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Qsymia is the brand name for phentermine and topiramate extended-release, a prescription medication used for chronic weight management. It is a combination of two medicines that help reduce appetite and increase feelings of fullness.
Qsymia is used together with a reduced-calorie diet and increased physical activity to help patients lose weight and maintain weight loss.

Qsymia is available as extended-release oral capsules in the following strengths of phentermine and topiramate:
3.75 mg/23 mg

7.5 mg/46 mg

11.25 mg/69 mg

15 mg/92 mg

Qsymia is used for chronic weight management in combination with a reduced-calorie diet and increased physical activity.
It may be prescribed for:
Adults with:
A BMI of 30 or higher (obesity)

A BMI of 27 or higher (overweight) with at least one weight-related condition, such as:

High blood pressure

Type 2 diabetes

High cholesterol

Children 12 years and older:
With obesity, as part of a supervised weight-management program.

It is not known whether Qsymia reduces the risk of heart problems or stroke.

Qsymia works through the combined effects of its two active ingredients.
Phentermine is an appetite suppressant that affects the central nervous system and helps reduce hunger.
Topiramate is a medication that may increase feelings of fullness, reduce appetite, and help control food cravings.
Together, these effects can help patients eat less and lose weight when combined with diet and exercise.

Qsymia is usually taken once daily in the morning, with or without food.
Treatment typically begins with a lower dose that may gradually be increased depending on your response and tolerance.
Do not take Qsymia later in the day because it may cause difficulty sleeping.
Do not stop taking Qsymia suddenly, especially at higher doses, because this may increase the risk of seizures. Your doctor may gradually reduce the dose before stopping the medication.
Always follow your healthcare provider’s instructions regarding how and when to take Qsymia.

Qsymia is generally safe and effective for many patients when used as directed. However, it may not be suitable if you have certain health conditions.
Do not take Qsymia if you have:

Glaucoma
Hyperthyroidism (overactive thyroid)
Used a monoamine oxidase inhibitor (MAOI) within the last 14 days
Known hypersensitivity to phentermine, topiramate, or any of its ingredients
Are pregnant or are planning to become pregnant

Always discuss your medical history with your doctor before using Qsymia.

Common side effects of Qsymia include:
Tingling or numbness in the hands, feet, or face

Dizziness

Changes in taste

Difficulty sleeping (insomnia)

Constipation

Dry mouth

Serious side effects are not common. However, you should seek immediate medical attention if you experience:
Vision problems or eye pain
Mood changes, depression, or suicidal thoughts
Kidney stones or severe stomach pain
Concentration, memory, and speech difficulties
Decreased sweating with increased body temperature
Severe allergic reactions (rash, itching, swelling, difficulty breathing)
Seizures, especially if the medication is stopped suddenly
Severe skin reactions, which may include a rash with blisters and peeling skin, especially around the mouth, nose, eyes, or genitals. These reactions may include Stevens-Johnson Syndrome or Toxic Epidermal Necrolysis

Qsymia may be affected by certain drug classes, and you should let your doctor know if you are taking:
Monoamine oxidase inhibitors (MAOIs)
Other weight-loss medications or stimulants
Central nervous system depressants such as sleep medicines, anxiety medications, or alcohol
Medications that affect carbonic anhydrase enzymes

Do not drink alcohol while taking Qsymia because it may increase certain side effects.
Always consult your healthcare provider before combining Qsymia with other medications.

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Qsymia should not be used during pregnancy. Taking Qsymia during pregnancy may increase the risk of birth defects, including cleft lip and cleft palate. Women who can become pregnant should use effective birth control and have regular pregnancy tests while taking Qsymia.

• Phentermine And Topiramate Extended-Release