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MEDICAL INFORMATION

Phentermine and Topiramate Extended-Release Key Facts

Medically reviewed by Jamie Winn, Pharm.D

Written by Stefano Mirabello, B.Pharm

Created

March 16, 2026 (Current Version)

What dosages is Phentermine And Topiramate Extended-Release available in?

Phentermine And Topiramate Extended-Release is available as extended-release oral capsules in the following strengths of phentermine and topiramate:
3.75 mg/23 mg

7.5 mg/46 mg

11.25 mg/69 mg

15 mg/92 mg

What is Phentermine And Topiramate Extended-Release used for?

Phentermine And Topiramate Extended-Release is used for chronic weight management in combination with a reduced-calorie diet and increased physical activity.
It may be prescribed for:
Adults with:
A BMI of 30 or higher (obesity)

A BMI of 27 or higher (overweight) with at least one weight-related condition, such as:

High blood pressure

Type 2 diabetes

High cholesterol

Children 12 years and older:
With obesity, as part of a supervised weight-management program.

It is not known whether Phentermine And Topiramate Extended-Release reduces the risk of heart problems or stroke.

How does Phentermine And Topiramate Extended-Release work?

Phentermine And Topiramate Extended-Release works through the combined effects of its two active ingredients.
Phentermine is an appetite suppressant that affects the central nervous system and helps reduce hunger.
Topiramate is a medication that may increase feelings of fullness, reduce appetite, and help control food cravings.
Together, these effects can help patients eat less and lose weight when combined with diet and exercise.

How do I take Phentermine And Topiramate Extended-Release?

Phentermine And Topiramate Extended-Release is usually taken once daily in the morning, with or without food.
Treatment typically begins with a lower dose that may gradually be increased depending on your response and tolerance.
Do not take Phentermine And Topiramate Extended-Release later in the day because it may cause difficulty sleeping.
Do not stop taking Phentermine And Topiramate Extended-Release suddenly, especially at higher doses, because this may increase the risk of seizures. Your doctor may gradually reduce the dose before stopping the medication.
Always follow your healthcare provider’s instructions regarding how and when to take Phentermine And Topiramate Extended-Release.

Is it safe for me to take Phentermine And Topiramate Extended-Release?

Phentermine And Topiramate Extended-Release is generally safe and effective for many patients when used as directed. However, it may not be suitable if you have certain health conditions.
Do not take Phentermine And Topiramate Extended-Release if you have:

Glaucoma
Hyperthyroidism (overactive thyroid)
Used a monoamine oxidase inhibitor (MAOI) within the last 14 days
Known hypersensitivity to phentermine, topiramate, or any of its ingredients
Are pregnant or are planning to become pregnant

Always discuss your medical history with your doctor before using Phentermine And Topiramate Extended-Release.

Phentermine And Topiramate Extended-Release Common Side Effects

Common side effects of Phentermine And Topiramate Extended-Release include:
Tingling or numbness in the hands, feet, or face

Dizziness

Changes in taste

Difficulty sleeping (insomnia)

Constipation

Dry mouth

Phentermine And Topiramate Extended-Release Serious Side Effects

Serious side effects are not common. However, you should seek immediate medical attention if you experience:
Vision problems or eye pain
Mood changes, depression, or suicidal thoughts
Kidney stones or severe stomach pain
Concentration, memory, and speech difficulties
Decreased sweating with increased body temperature
Severe allergic reactions (rash, itching, swelling, difficulty breathing)
Seizures, especially if the medication is stopped suddenly
Severe skin reactions, which may include a rash with blisters and peeling skin, especially around the mouth, nose, eyes, or genitals. These reactions may include Stevens-Johnson Syndrome or Toxic Epidermal Necrolysis

Effects of other drugs, drug classes and over-the-counter products on Phentermine And Topiramate Extended-Release

Phentermine And Topiramate Extended-Release may be affected by certain drug classes, and you should let your doctor know if you are taking:
Monoamine oxidase inhibitors (MAOIs)
Other weight-loss medications or stimulants
Central nervous system depressants such as sleep medicines, anxiety medications, or alcohol
Medications that affect carbonic anhydrase enzymes

Do not drink alcohol while taking Phentermine And Topiramate Extended-Release because it may increase certain side effects.
Always consult your healthcare provider before combining Phentermine And Topiramate Extended-Release with other medications.

Who makes Phentermine And Topiramate Extended-Release?

Various FDA-approved generic manufacturers

Is Phentermine And Topiramate Extended-Release safe in pregnancy?

Phentermine And Topiramate Extended-Release should not be used during pregnancy. Taking Phentermine And Topiramate Extended-Release during pregnancy may increase the risk of birth defects, including cleft lip and cleft palate. Women who can become pregnant should use effective birth control and have regular pregnancy tests while taking Phentermine And Topiramate Extended-Release.

What is the brand name for Phentermine And Topiramate Extended-Release?

Qsymia

Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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We are a broad skilled and passionate group of clinicians with experience of operating in regulated health systems in the United Kingdom & United States. Providing excellent care and advice is at the heart of everything we do. You can read more about our medical team by visiting the medical team page or learn more about how we curate content by visiting our editorial process