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Is the cost of your primidone too expensive?

You may qualify for programs where you can pay as little as $0 per fill, subject to income and insurance status.

This content is intended for US audiences only

NowPatient offers cost effective access to primidone for everyone including those who are uninsured, those who have commercial insurance as well as those who are enrolled into state or federal programs like Medicaid, Medicare Part D, full Low Income Subsidy (LIS, “Extra Help”), TRICARE or Veterans (VA) Benefits.

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Table of contents
OverviewWhat can I do if I am commercially insured but cannot afford my primidone?What can I do if I am uninsured and cannot afford my primidone?What can I do if I am insured with Medicare and cannot afford my primidone?Am I eligible for the Rx Advantage Card and how much does primidone cost without insurance?What will my out-of-pocket cost be for primidone when using the Rx Advantage Card?Is it legal for me to pay cash for primidone even though I have insurance?Does the Rx Advantage Card work with Medicare or any other federal or state insurance plans?Does the Rx Advantage Card work with Commercial Insurance?How do I check prices for primidone and how do I use the Rx Advantage Card?Do I need to pay for the Rx Advantage Card?Is there a primidone co-pay program?Is there a primidone Patient Assistance Program (PAP)?What should I do if I take too much primidone?What are the benefits of NowPatient?US brand name of primidone and manufacturerUK brand name of primidone and manufacturerPrescription requirement for primidoneFDA approval of primidoneIs primidone available in the UK on NHS?Active ingredient of primidone and mechanism of actionUses of primidoneForms of primidoneDosage of primidonePrecautions and warnings for primidoneAdverse effectsDrug interactionsContradindicationsWarnings for primidoneSourcesPeople also asked
Navin Khosla NowPatientGreen tick
Medically reviewed by Navin Khosla, BPharm and written by Rajive Patel, BPharm - Updated on 25 Jan 2024
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What can I do if I am commercially insured but cannot afford my primidone?

If you are commercially insured and you cannot afford your copay or co-insurance you can opt for purchasing primidone outside of your plan using the Rx Advantage card, with costs that are usually lower than a typical plan copay. If you elect to use this method, out of pocket costs do not contribute towards your plan deductibles.

If you cannot afford the cash price possibly due to income constraints, then there is the option of applying to state assistance programs like Medicaid. Often, you may be able to receive your primidone without any costs at all. You can check Medicaid eligibility in your state by following this link HealthCare.gov. The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application.

What can I do if I am uninsured and cannot afford my primidone?

If you cannot afford the cash price of primidone using the Rx Advantage card then there is the option of applying to state programs like Medicaid. Often, you may be able to receive your primidone without any costs at all. You can check Medicaid eligibility in your state by following this link HealthCare.gov. The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application.

What can I do if I am insured with Medicare and cannot afford my primidone?

If you are insured with Medicare and have Part D or an Advantage drug plan but cannot afford your copay or co-insurance element (for example if you are in the coverage gap or Donut Hole) then you have a number of options:

Option

Savings Information

RX ADVANTAGE CARD

You can use the Rx Advantage to purchase the medication outside of your plan at prices that may be lower than you copay or co-insurance element. If you elect to use this method, out of pocket costs do not contribute towards your plan deductibles.

LOW INCOME SUBSIDY

If this is still too expensive or unaffordable then you can apply for federal support like Low Income Subsidy (LIS). To be eligible for Low Income Subsidy, you need to be resident in one of the 50 States or the District of Columbia. You can check eligibility online at SSA Medicare D Extra Help. You can also call Social Security at 1-800-772-1213 (TTY 1-800-325-0778).

MEDICAID

Alternatively, you can check Medicaid eligibility in your state by following this link to the HealthCare.gov. The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.

Am I eligible for the Rx Advantage Card and how much does primidone cost without insurance?

Our website gives savings options to customers who wish to purchase primidone, as either a brand or generic, without the constraints of insurance. By using the Rx Advantage Card, users can save up to 90% on the cost of their medication. The card can be used at over 65,000 pharmacies nationwide, across America. Even if you are insured, in most cases the cash price will be significantly cheaper than your existing co-pay. NowPatient is able to negotiate discounts on bulk drug purchases with pharmacy owners meaning you can access lower medication prices at nearby pharmacies using our card that can be conveniently stored in your NowPatient account.

What will my out-of-pocket cost be for primidone when using the Rx Advantage Card?

Your out-of-pocket (OOP) cost will effectively be the discounted cash price you pay for primidone using the Rx Advantage Card. If you are insured, your OOP expense can not be used against your plan deductible, if your plan has a deductible.

Yes. The Rx Advantage card is especially useful for people who have High-deductible health plans (HDHPs). It can be used for insured, uninsured, and underinsured persons.

Does the Rx Advantage Card work with Medicare or any other federal or state insurance plans?

No. We do not bill any federal or state insurance including Medicare Part D (standalone drug coverage) or Medicare Advantage (combined health and drug benefit). When you purchase your medication using the NowPatient Rx Advantage Card, you will be doing so out of pocket. The spend will not count towards your plan deductibles or gaps in the event you have a plan with a deductible. The out-of-pocket primidone cash price you pay can be typically cheaper than your plan copay.

Does the Rx Advantage Card work with Commercial Insurance?

We do not bill your commercial insurance. When you purchase your medication using the Rx Advantage Card, from NowPatient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps in the event you have a plan with a deductible. The out-of-pocket primidone cash price you pay can be typically cheaper than your plan copay.

How do I check prices for primidone and how do I use the Rx Advantage Card?

You can search for the prices at nearby pharmacies using our website. Simply search your medication and enter your ZIP Code and we will show you the price of your drug at nearby pharmacies. If you are happy with the quote, you need to create an account with NowPatient and generate your card. Next, simply go to the pharmacy and fill your primidone Rx. Ask the pharmacy to run the card and check the price, even if they tell you they have another card they use. Your card is stored safely in your NowPatient account.

Do I need to pay for the Rx Advantage Card?

No. The Rx Advantage prescription savings card is FREE to use and store for NowPatient users.

Is there a primidone co-pay program?

Generic medications like primidone do not have co-pay card savings options. A Copay program, if available, would normally be for the brand name version of primidone. You can search the brand name of primidone and check to see if a co-pay program exists. Co-pay cards are programs run by pharmaceutical companies that offer you a direct way to lower your out-of-pocket costs for prescription drugs for eligible patients. The copay cards essentially allow physicians to prescribe medications that are clinically preferred.

Is there a primidone Patient Assistance Program (PAP)?

Generic medications like primidone do not have PAP savings options. A Patient assistance program, if available would normally be for the brand name version of primidone. You can search the brand name of primidone and check to see if a co-PAP exists. PAPs are programs that are run and sponsored by pharmaceutical companies. They offer uninsured, insured, or underinsured individuals access to high-cost brand-name medications, which may otherwise be unaffordable.

What should I do if I take too much primidone?

Call your doctor right away or seek immediate medical attention if your symptoms do not improve or they become worse after using primidone. You can also call 800-222-1222 to reach the American Association of Poison Control Centers or use its online resource if you think you've used too much primidone. But if you have severe symptoms, call 911 (or your local emergency number) immediately or go to the nearest emergency room.

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US brand name of primidone and manufacturer

Primidone is available in the US under various brand names, including Mysoline. It is manufactured by multiple pharmaceutical companies.

UK brand name of primidone and manufacturer

Primidone is available in the UK under the brand name Mysoline. It is manufactured by various pharmaceutical companies.

Prescription requirement for primidone

Primidone is a prescription medication, and a healthcare provider’s prescription is required to obtain it.

FDA approval of primidone

Primidone has received FDA approval for the treatment of certain types of seizures, including grand mal seizures, psychomotor seizures, and focal epileptic seizures.

Is primidone available in the UK on NHS?

Primidone is available on the NHS in the UK, and a prescription is required to obtain it. It may be prescribed by healthcare providers for the treatment of seizures.

Active ingredient of primidone and mechanism of action

Primidone is an anticonvulsant barbiturate medication that works by reducing abnormal electrical activity in the brain. Primidone is partly metabolized to phenobarbital, which is responsible for some of its pharmacological effects in epilepsy.  The exact mechanism of action is not fully understood, but it is believed to involve enhancing the activity of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) in the brain.

Uses of primidone

Primidone is primarily used for the treatment of various types of seizures, including generalized tonic-clonic seizures, partial seizures, and other types of epilepsy. It may be used alone or in combination with other antiepileptic medications.

Forms of primidone

Primidone is available in tablet form for oral administration. The tablets are available in different strengths, and the specific strength prescribed will depend on the individual’s condition and treatment plan.

Dosage of primidone

The dosage of primidone will vary depending on the individual’s age, weight, and the type of seizures being treated. It is important to follow the medical advice provided by your caregiver and not exceed the prescribed dose.

Route: oral; Strengths: 50 mg tablet, 250 mg tablet
Adult dosage (ages 18–64 years)
Typical dosage if you haven’t had treatment for seizures before:

  • Days 1 to 3: 100–125 mg by mouth at bedtime
  • Days 4 to 6: 100–125 mg twice per day
  • Days 7 to 9: 100–125 mg three times per day
  • Day 10 to maintenance: 250 mg three times per day

Typical maintenance dose:

  • 250 mg taken three times per day or 250 mg taken four times per day. Your doctor may increase your dosage to five to six 250-mg tablets per day. Your dosage shouldn’t be more than 500 mg taken four times per day
  • Typical dosage if you’re already taking other seizure medications:
    • Follow the dosage schedule above while slowly decreasing your other medications until a satisfactory dosage level is achieved for both drugs, or the other medication is completely stopped

Child dosage (ages 8–17 years)

  • Typical dosage if your child hasn’t had treatment for seizures before:
    • Days 1 to 3: 100–125 mg by mouth at bedtime
    • Days 4 to 6: 100–125 mg twice per day
    • Days 7 to 9: 100–125 mg three times per day
    • Day 10 to maintenance: 250 mg three times per day
  • Typical maintenance dosage:
    • 250 mg taken three times per day or 250 mg taken four times per day. Your doctor may increase your child’s dosage to five to six 250-mg tablets per day. Your child’s dosage shouldn’t be more than 500 mg taken four times per day
  • Typical dosage if your child is already taking other seizure medications:
    • Follow the dosage schedule above while slowly decreasing your child’s other medications until a satisfactory dosage level is achieved for both drugs, or the other medication is completely stopped

Precautions and warnings for primidone

  • Primidone should not be abruptly discontinued, as it may lead to the worsening of seizures. It should be gradually tapered off under the supervision of a healthcare provider
  • Inform your healthcare provider about any existing medical conditions and medications you are taking, as they may interact with primidone
  • Primidone may cause drowsiness or dizziness, so it is important to avoid activities that require mental alertness until you know how the medication affects you
  • Avoid alcohol while taking Primidone, as it may increase the sedative effects of the medication
  • Like other anticonvulsants, primidone has been associated with hyperhomocysteinemia, folate deficiency and its various symptoms (birth defects, depression, and megaloblastic anemia), reduced calcium absorption, and various bone diseases

Adverse effects

Common side effects may include:

  • Dizziness
  • Drowsiness
  • Lack of coordination
  • Nausea
  • Vomiting
  • Loss of appetite

Serious side effects are less common, but they can occur. These can include:

  • Unusual tiredness or weakness
  • Mental/mood changes (e.g., agitation, confusion, depression, hallucinations)
  • Signs of infection (such as sore throat, fever)
  • Double vision or other vision changes
  • Uncontrolled eye movements
  • Severe skin reactions, rash, itching, hives, swelling, severe dizziness, or trouble breathing (potential signs of an allergic reaction)

Drug interactions

Primidone can interact with a number of other medications and substances. Here are some of the most notable interactions:

  • Other Central Nervous System (CNS) Depressants: These include opioids, benzodiazepines, some antihistamines, alcohol, and certain other antiepileptic drugs. Taking primidone with these substances can increase the risk of sedation, respiratory depression, and other serious side effects
  • Oral Contraceptives: Primidone can decrease the effectiveness of birth control pills, potentially leading to unintended pregnancy. Alternatives or additional contraceptive methods should be considered
  • Warfarin and Other Blood Thinners: Primidone can affect how these drugs work, potentially leading to an increased risk of bleeding or clotting
  • Certain Antibiotics: Primidone may decrease the blood levels of doxycycline, an antibiotic, making it less effective
  • Certain Antifungal Medications: The antifungal drugs itraconazole and voriconazole may increase the blood levels of primidone, which could lead to increased side effects
  • Other Antiepileptic Drugs: These include drugs like phenytoin, carbamazepine, lamotrigine. Interactions between these drugs and primidone can alter the effectiveness of the medications and increase the risk of side effects
  • Monoamine Oxidase Inhibitors (MAOIs): These drugs, often used to treat depression, can increase the effects of primidone and lead to severe side effects

This is not a complete list of potential interactions. Always inform your healthcare provider of all the medications you’re taking, including over-the-counter drugs and dietary supplements.

Contradindications

  • Allergic reactions: People who have had an allergic reaction to primidone or related drugs, like phenobarbital, should not use it
  • Porphyria: This is a group of rare genetic disorders that affect the nervous system or skin. People with porphyria should not take primidone, as it can exacerbate their condition
  • Respiratory depression: Primidone can suppress the central nervous system, slowing breathing. This could be dangerous for people who already have conditions like asthma, chronic obstructive pulmonary disease (COPD), or sleep apnea
  • Liver or kidney disease: These organs help remove primidone from the body. If they’re not functioning properly, the drug could build up in the body and potentially cause harm
  • Pregnancy and breastfeeding: Primidone can harm a developing fetus and is excreted into breast milk, which may harm a nursing infant. It should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus, and nursing mothers may need to choose between discontinuing breastfeeding or discontinuing the drug
  • Addiction history: Like other barbiturates, primidone has a potential for abuse and physical dependence. Those with a history of drug or alcohol addiction may be at higher risk

Always consult a healthcare professional before starting any new medication, including primidone. This is not an exhaustive list of contraindications.

Warnings for primidone

Primidone, like all medications, carries potential risks and warnings. Here are some of the important ones:

  • Suicidal behavior and ideation: Antiepileptic drugs (AEDs), including primidone, increase the risk of suicidal thoughts or behavior in patients taking these drugs for any indication
  • Withdrawal symptoms: Do not stop taking primidone suddenly, as it can cause withdrawal symptoms. These can include anxiety, restlessness, insomnia, and even seizures. Your doctor will likely decrease your dose gradually
  • Drowsiness and impaired coordination: Primidone can cause drowsiness, dizziness, and problems with muscle coordination. This can be especially dangerous for people who drive, operate machinery, or do other tasks that require alertness
  • Depression and mood/behavior changes: Antiepileptic drugs, including primidone, may cause depression or mood and behavior changes. If you experience these symptoms, contact your doctor immediately
  • Pregnancy and breastfeeding: As previously mentioned, primidone can harm a developing fetus and is excreted into breast milk, which may harm a nursing infant
  • Respiratory depression: Like other barbiturates, primidone can depress the central nervous system, which can slow your breathing. This risk is higher if you’re also taking other drugs that depress the central nervous system like opioids or benzodiazepines
  • Hypersensitivity: Some people may develop hypersensitivity reactions to primidone, including skin rash, which may be a sign of more serious reactions
  • Overdose: Overdose may present with CNS depression, respiratory depression, suppressed reflexes, coma, reduced response to pain, hypotension, and reduced urine output

This is not an exhaustive list of warnings. Always consult with your doctor or a pharmacist about potential side effects and warnings associated with any new medication.

Sources

Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information in this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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