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Phentermine/Topiramate XR is available as extended-release oral capsules in the following strengths of phentermine and topiramate: 3.75 mg/23 mg 7.5 mg/46 mg 11.25 mg/69 mg 15 mg/92 mg

Phentermine/Topiramate XR is used for chronic weight management in combination with a reduced-calorie diet and increased physical activity. It may be prescribed for: Adults with: A BMI of 30 or higher (obesity) A BMI of 27 or higher (overweight) with at least one weight-related condition, such as: High blood pressure Type 2 diabetes High cholesterol Children 12 years and older: With obesity, as part of a supervised weight-management program. It is not known whether Phentermine/Topiramate XR reduces the risk of heart problems or stroke.

Phentermine/Topiramate XR works through the combined effects of its two active ingredients. Phentermine is an appetite suppressant that affects the central nervous system and helps reduce hunger. Topiramate is a medication that may increase feelings of fullness, reduce appetite, and help control food cravings. Together, these effects can help patients eat less and lose weight when combined with diet and exercise.

Phentermine/Topiramate XR is usually taken once daily in the morning, with or without food. Treatment typically begins with a lower dose that may gradually be increased depending on your response and tolerance. Do not take Phentermine/Topiramate XR later in the day because it may cause difficulty sleeping. Do not stop taking Phentermine/Topiramate XR suddenly, especially at higher doses, because this may increase the risk of seizures. Your doctor may gradually reduce the dose before stopping the medication. Always follow your healthcare provider’s instructions regarding how and when to take Phentermine/Topiramate XR.

Phentermine/Topiramate XR is generally safe and effective for many patients when used as directed. However, it may not be suitable if you have certain health conditions. Do not take Phentermine/Topiramate XR if you have: Glaucoma Hyperthyroidism (overactive thyroid) Used a monoamine oxidase inhibitor (MAOI) within the last 14 days Known hypersensitivity to phentermine, topiramate, or any of its ingredients Are pregnant or are planning to become pregnant Always discuss your medical history with your doctor before using Phentermine/Topiramate XR.

Common side effects of Phentermine/Topiramate XR include: Tingling or numbness in the hands, feet, or face Dizziness Changes in taste Difficulty sleeping (insomnia) Constipation Dry mouth 

Serious side effects are not common. However, you should seek immediate medical attention if you experience:
Vision problems or eye pain
Mood changes, depression, or suicidal thoughts
Kidney stones or severe stomach pain
Concentration, memory, and speech difficulties
Decreased sweating with increased body temperature
Severe allergic reactions (rash, itching, swelling, difficulty breathing)
Seizures, especially if the medication is stopped suddenly
Severe skin reactions, which may include a rash with blisters and peeling skin, especially around the mouth, nose, eyes, or genitals. These reactions may include Stevens-Johnson Syndrome or Toxic Epidermal Necrolysis

Phentermine/Topiramate XR may be affected by certain drug classes, and you should let your doctor know if you are taking: Monoamine oxidase inhibitors (MAOIs) Other weight-loss medications or stimulants Central nervous system depressants such as sleep medicines, anxiety medications, or alcohol Medications that affect carbonic anhydrase enzymes Do not drink alcohol while taking Phentermine/Topiramate XR because it may increase certain side effects. Always consult your healthcare provider before combining Phentermine/Topiramate XR with other medications. 

Various FDA-approved generic manufacturers

Phentermine/Topiramate XR should not be used during pregnancy. Taking Phentermine/Topiramate XR during pregnancy may increase the risk of birth defects, including cleft lip and cleft palate. Women who can become pregnant should use effective birth control and have regular pregnancy tests while taking Phentermine/Topiramate XR.

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