PrimidonePrices, Coupons & Savings

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1. Medication
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   US ONLY
2. Primidone

   Generic for Mysoline

   Rx

   50mg

   30 tablets $6.6 USD

   30 tablets $6.6 USD - 0.22 USD/tablet
   Save $7.50

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Do you need a prescription for primidone?

Yes, primidone is only available with a valid physician Rx.

How much is primidone without Insurance in the US?

Our website gives two competitive savings options to US customers who wish to purchase primidone, as either a brand or generic, if available. The first is access to medications through our mail-order online pharmacy. The second is by using the Now Patient Rx Advantage Card, which can be used in over 65,000 pharmacies nationwide, across America. If you are insured, then in most cases, the cash price will be significantly cheaper than the copay.

What will my out-of-pocket cost be for primidone in the US?

There are no out-of-pocket (OOP) costs because we are currently only offering a cash-based option to purchase medications.

Is Now Patient a primidone savings card?

Yes. Save up to 90% on your primidone with the FREE Now Patient Rx Advantage card*.
*Based on the difference between the U&C submitted by the pharmacy and the price the patients pay.

Can you handle Rx transfers for home delivery in the US?

Yes. If you use the mail-order online pharmacy option, then we can handle requests by you to have your prescription transferred to our pharmacy for home delivery. We can even help you manage your refills by giving you timely reminders, so you do not run out of your medication.

Is Now Patient a primidone coupon provider in the US?

No. Now Patient does not provide primidone coupons or FREE primidone samples.

Do you accept commercial, Medicare or Medicaid coverage for primidone in the US?

No. Currently, we only offer cash-based options for purchase, therefore we do not require your insurance benefit details. In the future, our plan is to be able to handle commercial insurance, Medicare and Medicaid including cases where you have multiple health plans that provide benefit coverage (e.g. Medicaid and Commercial). We also anticipate being able to handle more complex scenarios such as using primary insurance combined with a manufacturer copay assistance program.

Does Now Patient work with Medicare?

Our cash-based prices for medications are typically cheaper than Medicare copays. We do not bill Medicare Part D (standalone drug coverage) or Medicare Advantage (combined health and drug coverage). When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

Does Now Patient work with Commercial Insurance?

Our cash-based prices for medications are typically cheaper than commercial plan copays. We do not bill your commercial plan. When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

What should you do if you use too much primidone?

US

Call your doctor right away or seek immediate medical attention if your symptoms do not improve or they become worse after using primidone. You can also call 800-222-1222 to reach the American Association of Poison Control Centers or use its online resource if you think you’ve used too much primidone. But if you have severe symptoms, call 911 (or your local emergency number) immediately or go to the nearest emergency room.

UK

If you think it is an emergency, call 999 or find your nearest A&E
If you need help now, but it’s not an emergency go to 111.nhs.uk or call 111. Alternatively you can speak to one of our pharmacists or use the Now Patient app to make an appointment with your GP.

What should I do if I miss my dose?

There are occasions when people forget to take their medication at correct prescribed times. This may not only have an effect on potentially making the medication less effective but it may also inadvertently lead to taking doses too close together, thereby increasing the risks of side effects.

Click here to find out what to do if you forgot to take your medication

US brand name of primidone and manufacturer

Primidone is available in the US under various brand names, including Mysoline. It is manufactured by multiple pharmaceutical companies.

UK brand name of primidone and manufacturer

Primidone is available in the UK under the brand name Mysoline. It is manufactured by various pharmaceutical companies.

Prescription requirement for primidone

Primidone is a prescription medication, and a healthcare provider’s prescription is required to obtain it.

FDA approval of primidone

Primidone has received FDA approval for the treatment of certain types of seizures, including grand mal seizures, psychomotor seizures, and focal epileptic seizures.

Is primidone available in the UK on NHS?

Primidone is available on the NHS in the UK, and a prescription is required to obtain it. It may be prescribed by healthcare providers for the treatment of seizures.

Active ingredient of primidone and mechanism of action

Primidone is an anticonvulsant barbiturate medication that works by reducing abnormal electrical activity in the brain. Primidone is partly metabolized to phenobarbital, which is responsible for some of its pharmacological effects in epilepsy.  The exact mechanism of action is not fully understood, but it is believed to involve enhancing the activity of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) in the brain.

Uses of primidone

Primidone is primarily used for the treatment of various types of seizures, including generalized tonic-clonic seizures, partial seizures, and other types of epilepsy. It may be used alone or in combination with other antiepileptic medications.

Forms of primidone

Primidone is available in tablet form for oral administration. The tablets are available in different strengths, and the specific strength prescribed will depend on the individual’s condition and treatment plan.

Dosage of primidone

The dosage of primidone will vary depending on the individual’s age, weight, and the type of seizures being treated. It is important to follow the medical advice provided by your caregiver and not exceed the prescribed dose.

Route: oral; Strengths: 50 mg tablet, 250 mg tablet
Adult dosage (ages 18–64 years)
Typical dosage if you haven’t had treatment for seizures before:

• Days 1 to 3: 100–125 mg by mouth at bedtime
• Days 4 to 6: 100–125 mg twice per day
• Days 7 to 9: 100–125 mg three times per day
• Day 10 to maintenance: 250 mg three times per day

Typical maintenance dose:

• 250 mg taken three times per day or 250 mg taken four times per day. Your doctor may increase your dosage to five to six 250-mg tablets per day. Your dosage shouldn’t be more than 500 mg taken four times per day
• Typical dosage if you’re already taking other seizure medications:
  • Follow the dosage schedule above while slowly decreasing your other medications until a satisfactory dosage level is achieved for both drugs, or the other medication is completely stopped

Child dosage (ages 8–17 years)

• Typical dosage if your child hasn’t had treatment for seizures before:
  • Days 1 to 3: 100–125 mg by mouth at bedtime
  • Days 4 to 6: 100–125 mg twice per day
  • Days 7 to 9: 100–125 mg three times per day
  • Day 10 to maintenance: 250 mg three times per day
• Typical maintenance dosage:
  • 250 mg taken three times per day or 250 mg taken four times per day. Your doctor may increase your child’s dosage to five to six 250-mg tablets per day. Your child’s dosage shouldn’t be more than 500 mg taken four times per day
• Typical dosage if your child is already taking other seizure medications:
  • Follow the dosage schedule above while slowly decreasing your child’s other medications until a satisfactory dosage level is achieved for both drugs, or the other medication is completely stopped

Precautions and warnings for primidone

• Primidone should not be abruptly discontinued, as it may lead to the worsening of seizures. It should be gradually tapered off under the supervision of a healthcare provider
• Inform your healthcare provider about any existing medical conditions and medications you are taking, as they may interact with primidone
• Primidone may cause drowsiness or dizziness, so it is important to avoid activities that require mental alertness until you know how the medication affects you
• Avoid alcohol while taking Primidone, as it may increase the sedative effects of the medication
• Like other anticonvulsants, primidone has been associated with hyperhomocysteinemia, folate deficiency and its various symptoms (birth defects, depression, and megaloblastic anemia), reduced calcium absorption, and various bone diseases

Adverse effects

Common side effects may include:

• Dizziness
• Drowsiness
• Lack of coordination
• Nausea
• Vomiting
• Loss of appetite

Serious side effects are less common, but they can occur. These can include:

• Unusual tiredness or weakness
• Mental/mood changes (e.g., agitation, confusion, depression, hallucinations)
• Signs of infection (such as sore throat, fever)
• Double vision or other vision changes
• Uncontrolled eye movements
• Severe skin reactions, rash, itching, hives, swelling, severe dizziness, or trouble breathing (potential signs of an allergic reaction)

Drug interactions

Primidone can interact with a number of other medications and substances. Here are some of the most notable interactions:

• Other Central Nervous System (CNS) Depressants: These include opioids, benzodiazepines, some antihistamines, alcohol, and certain other antiepileptic drugs. Taking primidone with these substances can increase the risk of sedation, respiratory depression, and other serious side effects
• Oral Contraceptives: Primidone can decrease the effectiveness of birth control pills, potentially leading to unintended pregnancy. Alternatives or additional contraceptive methods should be considered
• Warfarin and Other Blood Thinners: Primidone can affect how these drugs work, potentially leading to an increased risk of bleeding or clotting
• Certain Antibiotics: Primidone may decrease the blood levels of doxycycline, an antibiotic, making it less effective
• Certain Antifungal Medications: The antifungal drugs itraconazole and voriconazole may increase the blood levels of primidone, which could lead to increased side effects
• Other Antiepileptic Drugs: These include drugs like phenytoin, carbamazepine, lamotrigine. Interactions between these drugs and primidone can alter the effectiveness of the medications and increase the risk of side effects
• Monoamine Oxidase Inhibitors (MAOIs): These drugs, often used to treat depression, can increase the effects of primidone and lead to severe side effects

This is not a complete list of potential interactions. Always inform your healthcare provider of all the medications you’re taking, including over-the-counter drugs and dietary supplements.

Contradindications

• Allergic reactions: People who have had an allergic reaction to primidone or related drugs, like phenobarbital, should not use it
• Porphyria: This is a group of rare genetic disorders that affect the nervous system or skin. People with porphyria should not take primidone, as it can exacerbate their condition
• Respiratory depression: Primidone can suppress the central nervous system, slowing breathing. This could be dangerous for people who already have conditions like asthma, chronic obstructive pulmonary disease (COPD), or sleep apnea
• Liver or kidney disease: These organs help remove primidone from the body. If they’re not functioning properly, the drug could build up in the body and potentially cause harm
• Pregnancy and breastfeeding: Primidone can harm a developing fetus and is excreted into breast milk, which may harm a nursing infant. It should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus, and nursing mothers may need to choose between discontinuing breastfeeding or discontinuing the drug
• Addiction history: Like other barbiturates, primidone has a potential for abuse and physical dependence. Those with a history of drug or alcohol addiction may be at higher risk

Always consult a healthcare professional before starting any new medication, including primidone. This is not an exhaustive list of contraindications.

Warnings for primidone

Primidone, like all medications, carries potential risks and warnings. Here are some of the important ones:

• Suicidal behavior and ideation: Antiepileptic drugs (AEDs), including primidone, increase the risk of suicidal thoughts or behavior in patients taking these drugs for any indication
• Withdrawal symptoms: Do not stop taking primidone suddenly, as it can cause withdrawal symptoms. These can include anxiety, restlessness, insomnia, and even seizures. Your doctor will likely decrease your dose gradually
• Drowsiness and impaired coordination: Primidone can cause drowsiness, dizziness, and problems with muscle coordination. This can be especially dangerous for people who drive, operate machinery, or do other tasks that require alertness
• Depression and mood/behavior changes: Antiepileptic drugs, including primidone, may cause depression or mood and behavior changes. If you experience these symptoms, contact your doctor immediately
• Pregnancy and breastfeeding: As previously mentioned, primidone can harm a developing fetus and is excreted into breast milk, which may harm a nursing infant
• Respiratory depression: Like other barbiturates, primidone can depress the central nervous system, which can slow your breathing. This risk is higher if you’re also taking other drugs that depress the central nervous system like opioids or benzodiazepines
• Hypersensitivity: Some people may develop hypersensitivity reactions to primidone, including skin rash, which may be a sign of more serious reactions
• Overdose: Overdose may present with CNS depression, respiratory depression, suppressed reflexes, coma, reduced response to pain, hypotension, and reduced urine output

This is not an exhaustive list of warnings. Always consult with your doctor or a pharmacist about potential side effects and warnings associated with any new medication.

Sources:

• Micromedex Solutions. Primidone.
• BNF. Primidone.
• MedlinePlus. Primidone.
• Drugs.com. Primidone.