Save on Mysoline with Coupons, Discounts & Savings Programs

Mysoline is the brand name for primidone and is available as an oral tablet.

Mysoline is available as a 50 mg, 125 mg, and 250 mg oral tablet.

Mysoline is an antiepileptic and is used to treat:

• Generalized tonic-clonic (grand mal) seizures
• Complex partial (psychomotor) seizures
• Partial (focal) seizures

Mysoline is an antiepileptic (anti-seizure) medication. It’s not clear exactly how it works to treat seizures, but it’s thought to lower the amount of unusual electrical brain activity to help control seizures. The body metabolizes (breaks down) Mysoline into different chemicals that also help calm the nerves in your brain; one of those chemicals is phenobarbital, a medication that’s used for seizures and sedation.

Mysoline is typically started at 50 mg to 125 mg by mouth at bedtime. Your provider will raise your dose slowly until you reach a maintenance (long-term) dose. The typical maintenance dose is 250 mg taken three or four times a day, but some people might need more. The maximum dose is 500 mg taken four times a day.

Mysoline is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have porphyria or are hypersensitive to
phenobarbital.

Common side effects of Mysoline:

• Difficulty with movement or coordination
• Feeling like the room is spinning (vertigo)
• Nausea
• Vomiting
• Poor appetite
• Drowsiness

Serious side effects are rare with Mysoline. Contact your healthcare provider immediately if you experience any of the following.

• Thoughts of hurting yourself or of suicide
• Low blood cell counts: getting infections more often, bleeding or bruising more easily, feeling weak or short of breath more than usual

The following medications may interact with Mysoline:

• Mysoline can speed up the removal of other medications from your body, which may affect how they work. Examples of affected drugs include artemether/lumefantrine, asunaprevir, atazanavir, cobicistat, lurasidone, ranolazine, sofosbuvir, sorafenib, voriconazole, certain calcium channel blockers such as felodipine/nimodipine, among others
• Mysoline may decrease the effectiveness of hormonal birth control such as pills, patch, or ring
• may decrease the effectiveness of hormonal birth control such as pills, patch, or ring
• Opioid pain or cough relievers (such as codeine, hydrocodone), alcohol, marijuana (cannabis), other drugs for sleep or anxiety (such as alprazolam, lorazepam, zolpidem), muscle relaxants (such as carisoprodol, cyclobenzaprine), or antihistamines (such as cetirizine, diphenhydramine): May increase the risk of serious side effects such as slow/shallow breathing and severe drowsiness/dizziness

Bausch Health

It is not known if Mysoline will harm your unborn baby. You should talk to your healthcare provider before taking this medication if you are pregnant. There is a pregnancy exposure registry that monitors pregnancy outcomes in women exposed to AEDs, including Mysoline during pregnancy. Encourage women who are taking Mysoline during pregnancy to enroll in the North American Antiepileptic Drug (NAAED)
Pregnancy Registry by calling 1-888-233-2334 or visiting AED pregnancy registry 

• Primidone