Used for Epilepsy

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Manufactured by various FDA-approved generic manufacturers.

*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.

This content is intended for US audiences only

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primidone Uses, Side Effects, Interactions, Warnings & Dosing

What dosages is primidone available in?

What dosages is primidone available in?

primidone is available as a 50 mg, 125 mg, and 250 mg oral tablet.

What is primidone used for?

What is primidone used for?

primidone is an antiepileptic and is used to treat:

  • Generalized tonic-clonic (grand mal) seizures
  • Complex partial (psychomotor) seizures
  • Partial (focal) seizures
How does primidone work?

How does primidone work?

primidone is an antiepileptic (anti-seizure) medication. It’s not clear exactly how it works to treat seizures, but it’s thought to lower the amount of unusual electrical brain activity to help control seizures. The body metabolizes (breaks down) primidone into different chemicals that also help calm the nerves in your brain; one of those chemicals is phenobarbital, a medication that’s used for seizures and sedation.

How do I take primidone?

How do I take primidone?

primidone is typically started at 50 mg to 125 mg by mouth at bedtime. Your provider will raise your dose slowly until you reach a maintenance (long-term) dose. The typical maintenance dose is 250 mg taken three or four times a day, but some people might need more. The maximum dose is 500 mg taken four times a day.

Is it safe for me to take primidone?

Is it safe for me to take primidone?

primidone is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have porphyria or are hypersensitive to

primidone Common Side Effects

primidone Common Side Effects

Common side effects of primidone:

  • Difficulty with movement or coordination
  • Feeling like the room is spinning (vertigo)
  • Nausea
  • Vomiting
  • Poor appetite
  • Drowsiness
primidone Serious Side Effects

primidone Serious Side Effects

Serious side effects are rare with primidone. Contact your healthcare provider immediately if you experience any of the following.

  • Thoughts of hurting yourself or of suicide
  • Low blood cell counts: getting infections more often, bleeding or bruising more easily, feeling weak or short of breath more than usual
Effects of other drugs, drug classes and over-the-counter products on primidone

Effects of other drugs, drug classes and over-the-counter products on primidone

The following medications may interact with primidone:

  • primidone can speed up the removal of other medications from your body, which may affect how they work. Examples of affected drugs include artemether/lumefantrine, asunaprevir, atazanavir, cobicistat, lurasidone, ranolazine, sofosbuvir, sorafenib, voriconazole, certain calcium channel blockers such as felodipine/nimodipine, among others
  • primidone may decrease the effectiveness of hormonal birth control such as pills, patch, or ring
  • may decrease the effectiveness of hormonal birth control such as pills, patch, or ring
  • Opioid pain or cough relievers (such as codeine, hydrocodone), alcohol, marijuana (cannabis), other drugs for sleep or anxiety (such as alprazolam, lorazepam, zolpidem), muscle relaxants (such as carisoprodol, cyclobenzaprine), or antihistamines (such as cetirizine, diphenhydramine): May increase the risk of serious side effects such as slow/shallow breathing and severe drowsiness/dizziness
Who makes primidone?

Who makes primidone?

Various FDA-approved generic manufacturers

Is primidone safe in pregnancy?

Is primidone safe in pregnancy?

It is not known if primidone will harm your unborn baby. You should talk to your healthcare provider before taking this medication if you are pregnant. There is a pregnancy exposure registry that monitors pregnancy outcomes in women exposed to AEDs, including primidone during pregnancy. Encourage women who are taking primidone during pregnancy to enroll in the North American Antiepileptic Drug (NAAED)
Pregnancy Registry by calling 1-888-233-2334 or visiting AED pregnancy registry 


What to do if you missed your primidone dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

Learn more about reporting side effects
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NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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