Gilead Sciences.

UK brand name of ranolazine and manufacturer

Ranolazine is available in the UK under the brand name Ranexa. It is also manufactured by Gilead Sciences.

Is ranolazine available in the UK on the NHS?

Yes, ranolazine is available on the NHS in the UK.

Prescription requirement for ranolazine

Ranolazine is a prescription medication and requires a prescription from a healthcare provider.

Active ingredient of ranolazine and mechanism of action

Ranolazine is the active ingredient in Ranexa. It is an antianginal and anti-ischemic medication that works by improving blood flow to the heart and reducing the frequency of angina attacks. The exact mechanism of action is not fully understood, but it is believed to involve the inhibition of certain ion channels in cardiac cells. It is metabolized in the liver by CYP3A4 and CYP2D6 enzymes.

Uses of ranolazine

Ranolazine is primarily used for the treatment of chronic angina, a cardiovascular condition characterized by chest pain or discomfort due to reduced blood flow to the heart. It is typically prescribed in combination with ACE inhibitors, calcium channel blockers (such as amlodipine), anti-platelets, beta-blockers, nitrates (such as nitroglycerin), or lipid-lowering drugs. Ranolazine may be used off-label for the treatment of arrhythmias, such as ventricular tachycardia.

Forms of ranolazine

Ranolazine is available in the form of extended-release tablets. The specific strength and formulation will depend on the individual patient’s needs and the prescribing healthcare provider’s instructions.

Dosage of ranolazine

The dose of ranolazine will vary depending on the individual patient’s condition, response to treatment, and other factors. It is important to follow the dosage instructions provided by your healthcare provider.

Contraindications and warnings for ranolazine

  • Ranolazine should be used with caution in patients with certain conditions, such as liver or renal disease, QT interval prolongation, and certain heart rhythm disorders
  • Ranolazine is not recommended for use in patients with liver cirrhosis
  • It may interact with other medications, so it is important to inform your healthcare provider about all the medications you are taking
  • Ranolazine may cause dizziness or lightheadedness, so caution should be exercised when driving or operating machinery
  • Do not eat grapefruit or drink grapefruit juice while taking this medication
  • It is not known if ranolazine passes into breast milk. Speak to your doctor before breast-feeding

Side effects of ranolazine

In clinical trials common side effects of ranolazine may include dizziness, headache, constipation, nausea, weakness, and reduced potassium levels. It may also cause more serious side effects, such as QT prolongation, irregular heartbeats, chest pain, low blood pressure, liver problems, and allergic reactions. If you experience any concerning or persistent adverse effects, contact your healthcare provider immediately.

Interactions with other drugs

Ranolazine can interact with other medications, including antifungals such as itraconazole and ketoconazole, clarithromycin, ritonavir, nelfinavir, ritonavir, nefazodone, medications for seizures such as carbamazepine, phenobarbital, and phenytoin, rifabutin, rifampin, rifapentin, St. John’s wort, amiodarone, diltiazem, erythromycin, metformin, and verapamil. It is important to inform your healthcare provider about all the prescription drugs, over the counter nonprescription medication, supplements, and vitamins you are taking to avoid potential drug interactions.


  • Ranexa (Ranolazine) Prescribing Information – Gilead Sciences.
  • Ranolazine – MedlinePlus.
Stefano Mirabello Medical Reviewer
Pharmacist / B.Pharm
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